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Items: 1 to 20 of 149


PPARδ deficiency disrupts hypoxia-mediated tumorigenic potential of colon cancer cells.

Jeong E, Koo JE, Yeon SH, Kwak MK, Hwang DH, Lee JY.

Mol Carcinog. 2014 Nov;53(11):926-37. doi: 10.1002/mc.22144. Epub 2014 Mar 9.


Caffeine inhibits adenosine-induced accumulation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and interleukin-8 expression in hypoxic human colon cancer cells.

Merighi S, Benini A, Mirandola P, Gessi S, Varani K, Simioni C, Leung E, Maclennan S, Baraldi PG, Borea PA.

Mol Pharmacol. 2007 Aug;72(2):395-406. Epub 2007 May 8.


The PPARδ ligand L-165041 inhibits VEGF-induced angiogenesis, but the antiangiogenic effect is not related to PPARδ.

Park JH, Lee KS, Lim HJ, Kim H, Kwak HJ, Park HY.

J Cell Biochem. 2012 Jun;113(6):1947-54. doi: 10.1002/jcb.24063.


Suppression of VEGF expression through interruption of the HIF‑1α and Akt signaling cascade modulates the anti‑angiogenic activity of DAPK in ovarian carcinoma cells.

Park ST, Kim BR, Park SH, Lee JH, Lee EJ, Lee SH, Rho SB.

Oncol Rep. 2014 Feb;31(2):1021-9. doi: 10.3892/or.2013.2928. Epub 2013 Dec 16.


Topotecan inhibits vascular endothelial growth factor production and angiogenic activity induced by hypoxia in human neuroblastoma by targeting hypoxia-inducible factor-1alpha and -2alpha.

Puppo M, Battaglia F, Ottaviano C, Delfino S, Ribatti D, Varesio L, Bosco MC.

Mol Cancer Ther. 2008 Jul;7(7):1974-84. doi: 10.1158/1535-7163.MCT-07-2059.


Interleukin-1 Receptor Type 2 Acts with c-Fos to Enhance the Expression of Interleukin-6 and Vascular Endothelial Growth Factor A in Colon Cancer Cells and Induce Angiogenesis.

Mar AC, Chu CH, Lee HJ, Chien CW, Cheng JJ, Yang SH, Jiang JK, Lee TC.

J Biol Chem. 2015 Sep 4;290(36):22212-24. doi: 10.1074/jbc.M115.644823. Epub 2015 Jul 24.


Hypoxia triggers a Nur77-β-catenin feed-forward loop to promote the invasive growth of colon cancer cells.

To SK, Zeng WJ, Zeng JZ, Wong AS.

Br J Cancer. 2014 Feb 18;110(4):935-45. doi: 10.1038/bjc.2013.816. Epub 2014 Jan 14.


Crosstalk between peroxisome proliferator-activated receptor delta and VEGF stimulates cancer progression.

Wang D, Wang H, Guo Y, Ning W, Katkuri S, Wahli W, Desvergne B, Dey SK, DuBois RN.

Proc Natl Acad Sci U S A. 2006 Dec 12;103(50):19069-74. Epub 2006 Dec 5.


A macrophage-dominant PI3K isoform controls hypoxia-induced HIF1α and HIF2α stability and tumor growth, angiogenesis, and metastasis.

Joshi S, Singh AR, Zulcic M, Durden DL.

Mol Cancer Res. 2014 Oct;12(10):1520-31. doi: 10.1158/1541-7786.MCR-13-0682. Epub 2014 Aug 7.


Modulation of transcription by the peroxisome proliferator-activated receptor delta--binding RNA aptamer in colon cancer cells.

Kwak H, Hwang I, Kim JH, Kim MY, Yang JS, Jeong S.

Mol Cancer Ther. 2009 Sep;8(9):2664-73. doi: 10.1158/1535-7163.MCT-09-0214. Epub 2009 Sep 1.


Magnolol suppresses hypoxia-induced angiogenesis via inhibition of HIF-1α/VEGF signaling pathway in human bladder cancer cells.

Chen MC, Lee CF, Huang WH, Chou TC.

Biochem Pharmacol. 2013 May 1;85(9):1278-87. doi: 10.1016/j.bcp.2013.02.009. Epub 2013 Feb 14.


PI3K/Akt contributes to increased expression of Toll-like receptor 4 in macrophages exposed to hypoxic stress.

Kim SY, Jeong E, Joung SM, Lee JY.

Biochem Biophys Res Commun. 2012 Mar 16;419(3):466-71. doi: 10.1016/j.bbrc.2012.02.015.


Ras homolog gene family, member A promotes p53 degradation and vascular endothelial growth factor-dependent angiogenesis through an interaction with murine double minute 2 under hypoxic conditions.

Ma J, Xue Y, Cui W, Li Y, Zhao Q, Ye W, Zheng J, Cheng Y, Ma Y, Li S, Han T, Miao L, Yao L, Zhang J, Liu W.

Cancer. 2012 Sep 1;118(17):4105-16. doi: 10.1002/cncr.27393. Epub 2012 Jan 3. Erratum in: Cancer. 2015 Feb 1;121(3):485.


Hypoxia-inducible factor-1-independent regulation of vascular endothelial growth factor by hypoxia in colon cancer.

Mizukami Y, Li J, Zhang X, Zimmer MA, Iliopoulos O, Chung DC.

Cancer Res. 2004 Mar 1;64(5):1765-72.


Hypoxia activates the K-ras proto-oncogene to stimulate angiogenesis and inhibit apoptosis in colon cancer cells.

Zeng M, Kikuchi H, Pino MS, Chung DC.

PLoS One. 2010 Jun 4;5(6):e10966. doi: 10.1371/journal.pone.0010966.


Induction of interleukin-8 preserves the angiogenic response in HIF-1alpha-deficient colon cancer cells.

Mizukami Y, Jo WS, Duerr EM, Gala M, Li J, Zhang X, Zimmer MA, Iliopoulos O, Zukerberg LR, Kohgo Y, Lynch MP, Rueda BR, Chung DC.

Nat Med. 2005 Sep;11(9):992-7. Epub 2005 Aug 28. Erratum in: Nat Med. 2006 Feb;12(2):253.


PTEN regulates angiogenesis through PI3K/Akt/VEGF signaling pathway in human pancreatic cancer cells.

Ma J, Sawai H, Ochi N, Matsuo Y, Xu D, Yasuda A, Takahashi H, Wakasugi T, Takeyama H.

Mol Cell Biochem. 2009 Nov;331(1-2):161-71. doi: 10.1007/s11010-009-0154-x. Epub 2009 May 13.


[Construction of a lentiviral vector of RNA interference against PPARS gene and the establishment of colon cancer cell line KM12C with stable knockdown of PPARdelta expression].

Jiang X, Yang L, Zhou Z, Li Y, Wang L, Yu Y, Wang C.

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2010 Apr;27(2):400-6. Chinese.

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