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Results: 1 to 20 of 101

1.

Mannosylated N-aryl substituted 3-hydroxypyridine-4-ones: synthesis, hemagglutination inhibitory properties, and molecular modeling.

Car Z, Hrenar T, Petrović Peroković V, Ribić R, Seničar M, Tomić S.

Chem Biol Drug Des. 2014 Oct;84(4):393-401. doi: 10.1111/cbdd.12329. Epub 2014 Jun 3.

PMID:
24674669
[PubMed - in process]
2.

Development of an aggregation assay to screen FimH antagonists.

Abgottspon D, Rölli G, Hosch L, Steinhuber A, Jiang X, Schwardt O, Cutting B, Smiesko M, Jenal U, Ernst B, Trampuz A.

J Microbiol Methods. 2010 Sep;82(3):249-55. doi: 10.1016/j.mimet.2010.06.015. Epub 2010 Jul 8.

PMID:
20620174
[PubMed - indexed for MEDLINE]
3.

The tyrosine gate as a potential entropic lever in the receptor-binding site of the bacterial adhesin FimH.

Wellens A, Lahmann M, Touaibia M, Vaucher J, Oscarson S, Roy R, Remaut H, Bouckaert J.

Biochemistry. 2012 Jun 19;51(24):4790-9. doi: 10.1021/bi300251r. Epub 2012 Jun 7.

PMID:
22657089
[PubMed - indexed for MEDLINE]
4.

Intervening with urinary tract infections using anti-adhesives based on the crystal structure of the FimH-oligomannose-3 complex.

Wellens A, Garofalo C, Nguyen H, Van Gerven N, Slättegård R, Hernalsteens JP, Wyns L, Oscarson S, De Greve H, Hultgren S, Bouckaert J.

PLoS One. 2008 Apr 30;3(4):e2040. doi: 10.1371/journal.pone.0002040. Erratum in: PLoS ONE. 2008;3(6). doi: 10.1371/annotation/ea59d179-0a71-4836-86f0-8d375f5df089.

PMID:
18446213
[PubMed - indexed for MEDLINE]
Free PMC Article
5.
6.

Inhibition of adhesion of type 1 fimbriated Escherichia coli to highly mannosylated ligands.

Nagahori N, Lee RT, Nishimura S, Pagé D, Roy R, Lee YC.

Chembiochem. 2002 Sep 2;3(9):836-44.

PMID:
12210984
[PubMed - indexed for MEDLINE]
7.

Optimizing lectin-carbohydrate interactions: improved binding of divalent alpha-mannosylated ligands towards Concanavalin A.

Pagé D, Roy R.

Glycoconj J. 1997 Apr;14(3):345-56.

PMID:
9147058
[PubMed - indexed for MEDLINE]
8.

Diazo transfer and click chemistry in the solid phase syntheses of lysine-based glycodendrimers as antagonists against Escherichia coli FimH.

Papadopoulos A, Shiao TC, Roy R.

Mol Pharm. 2012 Mar 5;9(3):394-403. doi: 10.1021/mp200490b. Epub 2012 Jan 20.

PMID:
22201286
[PubMed - indexed for MEDLINE]
9.

Receptor binding studies disclose a novel class of high-affinity inhibitors of the Escherichia coli FimH adhesin.

Bouckaert J, Berglund J, Schembri M, De Genst E, Cools L, Wuhrer M, Hung CS, Pinkner J, Slättegård R, Zavialov A, Choudhury D, Langermann S, Hultgren SJ, Wyns L, Klemm P, Oscarson S, Knight SD, De Greve H.

Mol Microbiol. 2005 Jan;55(2):441-55.

PMID:
15659162
[PubMed - indexed for MEDLINE]
10.

Structure-based drug design and optimization of mannoside bacterial FimH antagonists.

Han Z, Pinkner JS, Ford B, Obermann R, Nolan W, Wildman SA, Hobbs D, Ellenberger T, Cusumano CK, Hultgren SJ, Janetka JW.

