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Items: 1 to 20 of 109

1.

Discovery of N-substituted 3-arylisoquinolone derivatives as antitumor agents originating from O-substituted 3-arylisoquinolines via [2,3] or [3,3] rearrangement.

Li B, Wang G, Xu Z, Zhang Y, Huang X, Zeng B, Chen K, Shi J, Wang H, Zhu W.

Eur J Med Chem. 2014 Apr 22;77:204-10. doi: 10.1016/j.ejmech.2014.03.008. Epub 2014 Mar 6.

PMID:
24637214
2.

Overman rearrangement and Pomeranz-Fritsch reaction for the synthesis of benzoazepinoisoquinolones to discover novel antitumor agents.

Li B, Wang G, Yang M, Xu Z, Zeng B, Wang H, Shen J, Chen K, Zhu W.

Eur J Med Chem. 2013;70:677-84. doi: 10.1016/j.ejmech.2013.10.049. Epub 2013 Oct 25.

PMID:
24215818
3.

Synthesis and biological evaluation of 3-arylisoquinolines as antitumor agents.

Cho WJ, Park MJ, Chung BH, Lee CO.

Bioorg Med Chem Lett. 1998 Jan 6;8(1):41-6.

PMID:
9871625
4.

Topoisomerase I-mediated DNA cleavage as a guide to the development of antitumor agents derived from the marine alkaloid lamellarin D: triester derivatives incorporating amino acid residues.

Tardy C, Facompré M, Laine W, Baldeyrou B, García-Gravalos D, Francesch A, Mateo C, Pastor A, Jiménez JA, Manzanares I, Cuevas C, Bailly C.

Bioorg Med Chem. 2004 Apr 1;12(7):1697-712.

PMID:
15028262
5.

Synthesis and cytotoxicity of (+/-)-7,9-dideoxy-pancratistatin analogues.

Nieto-García O, Alonso R.

Org Biomol Chem. 2013 Jan 21;11(3):515-22. doi: 10.1039/c2ob27127c. Epub 2012 Dec 3.

PMID:
23207545
6.

Synthesis and biological evaluations of novel indenoisoquinolines as topoisomerase I inhibitors.

Zhang X, Wang R, Zhao L, Lu N, Wang J, You Q, Li Z, Guo Q.

Bioorg Med Chem Lett. 2012 Jan 15;22(2):1276-81. doi: 10.1016/j.bmcl.2011.10.019. Epub 2011 Oct 24.

PMID:
22079759
7.

Discovery of novel 1,5-benzodiazepine-2,4-dione derivatives as potential anticancer agents.

Chen Y, Le V, Xu X, Shao X, Liu J, Li Z.

Bioorg Med Chem Lett. 2014 Aug 15;24(16):3948-51. doi: 10.1016/j.bmcl.2014.06.041. Epub 2014 Jun 25.

PMID:
25017036
8.

Chemistry of ecteinascidins. Part 3: preparation of 2'-N-acyl derivatives of ecteinascidin 770 and evaluation of cytotoxicity.

Saktrakulkla P, Toriumi S, Tsujimoto M, Patarapanich C, Suwanborirux K, Saito N.

Bioorg Med Chem. 2011 Aug 1;19(15):4421-36. doi: 10.1016/j.bmc.2011.06.047. Epub 2011 Jun 21. Erratum in: Bioorg Med Chem. 2012 Jan 1;20(1):531.

PMID:
21752654
9.

Synthesis of C-1 homologues of pancratistatin and their preliminary biological evaluation.

Vshyvenko S, Scattolon J, Hudlicky T, Romero AE, Kornienko A.

Bioorg Med Chem Lett. 2011 Aug 15;21(16):4750-2. doi: 10.1016/j.bmcl.2011.06.068. Epub 2011 Jun 22.

10.

Synthesis of benzo[3,4]azepino[1,2-b]isoquinolin-9-ones from 3-arylisoquinolines via ring closing metathesis and evaluation of topoisomerase I inhibitory activity, cytotoxicity and docking study.

