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Results: 1 to 20 of 106

1.

Molecular mechanism for differential recognition of membrane phosphatidylserine by the immune regulatory receptor Tim4.

Tietjen GT, Gong Z, Chen CH, Vargas E, Crooks JE, Cao KD, Heffern CT, Henderson JM, Meron M, Lin B, Roux B, Schlossman ML, Steck TL, Lee KY, Adams EJ.

Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):E1463-72. doi: 10.1073/pnas.1320174111. Epub 2014 Mar 31.

PMID:
24706780
[PubMed - indexed for MEDLINE]
2.

Glioma-derived T cell immunoglobulin- and mucin domain-containing molecule-4 (TIM4) contributes to tumor tolerance.

Xu L, Xiao H, Xu M, Zhou C, Yi L, Liang H.

J Biol Chem. 2011 Oct 21;286(42):36694-9. doi: 10.1074/jbc.M111.292540. Epub 2011 Sep 6.

PMID:
21896488
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Identification of Tim4 as a phosphatidylserine receptor.

Miyanishi M, Tada K, Koike M, Uchiyama Y, Kitamura T, Nagata S.

Nature. 2007 Nov 15;450(7168):435-9. Epub 2007 Oct 24.

PMID:
17960135
[PubMed - indexed for MEDLINE]
4.

TIM1 is an endogenous ligand for LMIR5/CD300b: LMIR5 deficiency ameliorates mouse kidney ischemia/reperfusion injury.

Yamanishi Y, Kitaura J, Izawa K, Kaitani A, Komeno Y, Nakamura M, Yamazaki S, Enomoto Y, Oki T, Akiba H, Abe T, Komori T, Morikawa Y, Kiyonari H, Takai T, Okumura K, Kitamura T.

J Exp Med. 2010 Jul 5;207(7):1501-11. doi: 10.1084/jem.20090581. Epub 2010 Jun 21.

PMID:
20566714
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells.

Kobayashi N, Karisola P, Peña-Cruz V, Dorfman DM, Jinushi M, Umetsu SE, Butte MJ, Nagumo H, Chernova I, Zhu B, Sharpe AH, Ito S, Dranoff G, Kaplan GG, Casasnovas JM, Umetsu DT, Dekruyff RH, Freeman GJ.

Immunity. 2007 Dec;27(6):927-40.

PMID:
18082433
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Disruption of T-cell immunoglobulin and mucin domain molecule (TIM)-1/TIM4 interaction as a therapeutic strategy in a dendritic cell-induced peanut allergy model.

Feng BS, Chen X, He SH, Zheng PY, Foster J, Xing Z, Bienenstock J, Yang PC.

J Allergy Clin Immunol. 2008 Jul;122(1):55-61, 61.e1-7. doi: 10.1016/j.jaci.2008.04.036. Epub 2008 Jun 10.

PMID:
18547633
[PubMed - indexed for MEDLINE]
7.

TIM genes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity.

Freeman GJ, Casasnovas JM, Umetsu DT, DeKruyff RH.

Immunol Rev. 2010 May;235(1):172-89. doi: 10.1111/j.0105-2896.2010.00903.x. Review.

PMID:
20536563
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Regulation of T cell dependent immune responses by TIM family members.

Mariat C, Sánchez-Fueyo A, Alexopoulos SP, Kenny J, Strom TB, Zheng XX.

Philos Trans R Soc Lond B Biol Sci. 2005 Sep 29;360(1461):1681-5. Review.

PMID:
16147532
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

TIM-family proteins promote infection of multiple enveloped viruses through virion-associated phosphatidylserine.

Jemielity S, Wang JJ, Chan YK, Ahmed AA, Li W, Monahan S, Bu X, Farzan M, Freeman GJ, Umetsu DT, Dekruyff RH, Choe H.

PLoS Pathog. 2013 Mar;9(3):e1003232. doi: 10.1371/journal.ppat.1003232. Epub 2013 Mar 28.

PMID:
23555248
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Molecular mechanism of membrane binding of the GRP1 PH domain.

