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GCK gene-body hypomethylation is associated with the risk of coronary heart disease.

Xu L, Zheng D, Wang L, Jiang D, Liu H, Xu L, Liao Q, Zhang L, Liu P, Shi X, Wang Z, Sun L, Zhou Q, Li N, Huang Y, Le Y, Ye M, Shao G, Duan S.

Biomed Res Int. 2014;2014:151723. doi: 10.1155/2014/151723. Epub 2014 Feb 17.


Elevated CpG island methylation of GCK gene predicts the risk of type 2 diabetes in Chinese males.

Tang L, Ye H, Hong Q, Wang L, Wang Q, Wang H, Xu L, Bu S, Zhang L, Cheng J, Liu P, Le Y, Ye M, Mai Y, Duan S.

Gene. 2014 Sep 1;547(2):329-33. doi: 10.1016/j.gene.2014.06.062. Epub 2014 Jun 30.


Elevated PLA2G7 gene promoter methylation as a gender-specific marker of aging increases the risk of coronary heart disease in females.

Jiang D, Zheng D, Wang L, Huang Y, Liu H, Xu L, Liao Q, Liu P, Shi X, Wang Z, Sun L, Zhou Q, Li N, Xu L, Le Y, Ye M, Shao G, Duan S.

PLoS One. 2013;8(3):e59752. doi: 10.1371/journal.pone.0059752. Epub 2013 Mar 28.


LINE-1 hypomethylation is associated with the risk of coronary heart disease in Chinese population.

Wei L, Liu S, Su Z, Cheng R, Bai X, Li X.

Arq Bras Cardiol. 2014 May;102(5):481-8. Epub 2014 May 9. English, Portuguese.


Aberrant methylation of the GCK gene body is associated with the risk of essential hypertension.

Fan R, Wang WJ, Zhong QL, Duan SW, Xu XT, Hao LM, Zhao J, Zhang LN.

Mol Med Rep. 2015 Aug;12(2):2390-4. doi: 10.3892/mmr.2015.3631. Epub 2015 Apr 16.


Hypermethylation of hepatic Gck promoter in ageing rats contributes to diabetogenic potential.

Jiang MH, Fei J, Lan MS, Lu ZP, Liu M, Fan WW, Gao X, Lu DR.

Diabetologia. 2008 Aug;51(8):1525-33. doi: 10.1007/s00125-008-1034-8. Epub 2008 May 22.


F0 maternal BPA exposure induced glucose intolerance of F2 generation through DNA methylation change in Gck.

Li G, Chang H, Xia W, Mao Z, Li Y, Xu S.

Toxicol Lett. 2014 Aug 4;228(3):192-9. doi: 10.1016/j.toxlet.2014.04.012. Epub 2014 May 1.


Impact of Type 2 diabetes on Glucokinase diabetes (GCK-MODY) phenotype in a Roma (Gypsy) family - case report.

Stanik J, Kusekova M, Huckova M, Valentinova L, Masindova I, Stanikova D, Ferenczova J, Gasperikova D, Klimes I.

Endocr Regul. 2012 Apr;46(2):99-105.


Common genetic variation in the glucokinase gene (GCK) is associated with type 2 diabetes and rates of carbohydrate oxidation and energy expenditure.

Muller YL, Piaggi P, Hoffman D, Huang K, Gene B, Kobes S, Thearle MS, Knowler WC, Hanson RL, Baier LJ, Bogardus C.

Diabetologia. 2014 Jul;57(7):1382-90. doi: 10.1007/s00125-014-3234-8. Epub 2014 Apr 13.


Investigation of the role of epigenetic modification of the rat glucokinase gene in fetal programming.

Bogdarina I, Murphy HC, Burns SP, Clark AJ.

Life Sci. 2004 Jan 30;74(11):1407-15.


Genetic polymorphism of glucokinase on the risk of type 2 diabetes and impaired glucose regulation: evidence based on 298,468 subjects.

