Format
Items per page
Sort by

Send to:

Choose Destination

Results: 1 to 20 of 102

1.

Design and synthesis of triazolopyrimidine acylsulfonamides as novel anti-mycobacterial leads acting through inhibition of acetohydroxyacid synthase.

Patil V, Kale M, Raichurkar A, Bhaskar B, Prahlad D, Balganesh M, Nandan S, Shahul Hameed P.

Bioorg Med Chem Lett. 2014 May 1;24(9):2222-5. doi: 10.1016/j.bmcl.2014.02.054. Epub 2014 Feb 28.

PMID:
24703230
[PubMed - indexed for MEDLINE]
2.

Syntheses and herbicidal activity of new triazolopyrimidine-2-sulfonamides as acetohydroxyacid synthase inhibitor.

Chen CN, Chen Q, Liu YC, Zhu XL, Niu CW, Xi Z, Yang GF.

Bioorg Med Chem. 2010 Jul 15;18(14):4897-904. doi: 10.1016/j.bmc.2010.06.015. Epub 2010 Jun 11.

PMID:
20598554
[PubMed - indexed for MEDLINE]
3.

Design and synthesis of N-2,6-difluorophenyl-5-methoxyl-1,2,4-triazolo[1,5-a]-pyrimidine-2-sulfonamide as acetohydroxyacid synthase inhibitor.

Chen CN, Lv LL, Ji FQ, Chen Q, Xu H, Niu CW, Xi Z, Yang GF.

Bioorg Med Chem. 2009 Apr 15;17(8):3011-7. doi: 10.1016/j.bmc.2009.03.018. Epub 2009 Mar 14.

PMID:
19342247
[PubMed - indexed for MEDLINE]
4.

Discovery of novel acetohydroxyacid synthase inhibitors as active agents against Mycobacterium tuberculosis by virtual screening and bioassay.

Wang D, Zhu X, Cui C, Dong M, Jiang H, Li Z, Liu Z, Zhu W, Wang JG.

J Chem Inf Model. 2013 Feb 25;53(2):343-53. doi: 10.1021/ci3004545. Epub 2013 Jan 30.

PMID:
23316686
[PubMed - indexed for MEDLINE]
5.

Characterization of acetohydroxyacid synthase from Mycobacterium tuberculosis and the identification of its new inhibitor from the screening of a chemical library.

Choi KJ, Yu YG, Hahn HG, Choi JD, Yoon MY.

FEBS Lett. 2005 Aug 29;579(21):4903-10.

PMID:
16111681
[PubMed - indexed for MEDLINE]
Free Article
6.

Penoxsulam--structure-activity relationships of triazolopyrimidine sulfonamides.

Johnson TC, Martin TP, Mann RK, Pobanz MA.

Bioorg Med Chem. 2009 Jun 15;17(12):4230-40. doi: 10.1016/j.bmc.2009.02.010. Epub 2009 Feb 14.

PMID:
19464188
[PubMed - indexed for MEDLINE]
7.

In vitro and ex vivo activity of new derivatives of acetohydroxyacid synthase inhibitors against Mycobacterium tuberculosis and non-tuberculous mycobacteria.

Sohn H, Lee KS, Ko YK, Ryu JW, Woo JC, Koo DW, Shin SJ, Ahn SJ, Shin AR, Song CH, Jo EK, Park JK, Kim HJ.

Int J Antimicrob Agents. 2008 Jun;31(6):567-71. doi: 10.1016/j.ijantimicag.2008.01.016. Epub 2008 Mar 12.

PMID:
18337064
[PubMed - indexed for MEDLINE]
8.

Identification and evaluation of novel acetolactate synthase inhibitors as antifungal agents.

Richie DL, Thompson KV, Studer C, Prindle VC, Aust T, Riedl R, Estoppey D, Tao J, Sexton JA, Zabawa T, Drumm J, Cotesta S, Eichenberger J, Schuierer S, Hartmann N, Movva NR, Tallarico JA, Ryder NS, Hoepfner D.

Antimicrob Agents Chemother. 2013 May;57(5):2272-80. doi: 10.1128/AAC.01809-12. Epub 2013 Mar 11.

PMID:
23478965
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Acetohydroxyacid synthase: a target for antimicrobial drug discovery.

Pue N, Guddat LW.

Curr Pharm Des. 2014;20(5):740-53.

PMID:
23688082
[PubMed - indexed for MEDLINE]
10.

Role of a highly conserved proline-126 in ThDP binding of Mycobacterium tuberculosis acetohydroxyacid synthase.

Baig IA, Gedi V, Lee SC, Koh SH, Yoon MY.

