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Results: 1 to 20 of 89

1.

PTEN regulates BCRP/ABCG2 and the side population through the PI3K/Akt pathway in chronic myeloid leukemia.

Huang FF, Zhang L, Wu DS, Yuan XY, Chen FP, Zeng H, Yu YH, Zhao XL.

PLoS One. 2014 Mar 6;9(3):e88298. doi: 10.1371/journal.pone.0088298. eCollection 2014.

PMID:
24603487
[PubMed - in process]
Free PMC Article
2.

Inactivation of PTEN increases ABCG2 expression and the side population through the PI3K/Akt pathway in adult acute leukemia.

Huang FF, Wu DS, Zhang L, Yu YH, Yuan XY, Li WJ, Chen XP, Zhao XL, Chen FP, Zeng H.

Cancer Lett. 2013 Aug 9;336(1):96-105. doi: 10.1016/j.canlet.2013.04.006. Epub 2013 Apr 16.

PMID:
23603434
[PubMed - indexed for MEDLINE]
3.

Tyrosine kinase inhibitors influence ABCG2 expression in EGFR-positive MDCK BCRP cells via the PI3K/Akt signaling pathway.

Pick A, Wiese M.

ChemMedChem. 2012 Apr;7(4):650-62. doi: 10.1002/cmdc.201100543. Epub 2012 Feb 22.

PMID:
22354538
[PubMed - indexed for MEDLINE]
4.

Complex interaction of BCRP/ABCG2 and imatinib in BCR-ABL-expressing cells: BCRP-mediated resistance to imatinib is attenuated by imatinib-induced reduction of BCRP expression.

Nakanishi T, Shiozawa K, Hassel BA, Ross DD.

Blood. 2006 Jul 15;108(2):678-84. Epub 2006 Mar 16.

PMID:
16543472
[PubMed - indexed for MEDLINE]
Free Article
5.

Targeting the translational apparatus to improve leukemia therapy: roles of the PI3K/PTEN/Akt/mTOR pathway.

Martelli AM, Evangelisti C, Chappell W, Abrams SL, Bäsecke J, Stivala F, Donia M, Fagone P, Nicoletti F, Libra M, Ruvolo V, Ruvolo P, Kempf CR, Steelman LS, McCubrey JA.

Leukemia. 2011 Jul;25(7):1064-79. doi: 10.1038/leu.2011.46. Epub 2011 Mar 25. Review.

PMID:
21436840
[PubMed - indexed for MEDLINE]
6.

Versatile inhibitory effects of the flavonoid-derived PI3K/Akt inhibitor, LY294002, on ATP-binding cassette transporters that characterize stem cells.

Imai Y, Yamagishi H, Ono Y, Ueda Y.

Clin Transl Med. 2012 Oct 13;1(1):24. doi: 10.1186/2001-1326-1-24.

PMID:
23369170
[PubMed]
Free PMC Article
7.

Effect of phosphatase and tensin homology deleted on chromosome 10 (PTEN) gene transfection on reversal of multidrug resistance in K562/ADM cells.

Cheng Z, Yang N, Liang W, Yan X, Li L, Pan L.

Leuk Lymphoma. 2012 Jul;53(7):1383-9. doi: 10.3109/10428194.2011.650695. Epub 2012 Jan 31.

PMID:
22185283
[PubMed - indexed for MEDLINE]
8.

Inhibition of phosphoinositide-3 kinase pathway down regulates ABCG2 function and sensitizes malignant pleural mesothelioma to chemotherapy.

Fischer B, Frei C, Moura U, Stahel R, Felley-Bosco E.

Lung Cancer. 2012 Oct;78(1):23-9. doi: 10.1016/j.lungcan.2012.07.005. Epub 2012 Aug 1.

PMID:
22857894
[PubMed - indexed for MEDLINE]
9.

The PTEN/PI3K/Akt pathway regulates stem-like cells in primary esophageal carcinoma cells.

Li H, Gao Q, Guo L, Lu SH.

Cancer Biol Ther. 2011 Jun 1;11(11):950-8. Epub 2011 Jun 1.

PMID:
21467840
[PubMed - indexed for MEDLINE]
Free Article
10.

Roles of the RAF/MEK/ERK and PI3K/PTEN/AKT pathways in malignant transformation and drug resistance.

McCubrey JA, Steelman LS, Abrams SL, Lee JT, Chang F, Bertrand FE, Navolanic PM, Terrian DM, Franklin RA, D'Assoro AB, Salisbury JL, Mazzarino MC, Stivala F, Libra M.

Adv Enzyme Regul. 2006;46:249-79. Epub 2006 Jul 18.