Fu D, Cong X, Ma Y, Cai H, Cai M, Li D, Lv M, Yuan X, Huang Y, Lv Z.

PLoS One. 2013;8(2):e55727. doi: 10.1371/journal.pone.0055727. Epub 2013 Feb 18.


Use of HbA1c in the identification of patients with hyperglycaemia caused by a glucokinase mutation: observational case control studies.

Steele AM, Wensley KJ, Ellard S, Murphy R, Shepherd M, Colclough K, Hattersley AT, Shields BM.

PLoS One. 2013 Jun 14;8(6):e65326. doi: 10.1371/journal.pone.0065326. Print 2013.


No association between IRS‑1 promoter methylation and type 2 diabetes.

Ma J, Cheng J, Wang L, Wang H, Xu L, Liu P, Bu S, Zhang L, Le Y, Ye M, Wang Q, Shi Y, Duan S.

Mol Med Rep. 2013 Sep;8(3):949-53. doi: 10.3892/mmr.2013.1569. Epub 2013 Jul 3.


Interaction effect of genetic polymorphisms in glucokinase (GCK) and glucokinase regulatory protein (GCKR) on metabolic traits in healthy Chinese adults and adolescents.

Tam CH, Ma RC, So WY, Wang Y, Lam VK, Germer S, Martin M, Chan JC, Ng MC.

Diabetes. 2009 Mar;58(3):765-9. doi: 10.2337/db08-1277. Epub 2008 Dec 10.


A preliminary study of the relationship between promoter methylation of the ABCG1, GALNT2 and HMGCR genes and coronary heart disease.

Peng P, Wang L, Yang X, Huang X, Ba Y, Chen X, Guo J, Lian J, Zhou J.

PLoS One. 2014 Aug 1;9(8):e102265. doi: 10.1371/journal.pone.0102265. eCollection 2014.


Association of P2Y12 gene promoter DNA methylation with the risk of clopidogrel resistance in coronary artery disease patients.

Su J, Li X, Yu Q, Liu Y, Wang Y, Song H, Cui H, Du W, Fei X, Liu J, Lin S, Wang J, Zheng W, Zhong J, Zhang L, Tong M, Xu J, Chen X.

Biomed Res Int. 2014;2014:450814. doi: 10.1155/2014/450814. Epub 2014 Mar 18.


Male-specific association between dopamine receptor D4 gene methylation and schizophrenia.

Cheng J, Wang Y, Zhou K, Wang L, Li J, Zhuang Q, Xu X, Xu L, Zhang K, Dai D, Zheng R, Li G, Zhang A, Gao S, Duan S.

PLoS One. 2014 Feb 19;9(2):e89128. doi: 10.1371/journal.pone.0089128. eCollection 2014.


CpG methylation changes within the IL2RA promoter in type 1 diabetes of childhood onset.

Belot MP, Fradin D, Mai N, Le Fur S, Zélénika D, Kerr-Conte J, Pattou F, Lucas B, Bougnères P.

PLoS One. 2013 Jul 12;8(7):e68093. doi: 10.1371/journal.pone.0068093. Print 2013.


Association of AGTR1 Promoter Methylation Levels with Essential Hypertension Risk: A Matched Case-Control Study.

Fan R, Mao S, Zhong F, Gong M, Yin F, Hao L, Zhang L.

Cytogenet Genome Res. 2015;147(2-3):95-102. doi: 10.1159/000442366. Epub 2015 Dec 12.


Less but better: cardioprotective lipid profile of patients with GCK-MODY despite lower HDL cholesterol level.

Fendler W, Rizzo M, Borowiec M, Malachowska B, Antosik K, Szadkowska A, Banach M, Urbanska-Kosinska M, Szopa M, Malecki M, Mlynarski W.

Acta Diabetol. 2014 Aug;51(4):625-32. doi: 10.1007/s00592-014-0567-1. Epub 2014 Feb 19.

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