Enzyme Microb Technol. 2013 Sep 10;53(4):243-9. doi: 10.1016/j.enzmictec.2013.05.006. Epub 2013 May 30.

PMID:
23931689
[PubMed - indexed for MEDLINE]
11.

Acetohydroxyacid synthase from Mycobacterium avium and its inhibition by sulfonylureas and imidazolinones.

Zohar Y, Einav M, Chipman DM, Barak Z.

Biochim Biophys Acta. 2003 Jun 26;1649(1):97-105.

PMID:
12818195
[PubMed - indexed for MEDLINE]
12.

Synthesis and antimycobacterial evaluation of various 6-substituted pyrazolo[3,4-d]pyrimidine derivatives.

Trivedi A, Vaghasiya S, Dholariya B, Dodiya D, Shah V.

J Enzyme Inhib Med Chem. 2010 Dec;25(6):893-9. doi: 10.3109/14756360903540276.

PMID:
21054238
[PubMed - indexed for MEDLINE]
13.

Discovery of low nanomolar and subnanomolar inhibitors of the mycobacterial beta-carbonic anhydrases Rv1284 and Rv3273.

G├╝zel O, Maresca A, Scozzafava A, Salman A, Balaban AT, Supuran CT.

J Med Chem. 2009 Jul 9;52(13):4063-7. doi: 10.1021/jm9004016.

PMID:
19438226
[PubMed - indexed for MEDLINE]
14.

Biochemical characterization and evaluation of potent inhibitors of the Pseudomonas aeruginosa PA01 acetohydroxyacid synthase.

Cho JH, Lee MY, Baig IA, Ha NR, Kim J, Yoon MY.

Biochimie. 2013 Jul;95(7):1411-21. doi: 10.1016/j.biochi.2013.03.007. Epub 2013 Mar 22.

PMID:
23523771
[PubMed - indexed for MEDLINE]
15.

Crystal structure of Mycobacterium tuberculosis 7,8-dihydropteroate synthase in complex with pterin monophosphate: new insight into the enzymatic mechanism and sulfa-drug action.

Baca AM, Sirawaraporn R, Turley S, Sirawaraporn W, Hol WG.

J Mol Biol. 2000 Oct 6;302(5):1193-212. Erratum in: J Mol Biol 2000 Nov 10;303(5):843.

PMID:
11007651
[PubMed - indexed for MEDLINE]
16.

Biochemical and transcription analysis of acetohydroxyacid synthase isoforms in Mycobacterium tuberculosis identifies these enzymes as potential targets for drug development.

Singh V, Chandra D, Srivastava BS, Srivastava R.

Microbiology. 2011 Jan;157(Pt 1):29-37. doi: 10.1099/mic.0.041343-0. Epub 2010 Sep 30.

PMID:
20884690
[PubMed - indexed for MEDLINE]
Free Article
17.

Identification and characterization of inhibitors of Haemophilus influenzae acetohydroxyacid synthase.

Gedi V, Moon JY, Lim WM, Lee MY, Lee SC, Koo BS, Govindwar S, Yoon MY.

Enzyme Microb Technol. 2011 Jun 10;49(1):1-5. doi: 10.1016/j.enzmictec.2011.04.004. Epub 2011 Apr 8.

PMID:
22112263
[PubMed - indexed for MEDLINE]
18.

Development of novel tetrahydrothieno[2,3-c]pyridine-3-carboxamide based Mycobacterium tuberculosis pantothenate synthetase inhibitors: molecular hybridization from known antimycobacterial leads.

Samala G, Devi PB, Nallangi R, Sridevi JP, Saxena S, Yogeeswari P, Sriram D.

Bioorg Med Chem. 2014 Mar 15;22(6):1938-47. doi: 10.1016/j.bmc.2014.01.030. Epub 2014 Feb 6.

PMID:
24565972
[PubMed - indexed for MEDLINE]
19.

Carbonic anhydrase inhibitors. Inhibition of the Rv1284 and Rv3273 beta-carbonic anhydrases from Mycobacterium tuberculosis with diazenylbenzenesulfonamides.

Maresca A, Carta F, Vullo D, Scozzafava A, Supuran CT.

Bioorg Med Chem Lett. 2009 Sep 1;19(17):4929-32. doi: 10.1016/j.bmcl.2009.07.088. Epub 2009 Jul 22.

PMID:
19651511
[PubMed - indexed for MEDLINE]
20.

Elucidating the specificity of binding of sulfonylurea herbicides to acetohydroxyacid synthase.

McCourt JA, Pang SS, Guddat LW, Duggleby RG.

Biochemistry. 2005 Feb 22;44(7):2330-8.

PMID:
15709745
[PubMed - indexed for MEDLINE]
Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

Write to the Help Desk