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SIRT1 protects against cigarette smoke-induced lung oxidative stress via a FOXO3-dependent mechanism.

Yao H, Sundar IK, Ahmad T, Lerner C, Gerloff J, Friedman AE, Phipps RP, Sime PJ, McBurney MW, Guarente L, Rahman I.

Am J Physiol Lung Cell Mol Physiol. 2014 May 1;306(9):L816-28. doi: 10.1152/ajplung.00323.2013. Epub 2014 Mar 14.


SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice.

Yao H, Chung S, Hwang JW, Rajendrasozhan S, Sundar IK, Dean DA, McBurney MW, Guarente L, Gu W, Rönty M, Kinnula VL, Rahman I.

J Clin Invest. 2012 Jun;122(6):2032-45. doi: 10.1172/JCI60132. Epub 2012 May 1.


Trolox contributes to Nrf2-mediated protection of human and murine primary alveolar type II cells from injury by cigarette smoke.

Messier EM, Bahmed K, Tuder RM, Chu HW, Bowler RP, Kosmider B.

Cell Death Dis. 2013 Apr 4;4:e573. doi: 10.1038/cddis.2013.96.


Expression of concern: Decline in NRF2-regulated antioxidants in chronic obstructive pulmonary disease lungs due to loss of its positive regulator, DJ-1.

Malhotra D, Thimmulappa R, Navas-Acien A, Sandford A, Elliott M, Singh A, Chen L, Zhuang X, Hogg J, Pare P, Tuder RM, Biswal S.

Am J Respir Crit Care Med. 2008 Sep 15;178(6):592-604. doi: 10.1164/rccm.200803-380OC. Epub 2008 Jun 12. Erratum in: Am J Respir Crit Care Med. 2009 Apr 1;179(7):624.


SIRT1 redresses the imbalance of tissue inhibitor of matrix metalloproteinase-1 and matrix metalloproteinase-9 in the development of mouse emphysema and human COPD.

Yao H, Hwang JW, Sundar IK, Friedman AE, McBurney MW, Guarente L, Gu W, Kinnula VL, Rahman I.

Am J Physiol Lung Cell Mol Physiol. 2013 Nov 1;305(9):L615-24. doi: 10.1152/ajplung.00249.2012. Epub 2013 Sep 13.


The influence of 5-lipoxygenase on cigarette smoke-induced emphysema in mice.

Kennedy-Feitosa E, Pinto RF, Pires KM, Monteiro AP, Machado MN, Santos JC, Ribeiro ML, Zin WA, Canetti CA, Romana-Souza B, Porto LC, Valenca SS.

Biochim Biophys Acta. 2014 Jan;1840(1):199-208. doi: 10.1016/j.bbagen.2013.09.028. Epub 2013 Sep 26.


Circadian clock function is disrupted by environmental tobacco/cigarette smoke, leading to lung inflammation and injury via a SIRT1-BMAL1 pathway.

Hwang JW, Sundar IK, Yao H, Sellix MT, Rahman I.

FASEB J. 2014 Jan;28(1):176-94. doi: 10.1096/fj.13-232629. Epub 2013 Sep 11.


Expression of concern: Heightened endoplasmic reticulum stress in the lungs of patients with chronic obstructive pulmonary disease: the role of Nrf2-regulated proteasomal activity.

Malhotra D, Thimmulappa R, Vij N, Navas-Acien A, Sussan T, Merali S, Zhang L, Kelsen SG, Myers A, Wise R, Tuder R, Biswal S.

Am J Respir Crit Care Med. 2009 Dec 15;180(12):1196-207. doi: 10.1164/rccm.200903-0324OC. Epub 2009 Oct 1.


Deletion of Keap1 in the lung attenuates acute cigarette smoke-induced oxidative stress and inflammation.

Blake DJ, Singh A, Kombairaju P, Malhotra D, Mariani TJ, Tuder RM, Gabrielson E, Biswal S.

Am J Respir Cell Mol Biol. 2010 May;42(5):524-36. doi: 10.1165/rcmb.2009-0054OC. Epub 2009 Jun 11.


Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice.

Sussan TE, Rangasamy T, Blake DJ, Malhotra D, El-Haddad H, Bedja D, Yates MS, Kombairaju P, Yamamoto M, Liby KT, Sporn MB, Gabrielson KL, Champion HC, Tuder RM, Kensler TW, Biswal S.

