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NRF2, not always friendly but perhaps misunderstood.

Michalopoulos GK.

Hepatology. 2014 Aug;60(2):461-3. doi: 10.1002/hep.27090. Epub 2014 Jun 18. No abstract available.


Activated Nrf2 impairs liver regeneration in mice by activation of genes involved in cell-cycle control and apoptosis.

Köhler UA, Kurinna S, Schwitter D, Marti A, Schäfer M, Hellerbrand C, Speicher T, Werner S.

Hepatology. 2014 Aug;60(2):670-8. doi: 10.1002/hep.26964. Epub 2014 Jun 18.


Genetic or pharmacologic amplification of nrf2 signaling inhibits acute inflammatory liver injury in mice.

Osburn WO, Yates MS, Dolan PD, Chen S, Liby KT, Sporn MB, Taguchi K, Yamamoto M, Kensler TW.

Toxicol Sci. 2008 Jul;104(1):218-27. doi: 10.1093/toxsci/kfn079. Epub 2008 Apr 15.


Nimesulide-induced electrophile stress activates Nrf2 in human hepatocytes and mice but is not sufficient to induce hepatotoxicity in Nrf2-deficient mice.

Kale VM, Hsiao CJ, Boelsterli UA.

Chem Res Toxicol. 2010 May 17;23(5):967-76. doi: 10.1021/tx100063z.


Blackberry extract attenuates oxidative stress through up-regulation of Nrf2-dependent antioxidant enzymes in carbon tetrachloride-treated rats.

Cho BO, Ryu HW, Jin CH, Choi DS, Kang SY, Kim DS, Byun MW, Jeong IY.

J Agric Food Chem. 2011 Nov 9;59(21):11442-8. doi: 10.1021/jf2021804. Epub 2011 Oct 11.


Nrf2 protects against diquat-induced liver and lung injury.

Wu KC, Zhang Y, Klaassen CD.

Free Radic Res. 2012 Oct;46(10):1220-9. doi: 10.3109/10715762.2012.700709. Epub 2012 Jul 11.


Carlinoside reduces hepatic bilirubin accumulation by stimulating bilirubin-UGT activity through Nrf2 gene expression.

Kundu R, Dasgupta S, Biswas A, Bhattacharya S, Pal BC, Bhattacharya S, Rao PG, Barua NC, Bordoloi M, Bhattacharya S.

Biochem Pharmacol. 2011 Nov 1;82(9):1186-97. doi: 10.1016/j.bcp.2011.07.069. Epub 2011 Jul 27.


Melatonin downregulates nuclear erythroid 2-related factor 2 and nuclear factor-kappaB during prevention of oxidative liver injury in a dimethylnitrosamine model.

Jung KH, Hong SW, Zheng HM, Lee DH, Hong SS.

J Pineal Res. 2009 Sep;47(2):173-83. doi: 10.1111/j.1600-079X.2009.00698.x. Epub 2009 Jul 13.


Transcription factor Nrf2 plays a pivotal role in protection against traumatic brain injury-induced acute intestinal mucosal injury in mice.

Jin W, Wang HD, Hu ZG, Yan W, Chen G, Yin HX.

J Surg Res. 2009 Dec;157(2):251-60. doi: 10.1016/j.jss.2008.08.003. Epub 2008 Sep 4.


Beneficial paracrine effects of cannabinoid receptor 2 on liver injury and regeneration.

Teixeira-Clerc F, Belot MP, Manin S, Deveaux V, Cadoudal T, Chobert MN, Louvet A, Zimmer A, Tordjmann T, Mallat A, Lotersztajn S.

Hepatology. 2010 Sep;52(3):1046-59. doi: 10.1002/hep.23779.


Increased susceptibility of Nrf2-null mice to 1-bromopropane-induced hepatotoxicity.

Liu F, Ichihara S, Valentine WM, Itoh K, Yamamoto M, Sheik Mohideen S, Kitoh J, Ichihara G.

Toxicol Sci. 2010 Jun;115(2):596-606. doi: 10.1093/toxsci/kfq075. Epub 2010 Mar 8.


Nrf2 activates augmenter of liver regeneration (ALR) via antioxidant response element and links oxidative stress to liver regeneration.

Dayoub R, Vogel A, Schuett J, Lupke M, Spieker SM, Kettern N, Hildt E, Melter M, Weiss TS.

Mol Med. 2013 Aug 28;19:237-44. doi: 10.2119/molmed.2013.00027.


Deletion of the selenocysteine tRNA gene in macrophages and liver results in compensatory gene induction of cytoprotective enzymes by Nrf2.

Suzuki T, Kelly VP, Motohashi H, Nakajima O, Takahashi S, Nishimura S, Yamamoto M.

J Biol Chem. 2008 Jan 25;283(4):2021-30. Epub 2007 Nov 26.


Modulation of nuclear factor E2-related factor 2-mediated gene expression in mice liver and small intestine by cancer chemopreventive agent curcumin.

Shen G, Xu C, Hu R, Jain MR, Gopalkrishnan A, Nair S, Huang MT, Chan JY, Kong AN.

Mol Cancer Ther. 2006 Jan;5(1):39-51.


Participation of nuclear factor (erythroid 2-related), factor 2 in ameliorating lithocholic acid-induced cholestatic liver injury in mice.

Tan KP, Wood GA, Yang M, Ito S.

Br J Pharmacol. 2010 Nov;161(5):1111-21. doi: 10.1111/j.1476-5381.2010.00953.x.


Differential effect of covalent protein modification and glutathione depletion on the transcriptional response of Nrf2 and NF-kappaB.

Chia AJ, Goldring CE, Kitteringham NR, Wong SQ, Morgan P, Park BK.

Biochem Pharmacol. 2010 Aug 1;80(3):410-21. doi: 10.1016/j.bcp.2010.04.004. Epub 2010 Apr 21.


Protein tyrosine phosphatase 1B modulates GSK3β/Nrf2 and IGFIR signaling pathways in acetaminophen-induced hepatotoxicity.

Mobasher MA, González-Rodriguez A, Santamaría B, Ramos S, Martín MÁ, Goya L, Rada P, Letzig L, James LP, Cuadrado A, Martín-Pérez J, Simpson KJ, Muntané J, Valverde AM.

Cell Death Dis. 2013 May 9;4:e626. doi: 10.1038/cddis.2013.150.


Nuclear factor-E2-related factor 2 expression in liver is critical for induction of NAD(P)H:quinone oxidoreductase 1 during cholestasis.

Aleksunes LM, Slitt AL, Maher JM, Dieter MZ, Knight TR, Goedken M, Cherrington NJ, Chan JY, Klaassen CD, Manautou JE.

Cell Stress Chaperones. 2006 Winter;11(4):356-63.


Deletion of nuclear factor-E2-related factor-2 leads to rapid onset and progression of nutritional steatohepatitis in mice.

Sugimoto H, Okada K, Shoda J, Warabi E, Ishige K, Ueda T, Taguchi K, Yanagawa T, Nakahara A, Hyodo I, Ishii T, Yamamoto M.

Am J Physiol Gastrointest Liver Physiol. 2010 Feb;298(2):G283-94. doi: 10.1152/ajpgi.00296.2009. Epub 2009 Nov 19.


Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity.

Okawa H, Motohashi H, Kobayashi A, Aburatani H, Kensler TW, Yamamoto M.

Biochem Biophys Res Commun. 2006 Jan 6;339(1):79-88. Epub 2005 Nov 8.

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