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Results: 1 to 20 of 97

1.

Relaxin-3/RXFP3 networks: an emerging target for the treatment of depression and other neuropsychiatric diseases?

Smith CM, Walker AW, Hosken IT, Chua BE, Zhang C, Haidar M, Gundlach AL.

Front Pharmacol. 2014 Mar 21;5:46. doi: 10.3389/fphar.2014.00046. eCollection 2014. Review.

PMID:
24711793
[PubMed]
Free PMC Article
2.

Central relaxin-3 receptor (RXFP3) activation decreases anxiety- and depressive-like behaviours in the rat.

Ryan PJ, Büchler E, Shabanpoor F, Hossain MA, Wade JD, Lawrence AJ, Gundlach AL.

Behav Brain Res. 2013 May 1;244:142-51. doi: 10.1016/j.bbr.2013.01.034. Epub 2013 Feb 1.

PMID:
23380674
[PubMed - indexed for MEDLINE]
3.

Relaxin-3/RXFP3 Signaling and Neuroendocrine Function - A Perspective on Extrinsic Hypothalamic Control.

Ganella DE, Ma S, Gundlach AL.

Front Endocrinol (Lausanne). 2013 Sep 18;4:128. doi: 10.3389/fendo.2013.00128. Review.

PMID:
24065955
[PubMed]
Free PMC Article
4.

Central injection of relaxin-3 receptor (RXFP3) antagonist peptides reduces motivated food seeking and consumption in C57BL/6J mice.

Smith CM, Chua BE, Zhang C, Walker AW, Haidar M, Hawkes D, Shabanpoor F, Hossain MA, Wade JD, Rosengren KJ, Gundlach AL.

Behav Brain Res. 2014 Jul 15;268:117-26. doi: 10.1016/j.bbr.2014.03.037. Epub 2014 Mar 25.

PMID:
24681162
[PubMed - in process]
5.

Increased feeding and body weight gain in rats after acute and chronic activation of RXFP3 by relaxin-3 and receptor-selective peptides: functional and therapeutic implications.

Ganella DE, Ryan PJ, Bathgate RA, Gundlach AL.

Behav Pharmacol. 2012 Sep;23(5-6):516-25. doi: 10.1097/FBP.0b013e3283576999. Review.

PMID:
22854307
[PubMed - indexed for MEDLINE]
6.

Distribution of relaxin-3 and RXFP3 within arousal, stress, affective, and cognitive circuits of mouse brain.

Smith CM, Shen PJ, Banerjee A, Bonaventure P, Ma S, Bathgate RA, Sutton SW, Gundlach AL.

J Comp Neurol. 2010 Oct 1;518(19):4016-45. doi: 10.1002/cne.22442.

PMID:
20737598
[PubMed - indexed for MEDLINE]
7.

Nucleus incertus--an emerging modulatory role in arousal, stress and memory.

Ryan PJ, Ma S, Olucha-Bordonau FE, Gundlach AL.

Neurosci Biobehav Rev. 2011 May;35(6):1326-41. doi: 10.1016/j.neubiorev.2011.02.004. Epub 2011 Feb 15. Review.

PMID:
21329721
[PubMed - indexed for MEDLINE]
8.

Relaxin-3 systems in the brain--the first 10 years.

Smith CM, Ryan PJ, Hosken IT, Ma S, Gundlach AL.

J Chem Neuroanat. 2011 Dec;42(4):262-75. doi: 10.1016/j.jchemneu.2011.05.013. Epub 2011 Jun 15. Review.

PMID:
21693186
[PubMed - indexed for MEDLINE]
9.

In vitro pharmacological characterization of RXFP3 allosterism: an example of probe dependency.

Alvarez-Jaimes L, Sutton SW, Nepomuceno D, Motley ST, Cik M, Stocking E, Shoblock J, Bonaventure P.

PLoS One. 2012;7(2):e30792. doi: 10.1371/journal.pone.0030792. Epub 2012 Feb 7.

PMID:
22347403
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Elucidation of relaxin-3 binding interactions in the extracellular loops of RXFP3.

Bathgate RA, Oh MH, Ling WJ, Kaas Q, Hossain MA, Gooley PR, Rosengren KJ.

Front Endocrinol (Lausanne). 2013 Feb 22;4:13. doi: 10.3389/fendo.2013.00013. eCollection 2013.