Van HT, Khadka DB, Yang SH, Le TN, Cho SH, Zhao C, Lee IS, Kwon Y, Lee KT, Kim YC, Cho WJ.

Bioorg Med Chem. 2011 Sep 15;19(18):5311-20. doi: 10.1016/j.bmc.2011.08.006. Epub 2011 Aug 8.

PMID:
21873069
11.

Synthesis and structure-activity relationships of new benzodioxinic lactones as potential anticancer drugs.

Romero M, Renard P, Caignard DH, Atassi G, Solans X, Constans P, Bailly C, Pujol MD.

J Med Chem. 2007 Jan 25;50(2):294-307.

PMID:
17228871
12.

Synthesis of 5,6-dihydropyrrolo[2,1-a]isoquinolines featuring an intramolecular radical-oxidative cyclization of polysubstituted pyrroles, and evaluation of their cytotoxic activity.

Reyes-Gutiérrez PE, Camacho JR, Ramírez-Apan MT, Osornio YM, Martínez R.

Org Biomol Chem. 2010 Oct 7;8(19):4374-82. doi: 10.1039/c004399k. Epub 2010 Jul 29.

PMID:
20672155
13.

5-Substituted [1]pyrindine derivatives with antiproliferative activity.

Kolb S, Goddard ML, Loukaci A, Mondésert O, Ducommun B, Braud E, Garbay C.

Eur J Med Chem. 2010 Mar;45(3):896-901. doi: 10.1016/j.ejmech.2009.11.028. Epub 2009 Dec 6.

PMID:
19969400
14.

Anti-tumor activity of novel biisoquinoline derivatives against breast cancers.

Jaiswal AS, Hirsch-Weil D, Proulx ER, Hong S, Narayan S.

Bioorg Med Chem Lett. 2014 Oct 15;24(20):4850-3. doi: 10.1016/j.bmcl.2014.08.053. Epub 2014 Sep 2.

PMID:
25240616
15.

[Synthesis and structure-activity relationship of N-(2-arylethyl) isoquinoline derivatives as anti-cancer agents].

Wang YX, Zhao WL, Bi CW, Li YB, Shao RG, Song DQ.

Yao Xue Xue Bao. 2012 Feb;47(2):200-5. Chinese.

PMID:
22512031
16.

Design, synthesis and biological activity of piperlongumine derivatives as selective anticancer agents.

Wu Y, Min X, Zhuang C, Li J, Yu Z, Dong G, Yao J, Wang S, Liu Y, Wu S, Zhu S, Sheng C, Wei Y, Zhang H, Zhang W, Miao Z.

Eur J Med Chem. 2014 Jul 23;82:545-51. doi: 10.1016/j.ejmech.2014.05.070. Epub 2014 Jun 2.

PMID:
24937186
17.

Synthesis of new 3-arylisoquinolinamines: effect on topoisomerase I inhibition and cytotoxicity.

Cho WJ, Min SY, Le TN, Kim TS.

Bioorg Med Chem Lett. 2003 Dec 15;13(24):4451-4.

PMID:
14643344
18.

Synthesis of novel substituted purine derivatives and identification of the cell death mechanism.

Demir Z, Guven EB, Ozbey S, Kazak C, Atalay RC, Tuncbilek M.

Eur J Med Chem. 2015 Jan 7;89:701-20. doi: 10.1016/j.ejmech.2014.10.080. Epub 2014 Oct 30.

PMID:
25462277
19.

Discovery of antiglioma activity of biaryl 1,2,3,4-tetrahydroisoquinoline derivatives and conformationally flexible analogues.

Mohler ML, Kang GS, Hong SS, Patil R, Kirichenko OV, Li W, Rakov IM, Geisert EE, Miller DD.

J Med Chem. 2006 Sep 21;49(19):5845-8.

PMID:
16970409
20.

Synthesis and structure-activity relationship studies of substituted isoquinoline analogs as antitumor agent.

Cheon SH, Park JS, Chung BH, Choi BG, Cho WJ, Choi SU, Lee CO.

Arch Pharm Res. 1998 Apr;21(2):193-7.

PMID:
9875430
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