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Results: 1 to 20 of 89

1.

Lysine glutarylation is a protein posttranslational modification regulated by SIRT5.

Tan M, Peng C, Anderson KA, Chhoy P, Xie Z, Dai L, Park J, Chen Y, Huang H, Zhang Y, Ro J, Wagner GR, Green MF, Madsen AS, Schmiesing J, Peterson BS, Xu G, Ilkayeva OR, Muehlbauer MJ, Braulke T, Mühlhausen C, Backos DS, Olsen CA, McGuire PJ, Pletcher SD, Lombard DB, Hirschey MD, Zhao Y.

Cell Metab. 2014 Apr 1;19(4):605-17. doi: 10.1016/j.cmet.2014.03.014.

PMID:
24703693
[PubMed - in process]
2.

Urea cycle regulation by mitochondrial sirtuin, SIRT5.

Nakagawa T, Guarente L.

Aging (Albany NY). 2009 Jun 29;1(6):578-81.

PMID:
20157539
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle.

Nakagawa T, Lomb DJ, Haigis MC, Guarente L.

Cell. 2009 May 1;137(3):560-70. doi: 10.1016/j.cell.2009.02.026.

PMID:
19410549
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase.

Du J, Zhou Y, Su X, Yu JJ, Khan S, Jiang H, Kim J, Woo J, Kim JH, Choi BH, He B, Chen W, Zhang S, Cerione RA, Auwerx J, Hao Q, Lin H.

Science. 2011 Nov 11;334(6057):806-9. doi: 10.1126/science.1207861.

PMID:
22076378
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Overexpression of SIRT5 confirms its involvement in deacetylation and activation of carbamoyl phosphate synthetase 1.

Ogura M, Nakamura Y, Tanaka D, Zhuang X, Fujita Y, Obara A, Hamasaki A, Hosokawa M, Inagaki N.

Biochem Biophys Res Commun. 2010 Feb 26;393(1):73-8. doi: 10.1016/j.bbrc.2010.01.081. Epub 2010 Jan 25.

PMID:
20097174
[PubMed - indexed for MEDLINE]
6.

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.

Mol Cell. 2013 Jun 27;50(6):919-30. doi: 10.1016/j.molcel.2013.06.001.

PMID:
23806337
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks.

Rardin MJ, He W, Nishida Y, Newman JC, Carrico C, Danielson SR, Guo A, Gut P, Sahu AK, Li B, Uppala R, Fitch M, Riiff T, Zhu L, Zhou J, Mulhern D, Stevens RD, Ilkayeva OR, Newgard CB, Jacobson MP, Hellerstein M, Goetzman ES, Gibson BW, Verdin E.

Cell Metab. 2013 Dec 3;18(6):920-33. doi: 10.1016/j.cmet.2013.11.013.

PMID:
24315375
[PubMed - indexed for MEDLINE]
8.

Metabolism leaves its mark on the powerhouse: recent progress in post-translational modifications of lysine in mitochondria.

Papanicolaou KN, O'Rourke B, Foster DB.

Front Physiol. 2014 Sep 2;5:301. doi: 10.3389/fphys.2014.00301. eCollection 2014. Review.

PMID:
25228883
[PubMed]
Free PMC Article
9.

Therapeutic modulation of cerebral L-lysine metabolism in a mouse model for glutaric aciduria type I.

Sauer SW, Opp S, Hoffmann GF, Koeller DM, Okun JG, Kölker S.

Brain. 2011 Jan;134(Pt 1):157-70. doi: 10.1093/brain/awq269. Epub 2010 Oct 4.

PMID:
20923787
[PubMed - indexed for MEDLINE]
Free Article
10.

Ethanol metabolism modifies hepatic protein acylation in mice.

Fritz KS, Green MF, Petersen DR, Hirschey MD.

PLoS One. 2013 Sep 20;8(9):e75868. doi: 10.1371/journal.pone.0075868. eCollection 2013.