Proc Natl Acad Sci U S A. 2009 Jan 6;106(1):250-5. doi: 10.1073/pnas.0804333106. Epub 2008 Dec 22.


The transcriptome of Nrf2-/- mice provides evidence for impaired cell cycle progression in the development of cigarette smoke-induced emphysematous changes.

Gebel S, Diehl S, Pype J, Friedrichs B, Weiler H, Schüller J, Xu H, Taguchi K, Yamamoto M, Müller T.

Toxicol Sci. 2010 May;115(1):238-52. doi: 10.1093/toxsci/kfq039. Epub 2010 Feb 4.


N-acetylcysteine protects murine alveolar type II cells from cigarette smoke injury in a nuclear erythroid 2-related factor-2-independent manner.

Messier EM, Day BJ, Bahmed K, Kleeberger SR, Tuder RM, Bowler RP, Chu HW, Mason RJ, Kosmider B.

Am J Respir Cell Mol Biol. 2013 May;48(5):559-67. doi: 10.1165/rcmb.2012-0295OC. Erratum in: Am J Respir Cell Mol Biol. 2013 Jul;49(1):165. Bahmed, Karim [added].


SIRT1 is a redox-sensitive deacetylase that is post-translationally modified by oxidants and carbonyl stress.

Caito S, Rajendrasozhan S, Cook S, Chung S, Yao H, Friedman AE, Brookes PS, Rahman I.

FASEB J. 2010 Sep;24(9):3145-59. doi: 10.1096/fj.09-151308. Epub 2010 Apr 12.


Cigarette smoke-induced autophagy is regulated by SIRT1-PARP-1-dependent mechanism: implication in pathogenesis of COPD.

Hwang JW, Chung S, Sundar IK, Yao H, Arunachalam G, McBurney MW, Rahman I.

Arch Biochem Biophys. 2010 Aug 15;500(2):203-9. doi: 10.1016/ Epub 2010 May 20.


Andrographolide protects against cigarette smoke-induced oxidative lung injury via augmentation of Nrf2 activity.

Guan SP, Tee W, Ng DS, Chan TK, Peh HY, Ho WE, Cheng C, Mak JC, Wong WS.

Br J Pharmacol. 2013 Apr;168(7):1707-18. doi: 10.1111/bph.12054.


FOXO3 deficiency leads to increased susceptibility to cigarette smoke-induced inflammation, airspace enlargement, and chronic obstructive pulmonary disease.

Hwang JW, Rajendrasozhan S, Yao H, Chung S, Sundar IK, Huyck HL, Pryhuber GS, Kinnula VL, Rahman I.

J Immunol. 2011 Jul 15;187(2):987-98. doi: 10.4049/jimmunol.1001861. Epub 2011 Jun 20.


Tocopherol transfer protein deficiency modifies nuclear receptor transcriptional networks in lungs: modulation by cigarette smoke in vivo.

Gohil K, Oommen S, Vasu VT, Aung HH, Cross CE.

Mol Aspects Med. 2007 Oct-Dec;28(5-6):453-80. Epub 2007 Feb 24.


Icaritin attenuates cigarette smoke-mediated oxidative stress in human lung epithelial cells via activation of PI3K-AKT and Nrf2 signaling.

Wu J, Xu H, Wong PF, Xia S, Xu J, Dong J.

Food Chem Toxicol. 2014 Feb;64:307-13. doi: 10.1016/j.fct.2013.12.006. Epub 2013 Dec 8.


Distal airways in mice exposed to cigarette smoke: Nrf2-regulated genes are increased in Clara cells.

Adair-Kirk TL, Atkinson JJ, Griffin GL, Watson MA, Kelley DG, DeMello D, Senior RM, Betsuyaku T.

Am J Respir Cell Mol Biol. 2008 Oct;39(4):400-11. doi: 10.1165/rcmb.2007-0295OC. Epub 2008 Apr 25.


Extracellular superoxide dismutase protects against pulmonary emphysema by attenuating oxidative fragmentation of ECM.

Yao H, Arunachalam G, Hwang JW, Chung S, Sundar IK, Kinnula VL, Crapo JD, Rahman I.

Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15571-6. doi: 10.1073/pnas.1007625107. Epub 2010 Aug 16.

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