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Items: 1 to 20 of 90

1.

Reductions in myeloid-derived suppressor cells and lung metastases using AZD4547 treatment of a metastatic murine breast tumor model.

Liu L, Ye TH, Han YP, Song H, Zhang YK, Xia Y, Wang NY, Xiong Y, Song XJ, Zhu YX, Li de L, Zeng J, Ran K, Peng CT, Wei YQ, Yu LT.

Cell Physiol Biochem. 2014;33(3):633-45. doi: 10.1159/000358640. Epub 2014 Mar 4.

PMID:
24642893
2.

Inhibition of FGFR signaling by PD173074 improves antitumor immunity and impairs breast cancer metastasis.

Ye T, Wei X, Yin T, Xia Y, Li D, Shao B, Song X, He S, Luo M, Gao X, He Z, Luo C, Xiong Y, Wang N, Zeng J, Zhao L, Shen G, Xie Y, Yu L, Wei Y.

Breast Cancer Res Treat. 2014 Feb;143(3):435-46. doi: 10.1007/s10549-013-2829-y. Epub 2014 Jan 8.

PMID:
24398778
3.

A novel cinnamide YLT26 induces breast cancer cells apoptosis via ROS-mitochondrial apoptotic pathway in vitro and inhibits lung metastasis in vivo.

Xiong Y, Ye T, Wang M, Xia Y, Wang N, Song X, Wang F, Liu L, Zhu Y, Yang F, Wei Y, Yu L.

Cell Physiol Biochem. 2014;34(6):1863-76. doi: 10.1159/000366385. Epub 2014 Nov 21.

PMID:
25503322
4.

Translating the therapeutic potential of AZD4547 in FGFR1-amplified non-small cell lung cancer through the use of patient-derived tumor xenograft models.

Zhang J, Zhang L, Su X, Li M, Xie L, Malchers F, Fan S, Yin X, Xu Y, Liu K, Dong Z, Zhu G, Qian Z, Tang L, Schöttle J, Zhan P, Ji Q, Kilgour E, Smith PD, Brooks AN, Thomas RK, Gavine PR.

Clin Cancer Res. 2012 Dec 15;18(24):6658-67. doi: 10.1158/1078-0432.CCR-12-2694. Epub 2012 Oct 18. Erratum in: Clin Cancer Res. 2013 Jul 1;19(13):3714. Schöttle, Jakob [added].

5.

FGFR2 gene amplification in gastric cancer predicts sensitivity to the selective FGFR inhibitor AZD4547.

Xie L, Su X, Zhang L, Yin X, Tang L, Zhang X, Xu Y, Gao Z, Liu K, Zhou M, Gao B, Shen D, Zhang L, Ji J, Gavine PR, Zhang J, Kilgour E, Zhang X, Ji Q.

Clin Cancer Res. 2013 May 1;19(9):2572-83. doi: 10.1158/1078-0432.CCR-12-3898. Epub 2013 Mar 14.

6.

Serum inhibits the immunosuppressive function of myeloid-derived suppressor cells isolated from 4T1 tumor-bearing mice.

Hamilton MJ, Banáth JP, Lam V, Lepard NE, Krystal G, Bennewith KL.

Cancer Immunol Immunother. 2012 May;61(5):643-54. doi: 10.1007/s00262-011-1125-0. Epub 2011 Oct 22.

PMID:
22021068
8.

Targeting fibroblast growth factor receptors blocks PI3K/AKT signaling, induces apoptosis, and impairs mammary tumor outgrowth and metastasis.

Dey JH, Bianchi F, Voshol J, Bonenfant D, Oakeley EJ, Hynes NE.

Cancer Res. 2010 May 15;70(10):4151-62. doi: 10.1158/0008-5472.CAN-09-4479. Epub 2010 May 11.

9.

Aminoacyl-tRNA synthetase-interacting multifunctional protein 1 suppresses tumor growth in breast cancer-bearing mice by negatively regulating myeloid-derived suppressor cell functions.

Hong HJ, Lim HX, Song JH, Lee A, Kim E, Cho D, Cohen EP, Kim TS.

Cancer Immunol Immunother. 2016 Jan;65(1):61-72. doi: 10.1007/s00262-015-1777-2. Epub 2015 Nov 27.

