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Items: 1 to 20 of 101


DNA-PK/Chk2 induces centrosome amplification during prolonged replication stress.

Wang CY, Huang EY, Huang SC, Chung BC.

Oncogene. 2015 Mar 5;34(10):1263-9. doi: 10.1038/onc.2014.74. Epub 2014 Mar 24.


Distinct roles for DNA-PK, ATM and ATR in RPA phosphorylation and checkpoint activation in response to replication stress.

Liu S, Opiyo SO, Manthey K, Glanzer JG, Ashley AK, Amerin C, Troksa K, Shrivastav M, Nickoloff JA, Oakley GG.

Nucleic Acids Res. 2012 Nov;40(21):10780-94. doi: 10.1093/nar/gks849. Epub 2012 Sep 12.


DNA double-strand break formation upon UV-induced replication stress activates ATM and DNA-PKcs kinases.

Yajima H, Lee KJ, Zhang S, Kobayashi J, Chen BP.

J Mol Biol. 2009 Jan 23;385(3):800-10. doi: 10.1016/j.jmb.2008.11.036. Epub 2008 Nov 27.


DNA-activated protein kinase functions in a newly observed S phase checkpoint that links histone mRNA abundance with DNA replication.

Müller B, Blackburn J, Feijoo C, Zhao X, Smythe C.

J Cell Biol. 2007 Dec 31;179(7):1385-98. Epub 2007 Dec 24. Erratum in: J Cell Biol. 2008 Feb 25;180(4):843.


Distinct roles of ATR and DNA-PKcs in triggering DNA damage responses in ATM-deficient cells.

Tomimatsu N, Mukherjee B, Burma S.

EMBO Rep. 2009 Jun;10(6):629-35. doi: 10.1038/embor.2009.60. Epub 2009 May 15.


BRCA1 and FancJ cooperatively promote interstrand crosslinker induced centrosome amplification through the activation of polo-like kinase 1.

Zou J, Zhang D, Qin G, Chen X, Wang H, Zhang D.

Cell Cycle. 2014;13(23):3685-97. doi: 10.4161/15384101.2014.964973.


DNA damage induces Chk1-dependent centrosome amplification.

Bourke E, Dodson H, Merdes A, Cuffe L, Zachos G, Walker M, Gillespie D, Morrison CG.

EMBO Rep. 2007 Jun;8(6):603-9. Epub 2007 Apr 27.


ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling.

Stiff T, Walker SA, Cerosaletti K, Goodarzi AA, Petermann E, Concannon P, O'Driscoll M, Jeggo PA.

EMBO J. 2006 Dec 13;25(24):5775-82. Epub 2006 Nov 23.


Ataxia telangiectasia mutated (ATM) and ATM and Rad3-related protein exhibit selective target specificities in response to different forms of DNA damage.

Helt CE, Cliby WA, Keng PC, Bambara RA, O'Reilly MA.

J Biol Chem. 2005 Jan 14;280(2):1186-92. Epub 2004 Nov 8.


DNA-PK phosphorylation of RPA32 Ser4/Ser8 regulates replication stress checkpoint activation, fork restart, homologous recombination and mitotic catastrophe.

Ashley AK, Shrivastav M, Nie J, Amerin C, Troksa K, Glanzer JG, Liu S, Opiyo SO, Dimitrova DD, Le P, Sishc B, Bailey SM, Oakley GG, Nickoloff JA.

DNA Repair (Amst). 2014 Sep;21:131-9. doi: 10.1016/j.dnarep.2014.04.008. Epub 2014 May 10.


Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro.

Matsuoka S, Rotman G, Ogawa A, Shiloh Y, Tamai K, Elledge SJ.

Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10389-94.


DNA-PKcs is required to maintain stability of Chk1 and Claspin for optimal replication stress response.

Lin YF, Shih HY, Shang Z, Matsunaga S, Chen BP.

Nucleic Acids Res. 2014 Apr;42(7):4463-73. doi: 10.1093/nar/gku116. Epub 2014 Feb 5.


Chk1- and claspin-dependent but ATR/ATM- and Rad17-independent DNA replication checkpoint response in HeLa cells.

Rodríguez-Bravo V, Guaita-Esteruelas S, Florensa R, Bachs O, Agell N.

Cancer Res. 2006 Sep 1;66(17):8672-9.


DNA protein kinase-dependent G2 checkpoint revealed following knockdown of ataxia-telangiectasia mutated in human mammary epithelial cells.

Arlander SJ, Greene BT, Innes CL, Paules RS.

Cancer Res. 2008 Jan 1;68(1):89-97. doi: 10.1158/0008-5472.CAN-07-0675.


Inactivation of DNA-dependent protein kinase leads to spindle disruption and mitotic catastrophe with attenuated checkpoint protein 2 Phosphorylation in response to DNA damage.

Shang ZF, Huang B, Xu QZ, Zhang SM, Fan R, Liu XD, Wang Y, Zhou PK.

Cancer Res. 2010 May 1;70(9):3657-66. doi: 10.1158/0008-5472.CAN-09-3362. Epub 2010 Apr 20.

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