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Items: 1 to 20 of 237

1.

Acyl-CoA:cholesterol acyltransferase 1 mediates liver fibrosis by regulating free cholesterol accumulation in hepatic stellate cells.

Tomita K, Teratani T, Suzuki T, Shimizu M, Sato H, Narimatsu K, Usui S, Furuhashi H, Kimura A, Nishiyama K, Maejima T, Okada Y, Kurihara C, Shimamura K, Ebinuma H, Saito H, Yokoyama H, Watanabe C, Komoto S, Nagao S, Sugiyama K, Aosasa S, Hatsuse K, Yamamoto J, Hibi T, Miura S, Hokari R, Kanai T.

J Hepatol. 2014 Jul;61(1):98-106. doi: 10.1016/j.jhep.2014.03.018. Epub 2014 Mar 18.

PMID:
24657401
2.

A high-cholesterol diet exacerbates liver fibrosis in mice via accumulation of free cholesterol in hepatic stellate cells.

Teratani T, Tomita K, Suzuki T, Oshikawa T, Yokoyama H, Shimamura K, Tominaga S, Hiroi S, Irie R, Okada Y, Kurihara C, Ebinuma H, Saito H, Hokari R, Sugiyama K, Kanai T, Miura S, Hibi T.

Gastroenterology. 2012 Jan;142(1):152-164.e10. doi: 10.1053/j.gastro.2011.09.049. Epub 2011 Oct 10.

PMID:
21995947
3.

Free cholesterol accumulation in hepatic stellate cells: mechanism of liver fibrosis aggravation in nonalcoholic steatohepatitis in mice.

Tomita K, Teratani T, Suzuki T, Shimizu M, Sato H, Narimatsu K, Okada Y, Kurihara C, Irie R, Yokoyama H, Shimamura K, Usui S, Ebinuma H, Saito H, Watanabe C, Komoto S, Kawaguchi A, Nagao S, Sugiyama K, Hokari R, Kanai T, Miura S, Hibi T.

Hepatology. 2014 Jan;59(1):154-69. doi: 10.1002/hep.26604. Epub 2013 Nov 18.

PMID:
23832448
4.
5.

Interleukin-17A plays a pivotal role in cholestatic liver fibrosis in mice.

Hara M, Kono H, Furuya S, Hirayama K, Tsuchiya M, Fujii H.

J Surg Res. 2013 Aug;183(2):574-82. doi: 10.1016/j.jss.2013.03.025. Epub 2013 Mar 28.

PMID:
23578751
6.

Functional linkage of cirrhosis-predictive single nucleotide polymorphisms of Toll-like receptor 4 to hepatic stellate cell responses.

Guo J, Loke J, Zheng F, Hong F, Yea S, Fukata M, Tarocchi M, Abar OT, Huang H, Sninsky JJ, Friedman SL.

Hepatology. 2009 Mar;49(3):960-8. doi: 10.1002/hep.22697.

7.

Tumor necrosis factor-α promotes cholestasis-induced liver fibrosis in the mouse through tissue inhibitor of metalloproteinase-1 production in hepatic stellate cells.

Osawa Y, Hoshi M, Yasuda I, Saibara T, Moriwaki H, Kozawa O.

PLoS One. 2013 Jun 3;8(6):e65251. doi: 10.1371/journal.pone.0065251. Print 2013.

8.

Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice.

Meng F, Wang K, Aoyama T, Grivennikov SI, Paik Y, Scholten D, Cong M, Iwaisako K, Liu X, Zhang M, Osterreicher CH, Stickel F, Ley K, Brenner DA, Kisseleva T.

Gastroenterology. 2012 Sep;143(3):765-76.e1-3. doi: 10.1053/j.gastro.2012.05.049. Epub 2012 Jun 8.

9.

Tumor progression locus 2/Cot is required for activation of extracellular regulated kinase in liver injury and toll-like receptor-induced TIMP-1 gene transcription in hepatic stellate cells in mice.

Perugorria MJ, Murphy LB, Fullard N, Chakraborty JB, Vyrla D, Wilson CL, Oakley F, Mann J, Mann DA.

Hepatology. 2013 Mar;57(3):1238-49. doi: 10.1002/hep.26108.

10.

Activation of toll-like receptor 3 attenuates alcoholic liver injury by stimulating Kupffer cells and stellate cells to produce interleukin-10 in mice.

Byun JS, Suh YG, Yi HS, Lee YS, Jeong WI.

