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Results: 1 to 20 of 99

1.

Ethanol self-administration and nicotine treatment increase brain levels of CYP2D in African green monkeys.

Miller RT, Miksys S, Hoffmann E, Tyndale RF.

Br J Pharmacol. 2014 Jun;171(12):3077-88. doi: 10.1111/bph.12652.

PMID:
24611668
[PubMed - in process]
2.

Induction of the drug metabolizing enzyme CYP2D in monkey brain by chronic nicotine treatment.

Mann A, Miksys S, Lee A, Mash DC, Tyndale RF.

Neuropharmacology. 2008 Dec;55(7):1147-55. doi: 10.1016/j.neuropharm.2008.07.017. Epub 2008 Jul 19.

PMID:
18687346
[PubMed - indexed for MEDLINE]
3.

Chronic nicotine treatment induces rat CYP2D in the brain but not in the liver: an investigation of induction and time course.

Yue J, Miksys S, Hoffmann E, Tyndale RF.

J Psychiatry Neurosci. 2008 Jan;33(1):54-63.

PMID:
18197273
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Ethanol self-administration and nicotine treatment induce brain levels of CYP2B6 and CYP2E1 in African green monkeys.

Ferguson CS, Miksys S, Palmour RM, Tyndale RF.

Neuropharmacology. 2013 Sep;72:74-81. doi: 10.1016/j.neuropharm.2013.04.022. Epub 2013 Apr 29.

PMID:
23639433
[PubMed - indexed for MEDLINE]
5.

Independent and combined effects of ethanol self-administration and nicotine treatment on hepatic CYP2E1 in African green monkeys.

Ferguson CS, Miksys S, Palmour R, Tyndale RF.

Drug Metab Dispos. 2011 Dec;39(12):2233-41. doi: 10.1124/dmd.111.040378. Epub 2011 Aug 25.

PMID:
21868470
[PubMed - indexed for MEDLINE]
Free Article
6.

Differential effects of nicotine treatment and ethanol self-administration on CYP2A6, CYP2B6 and nicotine pharmacokinetics in African green monkeys.

Ferguson CS, Miksys S, Palmour RM, Tyndale RF.

J Pharmacol Exp Ther. 2012 Dec;343(3):628-37. doi: 10.1124/jpet.112.198564. Epub 2012 Aug 30.

PMID:
22935730
[PubMed - indexed for MEDLINE]
Free Article
7.

Regional and cellular distribution of CYP2E1 in monkey brain and its induction by chronic nicotine.

Joshi M, Tyndale RF.

Neuropharmacology. 2006 Apr;50(5):568-75. Epub 2005 Dec 20.

PMID:
16368115
[PubMed - indexed for MEDLINE]
8.

Induction and recovery time course of rat brain CYP2E1 after nicotine treatment.

Joshi M, Tyndale RF.

Drug Metab Dispos. 2006 Apr;34(4):647-52. Epub 2006 Jan 24.

PMID:
16434548
[PubMed - indexed for MEDLINE]
Free Article
9.

Phenobarbital increases monkey in vivo nicotine disposition and induces liver and brain CYP2B6 protein.

Lee AM, Miksys S, Tyndale RF.

Br J Pharmacol. 2006 Jul;148(6):786-94. Epub 2006 Jun 5.

PMID:
16751792
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Brain CYP2E1 is induced by nicotine and ethanol in rat and is higher in smokers and alcoholics.

Howard LA, Miksys S, Hoffmann E, Mash D, Tyndale RF.

Br J Pharmacol. 2003 Apr;138(7):1376-86.

PMID:
12711639
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Differential induction of ethanol-metabolizing CYP2E1 and nicotine-metabolizing CYP2B1/2 in rat liver by chronic nicotine treatment and voluntary ethanol intake.

Yue J, Khokhar J, Miksys S, Tyndale RF.

Eur J Pharmacol. 2009 May 1;609(1-3):88-95. doi: 10.1016/j.ejphar.2009.03.015. Epub 2009 Mar 13.

PMID:
19285975
[PubMed - indexed for MEDLINE]
12.

CYP2B6 is expressed in African Green monkey brain and is induced by chronic nicotine treatment.

Lee AM, Miksys S, Palmour R, Tyndale RF.

Neuropharmacology. 2006 Mar;50(4):441-50. Epub 2005 Nov 23.

PMID:
16309716
[PubMed - indexed for MEDLINE]
13.

Regional and cellular distribution of CYP2D subfamily members in rat brain.

Miksys S, Rao Y, Sellers EM, Kwan M, Mendis D, Tyndale RF.

Xenobiotica. 2000 Jun;30(6):547-64.

PMID:
10923858
[PubMed - indexed for MEDLINE]
14.

Rat brain CYP2B induction by nicotine is persistent and does not involve nicotinic acetylcholine receptors.

Khokhar JY, Miksys SL, Tyndale RF.

Brain Res. 2010 Aug 12;1348:1-9. doi: 10.1016/j.brainres.2010.06.035. Epub 2010 Jun 20.

PMID:
20599831
[PubMed - indexed for MEDLINE]
15.

Induction of CYP2B1/2 and nicotine metabolism by ethanol in rat liver but not rat brain.

Schoedel KA, Sellers EM, Tyndale RF.

Biochem Pharmacol. 2001 Oct 15;62(8):1025-36.

PMID:
11597571
[PubMed - indexed for MEDLINE]
16.

Low doses of nicotine and ethanol induce CYP2E1 and chlorzoxazone metabolism in rat liver.

Howard LA, Micu AL, Sellers EM, Tyndale RF.

J Pharmacol Exp Ther. 2001 Nov;299(2):542-50.

PMID:
11602665
[PubMed - indexed for MEDLINE]
Free Article
17.

In vivo and in vitro characterization of chlorzoxazone metabolism and hepatic CYP2E1 levels in African Green monkeys: induction by chronic nicotine treatment.

Lee AM, Yue J, Tyndale RF.

Drug Metab Dispos. 2006 Sep;34(9):1508-15. Epub 2006 Jun 8.

PMID:
16763012
[PubMed - indexed for MEDLINE]
Free Article
18.

Regional and cellular expression of CYP2D6 in human brain: higher levels in alcoholics.

Miksys S, Rao Y, Hoffmann E, Mash DC, Tyndale RF.

J Neurochem. 2002 Sep;82(6):1376-87.

PMID:
12354285
[PubMed - indexed for MEDLINE]
19.

Human CYP2D6 and mouse CYP2Ds: organ distribution in a humanized mouse model.

Miksys SL, Cheung C, Gonzalez FJ, Tyndale RF.

Drug Metab Dispos. 2005 Oct;33(10):1495-502. Epub 2005 Jul 20.

PMID:
16033950
[PubMed - indexed for MEDLINE]
Free Article
20.

Disruptions in serotonergic regulation of cortical glutamate release in primate insular cortex in response to chronic ethanol and nursery rearing.

Alexander GM, Graef JD, Hammarback JA, Nordskog BK, Burnett EJ, Daunais JB, Bennett AJ, Friedman DP, Suomi SJ, Godwin DW.

Neuroscience. 2012 Apr 5;207:167-81. doi: 10.1016/j.neuroscience.2012.01.027. Epub 2012 Jan 21.

PMID:
22305886
[PubMed - indexed for MEDLINE]

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