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Items: 1 to 20 of 100

1.

Staying awake--a genetic region that hinders α2 adrenergic receptor agonist-induced sleep.

Gelegen C, Gent TC, Ferretti V, Zhang Z, Yustos R, Lan F, Yang Q, Overington DW, Vyssotski AL, van Lith HA, Wisden W, Franks NP.

Eur J Neurosci. 2014 Jul;40(1):2311-9. doi: 10.1111/ejn.12570. Epub 2014 Mar 27.

2.

Neuronal ensembles sufficient for recovery sleep and the sedative actions of α2 adrenergic agonists.

Zhang Z, Ferretti V, Güntan İ, Moro A, Steinberg EA, Ye Z, Zecharia AY, Yu X, Vyssotski AL, Brickley SG, Yustos R, Pillidge ZE, Harding EC, Wisden W, Franks NP.

Nat Neurosci. 2015 Apr;18(4):553-61. doi: 10.1038/nn.3957. Epub 2015 Feb 23.

3.

The alpha2-adrenoceptor agonist dexmedetomidine converges on an endogenous sleep-promoting pathway to exert its sedative effects.

Nelson LE, Lu J, Guo T, Saper CB, Franks NP, Maze M.

Anesthesiology. 2003 Feb;98(2):428-36.

PMID:
12552203
5.

Sedative but not analgesic alpha2 agonist tolerance is blocked by NMDA receptor and nitric oxide synthase inhibitors.

Davies MF, Reid K, Guo TZ, Agashe GS, Amin YK, Maze M.

Anesthesiology. 2001 Jul;95(1):184-91.

PMID:
11465557
6.
7.

Desensitization to the behavioral effects of alpha 2-adrenergic agonists in rats.

Hayashi Y, Guo TZ, Maze M.

Anesthesiology. 1995 Apr;82(4):954-62.

PMID:
7717568
8.

Pharmacologic characterization of the receptor mediating the hypnotic action of dexmedetomidine.

Doze V, Chen BX, Li Z, Maze M.

Acta Vet Scand Suppl. 1989;85:61-4.

PMID:
2571279
9.
10.

Alpha-2 adrenergic modulation of sleep: time-of-day-dependent pharmacodynamic profiles of dexmedetomidine and clonidine in the rat.

Seidel WF, Maze M, Dement WC, Edgar DM.

J Pharmacol Exp Ther. 1995 Oct;275(1):263-73.

PMID:
7562559
11.

Role of serotonergic neurotransmission in the hypnotic response to dexmedetomidine, an alpha 2-adrenoceptor agonist.

Rabin BC, Guo TZ, Gregg K, Maze M.

Eur J Pharmacol. 1996 Jun 13;306(1-3):51-9.

PMID:
8813614
12.

The nitric oxide-cGMP system of the locus coeruleus and the hypnotic action of alpha-2 adrenergic agonists.

Vulliemoz Y, Whittington RA, Virag L.

Brain Res. 1999 Dec 4;849(1-2):169-74.

PMID:
10592299
13.

Dexmedetomidine-induced sedation does not mimic the neurobehavioral phenotypes of sleep in Sprague Dawley rat.

Garrity AG, Botta S, Lazar SB, Swor E, Vanini G, Baghdoyan HA, Lydic R.

Sleep. 2015 Jan 1;38(1):73-84. doi: 10.5665/sleep.4328.

14.

Heterozygous alpha 2A-adrenergic receptor mice unveil unique therapeutic benefits of partial agonists.

Tan CM, Wilson MH, MacMillan LB, Kobilka BK, Limbird LE.

Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12471-6. Epub 2002 Aug 30.

15.

A hypnotic response to dexmedetomidine, an alpha 2 agonist, is mediated in the locus coeruleus in rats.

Correa-Sales C, Rabin BC, Maze M.

Anesthesiology. 1992 Jun;76(6):948-52.

PMID:
1350889
16.

Contribution of α2A-adrenoceptor subtype to effect of dexmedetomidine and xylazine on spinal synaptic transmission of mice.

Kobayashi T, Otsuguro K, Yamaguchi S, Ito S.

Eur J Pharmacol. 2015 Aug 15;761:321-9. doi: 10.1016/j.ejphar.2015.06.020. Epub 2015 Jun 16.

PMID:
26086861
17.

Hypnotic hypersensitivity to volatile anesthetics and dexmedetomidine in dopamine β-hydroxylase knockout mice.

Hu FY, Hanna GM, Han W, Mardini F, Thomas SA, Wyner AJ, Kelz MB.

Anesthesiology. 2012 Nov;117(5):1006-17. doi: 10.1097/ALN.0b013e3182700ab9.

18.

The effects of dexmedetomidine on perinatal excitotoxic brain injury are mediated by the alpha2A-adrenoceptor subtype.

Paris A, Mantz J, Tonner PH, Hein L, Brede M, Gressens P.

Anesth Analg. 2006 Feb;102(2):456-61.

PMID:
16428542
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20.
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