PMID:
16854453
[PubMed - indexed for MEDLINE]
11.

PTEN's regulation of VEGF and VEGFR1 expression and its clinical significance in myeloid leukemia.

Zhiyong C, Wentong L, Xiaoyang Y, Ling P.

Med Oncol. 2012 Jun;29(2):1084-92. doi: 10.1007/s12032-011-9867-2. Epub 2011 Mar 1.

PMID:
21360018
[PubMed - indexed for MEDLINE]
12.

Comparison of ATP-binding cassette transporter interactions with the tyrosine kinase inhibitors imatinib, nilotinib, and dasatinib.

Dohse M, Scharenberg C, Shukla S, Robey RW, Volkmann T, Deeken JF, Brendel C, Ambudkar SV, Neubauer A, Bates SE.

Drug Metab Dispos. 2010 Aug;38(8):1371-80. doi: 10.1124/dmd.109.031302. Epub 2010 Apr 27.

PMID:
20423956
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Molecular aspects of gefitinib antiproliferative and pro-apoptotic effects in PTEN-positive and PTEN-negative prostate cancer cell lines.

Festuccia C, Muzi P, Millimaggi D, Biordi L, Gravina GL, Speca S, Angelucci A, Dolo V, Vicentini C, Bologna M.

Endocr Relat Cancer. 2005 Dec;12(4):983-98.

PMID:
16322337
[PubMed - indexed for MEDLINE]
Free Article
14.

The PI3K/Akt inhibitor LY294002 reverses BCRP-mediated drug resistance without affecting BCRP translocation.

Imai Y, Yoshimori M, Fukuda K, Yamagishi H, Ueda Y.

Oncol Rep. 2012 Jun;27(6):1703-9. doi: 10.3892/or.2012.1724. Epub 2012 Mar 15.

PMID:
22426819
[PubMed - indexed for MEDLINE]
15.

Hypoxia influences stem cell-like properties in multidrug resistant K562 leukemic cells.

Cui XY, Skretting G, Jing Y, Sun H, Sandset PM, Sun L.

Blood Cells Mol Dis. 2013 Oct;51(3):177-84. doi: 10.1016/j.bcmd.2013.05.003. Epub 2013 May 29.

PMID:
23725749
[PubMed - indexed for MEDLINE]
16.

Long-term exposure of leukemia cells to multi-targeted tyrosine kinase inhibitor induces activations of AKT, ERK and STAT5 signaling via epigenetic silencing of the PTEN gene.

Nishioka C, Ikezoe T, Yang J, Yokoyama A.

Leukemia. 2010 Sep;24(9):1631-40. doi: 10.1038/leu.2010.145. Epub 2010 Jul 1.

PMID:
20596030
[PubMed - indexed for MEDLINE]
17.

Activation of PI3K/Akt/mTOR signaling pathway triggered by PTEN downregulation in the pathogenesis of Crohn's disease.

Long SH, He Y, Chen MH, Cao K, Chen YJ, Chen BL, Mao R, Zhang SH, Zhu ZH, Zeng ZR, Hu PJ.

J Dig Dis. 2013 Dec;14(12):662-9. doi: 10.1111/1751-2980.12095.

PMID:
23962154
[PubMed - in process]
18.

Upregulation of PTEN in glioma cells by cord blood mesenchymal stem cells inhibits migration via downregulation of the PI3K/Akt pathway.

Dasari VR, Kaur K, Velpula KK, Gujrati M, Fassett D, Klopfenstein JD, Dinh DH, Rao JS.

PLoS One. 2010 Apr 26;5(4):e10350. doi: 10.1371/journal.pone.0010350.

PMID:
20436671
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Evi1 represses PTEN expression and activates PI3K/AKT/mTOR via interactions with polycomb proteins.

Yoshimi A, Goyama S, Watanabe-Okochi N, Yoshiki Y, Nannya Y, Nitta E, Arai S, Sato T, Shimabe M, Nakagawa M, Imai Y, Kitamura T, Kurokawa M.

Blood. 2011 Mar 31;117(13):3617-28. doi: 10.1182/blood-2009-12-261602. Epub 2011 Feb 2.

PMID:
21289308
[PubMed - indexed for MEDLINE]
Free Article
20.

Imatinib-mediated inactivation of Akt regulates ABCG2 function in head and neck squamous cell carcinoma.

Chu TS, Chen JS, Lopez JP, Pardo FS, Aguilera J, Ongkeko WM.

Arch Otolaryngol Head Neck Surg. 2008 Sep;134(9):979-84. doi: 10.1001/archotol.134.9.979.

PMID:
18794444
[PubMed - indexed for MEDLINE]

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