J Med Chem. 2010 Jun 24;53(12):4779-92. doi: 10.1021/jm100438s.

PMID:
20507142
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Design, synthesis and biological evaluation of mannosyl triazoles as FimH antagonists.

Schwardt O, Rabbani S, Hartmann M, Abgottspon D, Wittwer M, Kleeb S, Zalewski A, Smieško M, Cutting B, Ernst B.

Bioorg Med Chem. 2011 Nov 1;19(21):6454-73. doi: 10.1016/j.bmc.2011.08.057. Epub 2011 Aug 31.

PMID:
21962988
[PubMed - indexed for MEDLINE]
12.

The affinity of the FimH fimbrial adhesin is receptor-driven and quasi-independent of Escherichia coli pathotypes.

Bouckaert J, Mackenzie J, de Paz JL, Chipwaza B, Choudhury D, Zavialov A, Mannerstedt K, Anderson J, Piérard D, Wyns L, Seeberger PH, Oscarson S, De Greve H, Knight SD.

Mol Microbiol. 2006 Sep;61(6):1556-68. Epub 2006 Aug 23.

PMID:
16930149
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Type 1 fimbrial shafts of Escherichia coli and Klebsiella pneumoniae influence sugar-binding specificities of their FimH adhesins.

Madison B, Ofek I, Clegg S, Abraham SN.

Infect Immun. 1994 Mar;62(3):843-8.

PMID:
7906676
[PubMed - indexed for MEDLINE]
Free PMC Article
14.
15.

Bi- and trivalent glycopeptide mannopyranosides as inhibitors of type 1 fimbriae-mediated bacterial adhesion: variation of valency, aglycon and scaffolding.

Schierholt A, Hartmann M, Lindhorst TK.

Carbohydr Res. 2011 Sep 6;346(12):1519-26. doi: 10.1016/j.carres.2011.04.023. Epub 2011 Apr 24.

PMID:
21645881
[PubMed - indexed for MEDLINE]
16.

Target Selectivity of FimH Antagonists.

Scharenberg M, Schwardt O, Rabbani S, Ernst B.

J Med Chem. 2012 Nov 26;55(22):9810-6. doi: 10.1021/jm3010338. Epub 2012 Nov 1.

PMID:
23088608
[PubMed - indexed for MEDLINE]
17.

Carbohydrate specificity of the surface lectins of Escherichia coli, Klebsiella pneumoniae, and Salmonella typhimurium.

Firon N, Ofek I, Sharon N.

Carbohydr Res. 1983 Aug 16;120:235-49.

PMID:
6138149
[PubMed - indexed for MEDLINE]
18.

FimH antagonists: structure-activity and structure-property relationships for biphenyl α-D-mannopyranosides.

Pang L, Kleeb S, Lemme K, Rabbani S, Scharenberg M, Zalewski A, Schädler F, Schwardt O, Ernst B.

ChemMedChem. 2012 Aug;7(8):1404-22. doi: 10.1002/cmdc.201200125. Epub 2012 May 29.

PMID:
22644941
[PubMed - indexed for MEDLINE]
19.

Synthetic multimeric heptyl mannosides as potent antiadhesives of uropathogenic Escherichia coli.

Gouin SG, Wellens A, Bouckaert J, Kovensky J.

ChemMedChem. 2009 May;4(5):749-55. doi: 10.1002/cmdc.200900034.

PMID:
19343765
[PubMed - indexed for MEDLINE]
20.

Lead optimization studies on FimH antagonists: discovery of potent and orally bioavailable ortho-substituted biphenyl mannosides.

Han Z, Pinkner JS, Ford B, Chorell E, Crowley JM, Cusumano CK, Campbell S, Henderson JP, Hultgren SJ, Janetka JW.

J Med Chem. 2012 Apr 26;55(8):3945-59. doi: 10.1021/jm300165m. Epub 2012 Apr 13.

PMID:
22449031
[PubMed - indexed for MEDLINE]
Free PMC Article

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