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Reduction of TLR4 mRNA stability and protein expressions through inhibiting cytoplasmic translocation of HuR transcription factor by E₂ and/or ERα in LPS-treated H9c2 cardiomyoblast cells.

Fan MJ, Huang-Liu R, Shen CY, Ju DT, Lin YM, Pai P, Huang PY, Ho TJ, Tsai FJ, Tsai CH, Huang CY.

Chin J Physiol. 2014 Feb 28;57(1):8-18. doi: 10.4077/CJP.2014.BAC197.


The role of human antigen R, an RNA-binding protein, in mediating the stabilization of toll-like receptor 4 mRNA induced by endotoxin: a novel mechanism involved in vascular inflammation.

Lin FY, Chen YH, Lin YW, Tsai JS, Chen JW, Wang HJ, Chen YL, Li CY, Lin SJ.

Arterioscler Thromb Vasc Biol. 2006 Dec;26(12):2622-9. Epub 2006 Sep 21.


Akt mediates 17beta-estradiol and/or estrogen receptor-alpha inhibition of LPS-induced tumor necresis factor-alpha expression and myocardial cell apoptosis by suppressing the JNK1/2-NFkappaB pathway.

Liu CJ, Lo JF, Kuo CH, Chu CH, Chen LM, Tsai FJ, Tsai CH, Tzang BS, Kuo WW, Huang CY.

J Cell Mol Med. 2009 Sep;13(9B):3655-67. doi: 10.1111/j.1582-4934.2009.00669.x.


Hu antigen R and tristetraprolin: counter-regulators of rat apical sodium-dependent bile acid transporter by way of effects on messenger RNA stability.

Chen F, Shyu AB, Shneider BL.

Hepatology. 2011 Oct;54(4):1371-8. doi: 10.1002/hep.24496. Epub 2011 Aug 9. Erratum in: Hepatology. 2014 Feb;59(2):740.


Salvianolic acid B inhibits the TLR4-NFκB-TNFα pathway and attenuates neonatal rat cardiomyocyte injury induced by lipopolysaccharide.

Wang J, Zhang Y, Guo LL, Wu GJ, Liu RH.

Chin J Integr Med. 2011 Oct;17(10):775-9. doi: 10.1007/s11655-011-0877-x. Epub 2011 Nov 19.


Carthamus tinctorius L. prevents LPS-induced TNFalpha signaling activation and cell apoptosis through JNK1/2-NFkappaB pathway inhibition in H9c2 cardiomyoblast cells.

Tien YC, Lin JY, Lai CH, Kuo CH, Lin WY, Tsai CH, Tsai FJ, Cheng YC, Peng WH, Huang CY.

J Ethnopharmacol. 2010 Aug 9;130(3):505-13. doi: 10.1016/j.jep.2010.05.038. Epub 2010 Jun 9.


Chronic ethanol exposure increases the binding of HuR to the TNFalpha 3'-untranslated region in macrophages.

McMullen MR, Cocuzzi E, Hatzoglou M, Nagy LE.

J Biol Chem. 2003 Oct 3;278(40):38333-41. Epub 2003 Jul 21.


Lipopolysaccharide enhances decorin expression through the Toll-like receptor 4, myeloid differentiating factor 88, nuclear factor-kappa B, and mitogen-activated protein kinase pathways in odontoblast cells.

He W, Qu T, Yu Q, Wang Z, Wang H, Zhang J, Smith AJ.

J Endod. 2012 Apr;38(4):464-9. doi: 10.1016/j.joen.2011.12.021. Epub 2012 Jan 31.


HuR post-transcriptionally regulates TNF-α-induced IL-6 expression in human pulmonary microvascular endothelial cells mainly via tristetraprolin.

Shi JX, Su X, Xu J, Zhang WY, Shi Y.

Respir Physiol Neurobiol. 2012 Apr 30;181(2):154-61. doi: 10.1016/j.resp.2012.02.011. Epub 2012 Mar 7.


The RNA-binding protein HuR stabilizes cytosolic phospholipase A2α mRNA under interleukin-1β treatment in non-small cell lung cancer A549 Cells.

Liao WL, Wang WC, Chang WC, Tseng JT.

J Biol Chem. 2011 Oct 14;286(41):35499-508. doi: 10.1074/jbc.M111.263582. Epub 2011 Aug 23.


Polyamines regulate the stability of activating transcription factor-2 mRNA through RNA-binding protein HuR in intestinal epithelial cells.

Xiao L, Rao JN, Zou T, Liu L, Marasa BS, Chen J, Turner DJ, Zhou H, Gorospe M, Wang JY.

Mol Biol Cell. 2007 Nov;18(11):4579-90. Epub 2007 Sep 5.


TLR4 mediates MAPK-STAT3 axis activation in bladder epithelial cells.

Ying H, Da L, Yu-xiu S, Yu X, Li-xia L, Li-mei X, Wei-dong R.

Inflammation. 2013 Oct;36(5):1064-74. doi: 10.1007/s10753-013-9638-7.


[The effect of lipopolysaccharide on gene expression of TLR4 and MD-2 in rat alveolar macrophage and its secretion of inflammation cytokines].

Ren WY, Zhu L, Hua F, Jin JJ, Cai YY.

Zhonghua Jie He He Hu Xi Za Zhi. 2010 May;33(5):367-71. Chinese.


Chronic estradiol administration in vivo promotes the proinflammatory response of macrophages to TLR4 activation: involvement of the phosphatidylinositol 3-kinase pathway.

Calippe B, Douin-Echinard V, Laffargue M, Laurell H, Rana-Poussine V, Pipy B, Guéry JC, Bayard F, Arnal JF, Gourdy P.

J Immunol. 2008 Jun 15;180(12):7980-8.

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