PMID:
24073283
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Metabolic characterization of a Sirt5 deficient mouse model.

Yu J, Sadhukhan S, Noriega LG, Moullan N, He B, Weiss RS, Lin H, Schoonjans K, Auwerx J.

Sci Rep. 2013 Sep 30;3:2806. doi: 10.1038/srep02806.

PMID:
24076663
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Chemical Probing of the Human Sirtuin 5 Active Site Reveals Its Substrate Acyl Specificity and Peptide-Based Inhibitors.

Roessler C, Nowak T, Pannek M, Gertz M, Nguyen GT, Scharfe M, Born I, Sippl W, Steegborn C, Schutkowski M.

Angew Chem Int Ed Engl. 2014 Aug 11. doi: 10.1002/anie.201402679. [Epub ahead of print]

PMID:
25111069
[PubMed - as supplied by publisher]
13.

System-wide studies of N-lysine acetylation in Rhodopseudomonas palustris reveal substrate specificity of protein acetyltransferases.

Crosby HA, Pelletier DA, Hurst GB, Escalante-Semerena JC.

J Biol Chem. 2012 May 4;287(19):15590-601. doi: 10.1074/jbc.M112.352104. Epub 2012 Mar 13.

PMID:
22416131
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

The antigen for Hep Par 1 antibody is the urea cycle enzyme carbamoyl phosphate synthetase 1.

Butler SL, Dong H, Cardona D, Jia M, Zheng R, Zhu H, Crawford JM, Liu C.

Lab Invest. 2008 Jan;88(1):78-88. Epub 2007 Nov 19.

PMID:
18026163
[PubMed - indexed for MEDLINE]
Free Article
15.

Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.

Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.

Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. doi: 10.1073/pnas.1302961110. Epub 2013 Apr 1.

PMID:
23576753
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

DNA methylation suppresses expression of the urea cycle enzyme carbamoyl phosphate synthetase 1 (CPS1) in human hepatocellular carcinoma.

Liu H, Dong H, Robertson K, Liu C.

Am J Pathol. 2011 Feb;178(2):652-61. doi: 10.1016/j.ajpath.2010.10.023.

PMID:
21281797
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Are sirtuin deacylase enzymes important modulators of mitochondrial energy metabolism?

Osborne B, Cooney GJ, Turner N.

Biochim Biophys Acta. 2014 Apr;1840(4):1295-302. doi: 10.1016/j.bbagen.2013.08.016. Epub 2013 Aug 27. Review.

PMID:
23994496
[PubMed - indexed for MEDLINE]
18.

The first identification of lysine malonylation substrates and its regulatory enzyme.

Peng C, Lu Z, Xie Z, Cheng Z, Chen Y, Tan M, Luo H, Zhang Y, He W, Yang K, Zwaans BM, Tishkoff D, Ho L, Lombard D, He TC, Dai J, Verdin E, Ye Y, Zhao Y.

Mol Cell Proteomics. 2011 Dec;10(12):M111.012658. doi: 10.1074/mcp.M111.012658. Epub 2011 Sep 9.

PMID:
21908771
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

The growing landscape of lysine acetylation links metabolism and cell signalling.

Choudhary C, Weinert BT, Nishida Y, Verdin E, Mann M.

Nat Rev Mol Cell Biol. 2014 Aug;15(8):536-50. doi: 10.1038/nrm3841.

PMID:
25053359
[PubMed - in process]
20.

Sirt5 deacylation activities show differential sensitivities to nicotinamide inhibition.

Fischer F, Gertz M, Suenkel B, Lakshminarasimhan M, Schutkowski M, Steegborn C.

PLoS One. 2012;7(9):e45098. doi: 10.1371/journal.pone.0045098. Epub 2012 Sep 19.

PMID:
23028781
[PubMed - indexed for MEDLINE]
Free PMC Article

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