J Hepatol. 2013 Feb;58(2):342-9. doi: 10.1016/j.jhep.2012.09.016. Epub 2012 Sep 27.

PMID:
23023014
11.

Deficiency of NOX1 or NOX4 Prevents Liver Inflammation and Fibrosis in Mice through Inhibition of Hepatic Stellate Cell Activation.

Lan T, Kisseleva T, Brenner DA.

PLoS One. 2015 Jul 29;10(7):e0129743. doi: 10.1371/journal.pone.0129743. eCollection 2015.

12.

Role of TGF-β signaling in differentiation of mesothelial cells to vitamin A-poor hepatic stellate cells in liver fibrosis.

Li Y, Lua I, French SW, Asahina K.

Am J Physiol Gastrointest Liver Physiol. 2016 Feb 15;310(4):G262-72. doi: 10.1152/ajpgi.00257.2015. Epub 2015 Dec 23.

PMID:
26702136
13.

MicroRNA-101 suppresses liver fibrosis by targeting the TGFβ signalling pathway.

Tu X, Zhang H, Zhang J, Zhao S, Zheng X, Zhang Z, Zhu J, Chen J, Dong L, Zang Y, Zhang J.

J Pathol. 2014 Sep;234(1):46-59. doi: 10.1002/path.4373. Epub 2014 Jun 17.

PMID:
24817606
14.

Fibronectin protects from excessive liver fibrosis by modulating the availability of and responsiveness of stellate cells to active TGF-β.

Kawelke N, Vasel M, Sens C, Au Av, Dooley S, Nakchbandi IA.

PLoS One. 2011;6(11):e28181. doi: 10.1371/journal.pone.0028181. Epub 2011 Nov 28.

15.

Semaphorin 7A contributes to TGF-β-mediated liver fibrogenesis.

De Minicis S, Rychlicki C, Agostinelli L, Saccomanno S, Trozzi L, Candelaresi C, Bataller R, Millán C, Brenner DA, Vivarelli M, Mocchegiani F, Marzioni M, Benedetti A, Svegliati-Baroni G.

Am J Pathol. 2013 Sep;183(3):820-30. doi: 10.1016/j.ajpath.2013.05.030. Epub 2013 Jul 11.

PMID:
23850082
16.

TLR4 enhances TGF-beta signaling and hepatic fibrosis.

Seki E, De Minicis S, Osterreicher CH, Kluwe J, Osawa Y, Brenner DA, Schwabe RF.

Nat Med. 2007 Nov;13(11):1324-32. Epub 2007 Oct 21.

PMID:
17952090
17.

Fibromodulin, an oxidative stress-sensitive proteoglycan, regulates the fibrogenic response to liver injury in mice.

Mormone E, Lu Y, Ge X, Fiel MI, Nieto N.

Gastroenterology. 2012 Mar;142(3):612-621.e5. doi: 10.1053/j.gastro.2011.11.029. Epub 2011 Dec 1.

18.

IFN-γ deficiency attenuates hepatic inflammation and fibrosis in a steatohepatitis model induced by a methionine- and choline-deficient high-fat diet.

Luo XY, Takahara T, Kawai K, Fujino M, Sugiyama T, Tsuneyama K, Tsukada K, Nakae S, Zhong L, Li XK.

Am J Physiol Gastrointest Liver Physiol. 2013 Dec;305(12):G891-9. doi: 10.1152/ajpgi.00193.2013. Epub 2013 Oct 17.

19.

Angiotensin-II type 1 receptor-mediated Janus kinase 2 activation induces liver fibrosis.

Granzow M, Schierwagen R, Klein S, Kowallick B, Huss S, Linhart M, Mazar IG, Görtzen J, Vogt A, Schildberg FA, Gonzalez-Carmona MA, Wojtalla A, Krämer B, Nattermann J, Siegmund SV, Werner N, Fürst DO, Laleman W, Knolle P, Shah VH, Sauerbruch T, Trebicka J.

Hepatology. 2014 Jul;60(1):334-48. doi: 10.1002/hep.27117. Epub 2014 May 6.

PMID:
24619965
20.

Treatment with 4-methylpyrazole modulated stellate cells and natural killer cells and ameliorated liver fibrosis in mice.

Yi HS, Eun HS, Lee YS, Jung JY, Park SH, Park KG, Choi HS, Suh JM, Jeong WI.

PLoS One. 2015 May 29;10(5):e0127946. doi: 10.1371/journal.pone.0127946. eCollection 2015.

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