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Results: 1 to 20 of 101

1.

Spiramine derivatives induce apoptosis of Bax(-/-)/Bak(-/-) cell and cancer cells.

Yan C, Huang L, Liu HC, Chen DZ, Liu HY, Li XH, Zhang Y, Geng MY, Chen Q, Hao XJ.

Bioorg Med Chem Lett. 2014 Apr 15;24(8):1884-8. doi: 10.1016/j.bmcl.2014.03.019. Epub 2014 Mar 18.

PMID:
24684844
[PubMed - indexed for MEDLINE]
2.

The BH3 alpha-helical mimic BH3-M6 disrupts Bcl-X(L), Bcl-2, and MCL-1 protein-protein interactions with Bax, Bak, Bad, or Bim and induces apoptosis in a Bax- and Bim-dependent manner.

Kazi A, Sun J, Doi K, Sung SS, Takahashi Y, Yin H, Rodriguez JM, Becerril J, Berndt N, Hamilton AD, Wang HG, Sebti SM.

J Biol Chem. 2011 Mar 18;286(11):9382-92. doi: 10.1074/jbc.M110.203638. Epub 2010 Dec 9.

PMID:
21148306
[PubMed - indexed for MEDLINE]
Free PMC Article
3.
4.

Bak compensated for Bax in p53-null cells to release cytochrome c for the initiation of mitochondrial signaling during Withanolide D-induced apoptosis.

Mondal S, Bhattacharya K, Mallick A, Sangwan R, Mandal C.

PLoS One. 2012;7(3):e34277. doi: 10.1371/journal.pone.0034277. Epub 2012 Mar 29.

PMID:
22479585
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Dioscorealide B from the traditional Thai medicine Hua-Khao-Yen induces apoptosis in MCF-7 human breast cancer cells via modulation of Bax, Bak and Bcl-2 protein expression.

Saekoo J, Graidist P, Leeanansaksiri W, Dechsukum C, Itharat A.

Nat Prod Commun. 2010 Dec;5(12):1921-6.

PMID:
21299121
[PubMed - indexed for MEDLINE]
6.

Paclitaxel-induced apoptosis is BAK-dependent, but BAX and BIM-independent in breast tumor.

Miller AV, Hicks MA, Nakajima W, Richardson AC, Windle JJ, Harada H.

PLoS One. 2013;8(4):e60685. doi: 10.1371/journal.pone.0060685. Epub 2013 Apr 5.

PMID:
23577147
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Approach to the biosynthesis of atisine-type diterpenoid alkaloids.

Zhao PJ, Gao S, Fan LM, Nie JL, He HP, Zeng Y, Shen YM, Hao XJ.

J Nat Prod. 2009 Apr;72(4):645-9. doi: 10.1021/np800657j.

PMID:
19275222
[PubMed - indexed for MEDLINE]
8.
9.

Acquired resistance to rituximab is associated with chemotherapy resistance resulting from decreased Bax and Bak expression.

Olejniczak SH, Hernandez-Ilizaliturri FJ, Clements JL, Czuczman MS.

Clin Cancer Res. 2008 Mar 1;14(5):1550-60. doi: 10.1158/1078-0432.CCR-07-1255.

PMID:
18316580
[PubMed - indexed for MEDLINE]
Free Article
10.

Involvement of proapoptotic molecules Bax and Bak in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced mitochondrial disruption and apoptosis: differential regulation of cytochrome c and Smac/DIABLO release.

Kandasamy K, Srinivasula SM, Alnemri ES, Thompson CB, Korsmeyer SJ, Bryant JL, Srivastava RK.

Cancer Res. 2003 Apr 1;63(7):1712-21.

PMID:
12670926
[PubMed - indexed for MEDLINE]
Free Article
11.

A high-throughput image-based screen for the identification of Bax/Bak-independent caspase activators against drug-resistant cancer cells.

Seervi M, Sobhan PK, Mathew KA, Joseph J, Pillai PR, Santhoshkumar TR.

Apoptosis. 2014 Jan;19(1):269-84. doi: 10.1007/s10495-013-0921-8.

PMID:
24220853
[PubMed - indexed for MEDLINE]
12.

Endogenous Bak inhibitors Mcl-1 and Bcl-xL: differential impact on TRAIL resistance in Bax-deficient carcinoma.

Gillissen B, Wendt J, Richter A, Richter A, Müer A, Overkamp T, Gebhardt N, Preissner R, Belka C, Dörken B, Daniel PT.

J Cell Biol. 2010 Mar 22;188(6):851-62. doi: 10.1083/jcb.200912070.

PMID:
20308427
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Zerumbone causes Bax- and Bak-mediated apoptosis in human breast cancer cells and inhibits orthotopic xenograft growth in vivo.

Sehrawat A, Arlotti JA, Murakami A, Singh SV.

Breast Cancer Res Treat. 2012 Nov;136(2):429-41. doi: 10.1007/s10549-012-2280-5. Epub 2012 Oct 6.

PMID:
23053663
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Antiplatelet aggregation activity of diterpene alkaloids from Spiraea japonica.

Li L, Shen YM, Yang XS, Zuo GY, Shen ZQ, Chen ZH, Hao XJ.

Eur J Pharmacol. 2002 Aug 2;449(1-2):23-8.

PMID:
12163102
[PubMed - indexed for MEDLINE]
15.

BH3-mimetics- and cisplatin-induced cell death proceeds through different pathways depending on the availability of death-related cellular components.

Andreu-Fernández V, Genovés A, Messeguer A, Orzáez M, Sancho M, Pérez-Payá E.

PLoS One. 2013;8(2):e56881. doi: 10.1371/journal.pone.0056881. Epub 2013 Feb 21.

PMID:
23437261
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Bcl-xL is overexpressed in hormone-resistant prostate cancer and promotes survival of LNCaP cells via interaction with proapoptotic Bak.

Castilla C, Congregado B, Chinchón D, Torrubia FJ, Japón MA, Sáez C.

Endocrinology. 2006 Oct;147(10):4960-7. Epub 2006 Jun 22.

PMID:
16794010
[PubMed - indexed for MEDLINE]
17.

Regulation of stress-induced nuclear protein redistribution: a new function of Bax and Bak uncoupled from Bcl-x(L).

Lindenboim L, Blacher E, Borner C, Stein R.

Cell Death Differ. 2010 Feb;17(2):346-59. doi: 10.1038/cdd.2009.145. Epub 2009 Oct 9.

PMID:
19816507
[PubMed - indexed for MEDLINE]
Free Article
18.

Antiplatelet and antithrombotic effects of the diterpene spiramine Q from Spiraea japonica var. incisa.

Shen Z, Chen Z, Li L, Lei W, Hao X.

Planta Med. 2000 Apr;66(3):287-9.

PMID:
10821062
[PubMed - indexed for MEDLINE]
19.

Neuroprotective effects in gerbils of spiramine T from Spiraea japonica var. acuta.

Li L, Nie J, Shen Z, Wu W, Chen Z, Hao X.

Planta Med. 2001 Mar;67(2):142-5.

PMID:
11301860
[PubMed - indexed for MEDLINE]
20.

Pseudomonas exotoxin A-mediated apoptosis is Bak dependent and preceded by the degradation of Mcl-1.

Du X, Youle RJ, FitzGerald DJ, Pastan I.

Mol Cell Biol. 2010 Jul;30(14):3444-52. doi: 10.1128/MCB.00813-09. Epub 2010 May 10.

PMID:
20457813
[PubMed - indexed for MEDLINE]
Free PMC Article

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