PMID:
23440673
[PubMed]
Free PMC Article
11.

The relaxin family peptide receptor 3 activates extracellular signal-regulated kinase 1/2 through a protein kinase C-dependent mechanism.

van der Westhuizen ET, Werry TD, Sexton PM, Summers RJ.

Mol Pharmacol. 2007 Jun;71(6):1618-29. Epub 2007 Mar 9.

PMID:
17351017
[PubMed - indexed for MEDLINE]
Free Article
12.

Probing the functional domains of relaxin-3 and the creation of a selective antagonist for RXFP3/GPCR135 over relaxin receptor RXFP1/LGR7.

Liu C, Kuei C, Sutton S, Shelton J, Zhu J, Nepomuceno D, Hossain MA, Wade JD, Bathgate RA, Bonaventure P, Lovenberg T.

Ann N Y Acad Sci. 2009 Apr;1160:31-7. doi: 10.1111/j.1749-6632.2008.03790.x.

PMID:
19416155
[PubMed - indexed for MEDLINE]
13.

Relaxin-3/RXFP3 system regulates alcohol-seeking.

Ryan PJ, Kastman HE, Krstew EV, Rosengren KJ, Hossain MA, Churilov L, Wade JD, Gundlach AL, Lawrence AJ.

Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20789-94. doi: 10.1073/pnas.1317807110. Epub 2013 Dec 2.

PMID:
24297931
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Pharmacological activation of RXFP3 is not orexigenic in C57BL/6J mice.

Smith CM, Hosken IT, Downer NL, Chua BE, Hossain MA, Wade JD, Gundlach AL.

Ital J Anat Embryol. 2013;118(1 Suppl):52-5.

PMID:
24640572
[PubMed - indexed for MEDLINE]
15.

Metabolic and neuroendocrine responses to RXFP3 modulation in the central nervous system.

Sutton SW, Shelton J, Smith C, Williams J, Yun S, Motley T, Kuei C, Bonaventure P, Gundlach A, Liu C, Lovenberg T.

Ann N Y Acad Sci. 2009 Apr;1160:242-9. doi: 10.1111/j.1749-6632.2008.03812.x.

PMID:
19416196
[PubMed - indexed for MEDLINE]
16.

H2 relaxin is a biased ligand relative to H3 relaxin at the relaxin family peptide receptor 3 (RXFP3).

van der Westhuizen ET, Christopoulos A, Sexton PM, Wade JD, Summers RJ.

Mol Pharmacol. 2010 May;77(5):759-72. doi: 10.1124/mol.109.061432. Epub 2010 Feb 16.

PMID:
20159943
[PubMed - indexed for MEDLINE]
Free Article
17.

Verification of a relaxin-3 knockout/LacZ reporter mouse as a model of relaxin-3 deficiency.

Smith CM, Shen PJ, Ma S, Sutton SW, Gundlach AL.

Ann N Y Acad Sci. 2009 Apr;1160:259-60. doi: 10.1111/j.1749-6632.2009.03952.x.

PMID:
19416199
[PubMed - indexed for MEDLINE]
18.

Minimization of human relaxin-3 leading to high-affinity analogues with increased selectivity for relaxin-family peptide 3 receptor (RXFP3) over RXFP1.

Shabanpoor F, Akhter Hossain M, Ryan PJ, Belgi A, Layfield S, Kocan M, Zhang S, Samuel CS, Gundlach AL, Bathgate RA, Separovic F, Wade JD.

J Med Chem. 2012 Feb 23;55(4):1671-81. doi: 10.1021/jm201505p. Epub 2012 Feb 8.

PMID:
22257012
[PubMed - indexed for MEDLINE]
19.

Signalling profiles of H3 relaxin, H2 relaxin and R3(BΔ23-27)R/I5 acting at the relaxin family peptide receptor 3 (RXFP3).

Kocan M, Sarwar M, Hossain MA, Wade JD, Summers RJ.

Br J Pharmacol. 2014 Jun;171(11):2827-41. doi: 10.1111/bph.12623.

PMID:
24641548
[PubMed - in process]
20.

[Relaxin-3 and relaxin family peptide receptors--from structure to functions of a newly discovered mammalian brain system].

Kania A, Lewandowski MH, Błasiak A.

Postepy Hig Med Dosw (Online). 2014;68(0):851-64. Polish.

PMID:
24988606
[PubMed - in process]

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