Lai CL, Srivastava A, Pilling C, Chase AR, Falke JJ, Voth GA.

J Mol Biol. 2013 Sep 9;425(17):3073-90. doi: 10.1016/j.jmb.2013.05.026. Epub 2013 Jun 6.

PMID:
23747485
[PubMed - indexed for MEDLINE]
11.

Two-step engulfment of apoptotic cells.

Toda S, Hanayama R, Nagata S.

Mol Cell Biol. 2012 Jan;32(1):118-25. doi: 10.1128/MCB.05993-11. Epub 2011 Oct 28.

PMID:
22037761
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Snake cytotoxins bind to membranes via interactions with phosphatidylserine head groups of lipids.

Konshina AG, Boldyrev IA, Utkin YN, Omel'kov AV, Efremov RG.

PLoS One. 2011 Apr 29;6(4):e19064. doi: 10.1371/journal.pone.0019064.

PMID:
21559494
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Tim4- and MerTK-mediated engulfment of apoptotic cells by mouse resident peritoneal macrophages.

Nishi C, Toda S, Segawa K, Nagata S.

Mol Cell Biol. 2014 Apr;34(8):1512-20. doi: 10.1128/MCB.01394-13. Epub 2014 Feb 10.

PMID:
24515440
[PubMed - indexed for MEDLINE]
14.

Antigen recognition induces phosphatidylserine exposure on the cell surface of human CD8+ T cells.

Fischer K, Voelkl S, Berger J, Andreesen R, Pomorski T, Mackensen A.

Blood. 2006 Dec 15;108(13):4094-101. Epub 2006 Aug 15.

PMID:
16912227
[PubMed - indexed for MEDLINE]
Free Article
15.

Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages.

Fadok VA, Voelker DR, Campbell PA, Cohen JJ, Bratton DL, Henson PM.

J Immunol. 1992 Apr 1;148(7):2207-16.

PMID:
1545126
[PubMed - indexed for MEDLINE]
16.

Differential roles of phosphatidylserine, PtdIns(4,5)P2, and PtdIns(3,4,5)P3 in plasma membrane targeting of C2 domains. Molecular dynamics simulation, membrane binding, and cell translocation studies of the PKCalpha C2 domain.

Manna D, Bhardwaj N, Vora MS, Stahelin RV, Lu H, Cho W.

J Biol Chem. 2008 Sep 19;283(38):26047-58. doi: 10.1074/jbc.M802617200. Epub 2008 Jul 11.

PMID:
18621733
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Epidermal growth factor-like domain repeat of stabilin-2 recognizes phosphatidylserine during cell corpse clearance.

Park SY, Kim SY, Jung MY, Bae DJ, Kim IS.

Mol Cell Biol. 2008 Sep;28(17):5288-98. doi: 10.1128/MCB.01993-07. Epub 2008 Jun 23.

PMID:
18573870
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Specific immunotherapy suppresses Th2 responses via modulating TIM1/TIM4 interaction on dendritic cells.

Zhao CQ, Li TL, He SH, Chen X, An YF, Wu WK, Zhou XH, Li P, Yang PC.

Allergy. 2010 Aug;65(8):986-95. doi: 10.1111/j.1398-9995.2009.02295.x. Epub 2009 Dec 21.

PMID:
20028372
[PubMed - indexed for MEDLINE]
19.

Regulation of phosphatidylserine exposure and phagocytosis of apoptotic T lymphocytes.

Verhoven B, Krahling S, Schlegel RA, Williamson P.

Cell Death Differ. 1999 Mar;6(3):262-70.

PMID:
10200577
[PubMed - indexed for MEDLINE]
Free Article
20.

C1q binds phosphatidylserine and likely acts as a multiligand-bridging molecule in apoptotic cell recognition.

Païdassi H, Tacnet-Delorme P, Garlatti V, Darnault C, Ghebrehiwet B, Gaboriaud C, Arlaud GJ, Frachet P.

J Immunol. 2008 Feb 15;180(4):2329-38.

PMID:
18250442
[PubMed - indexed for MEDLINE]
Free PMC Article

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