PMID:
26613952
10.

Core needle biopsy of breast cancer tumors increases distant metastases in a mouse model.

Mathenge EG, Dean CA, Clements D, Vaghar-Kashani A, Photopoulos S, Coyle KM, Giacomantonio M, Malueth B, Nunokawa A, Jordan J, Lewis JD, Gujar SA, Marcato P, Lee PW, Giacomantonio CA.

Neoplasia. 2014 Nov 20;16(11):950-60. doi: 10.1016/j.neo.2014.09.004. eCollection 2014 Nov.

11.

Zoledronic acid inhibits visceral metastases in the 4T1/luc mouse breast cancer model.

Hiraga T, Williams PJ, Ueda A, Tamura D, Yoneda T.

Clin Cancer Res. 2004 Jul 1;10(13):4559-67.

12.

Macrophages are more potent immune suppressors ex vivo than immature myeloid-derived suppressor cells induced by metastatic murine mammary carcinomas.

Hamilton MJ, Bosiljcic M, Lepard NE, Halvorsen EC, Ho VW, Banáth JP, Krystal G, Bennewith KL.

J Immunol. 2014 Jan 1;192(1):512-22. doi: 10.4049/jimmunol.1300096. Epub 2013 Nov 27.

13.

AZD4547: an orally bioavailable, potent, and selective inhibitor of the fibroblast growth factor receptor tyrosine kinase family.

Gavine PR, Mooney L, Kilgour E, Thomas AP, Al-Kadhimi K, Beck S, Rooney C, Coleman T, Baker D, Mellor MJ, Brooks AN, Klinowska T.

Cancer Res. 2012 Apr 15;72(8):2045-56. doi: 10.1158/0008-5472.CAN-11-3034. Epub 2012 Feb 27.

14.

Silibinin inhibits accumulation of myeloid-derived suppressor cells and tumor growth of murine breast cancer.

Forghani P, Khorramizadeh MR, Waller EK.

Cancer Med. 2014 Apr;3(2):215-24. doi: 10.1002/cam4.186. Epub 2014 Jan 20.

15.
16.

MDSC as a mechanism of tumor escape from sunitinib mediated anti-angiogenic therapy.

Finke J, Ko J, Rini B, Rayman P, Ireland J, Cohen P.

Int Immunopharmacol. 2011 Jul;11(7):856-61. doi: 10.1016/j.intimp.2011.01.030. Epub 2011 Feb 11.

17.

An orally active small molecule TGF-beta receptor I antagonist inhibits the growth of metastatic murine breast cancer.

Rausch MP, Hahn T, Ramanathapuram L, Bradley-Dunlop D, Mahadevan D, Mercado-Pimentel ME, Runyan RB, Besselsen DG, Zhang X, Cheung HK, Lee WC, Ling LE, Akporiaye ET.

Anticancer Res. 2009 Jun;29(6):2099-109.

18.

Interleukin-33/ST2 axis promotes breast cancer growth and metastases by facilitating intratumoral accumulation of immunosuppressive and innate lymphoid cells.

Jovanovic IP, Pejnovic NN, Radosavljevic GD, Pantic JM, Milovanovic MZ, Arsenijevic NN, Lukic ML.

Int J Cancer. 2014 Apr 1;134(7):1669-82. doi: 10.1002/ijc.28481. Epub 2013 Oct 10.

19.

Identification of a myeloid-derived suppressor cell cystatin-like protein that inhibits metastasis.

Boutté AM, Friedman DB, Bogyo M, Min Y, Yang L, Lin PC.

FASEB J. 2011 Aug;25(8):2626-37. doi: 10.1096/fj.10-180604. Epub 2011 Apr 25.

20.

Gemcitabine directly inhibits myeloid derived suppressor cells in BALB/c mice bearing 4T1 mammary carcinoma and augments expansion of T cells from tumor-bearing mice.

Le HK, Graham L, Cha E, Morales JK, Manjili MH, Bear HD.

Int Immunopharmacol. 2009 Jul;9(7-8):900-9. doi: 10.1016/j.intimp.2009.03.015. Epub 2009 Mar 29.

PMID:
19336265
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