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Innate DNA sensing is impaired in HIV patients and IFI16 expression correlates with chronic immune activation.

Nissen SK, Højen JF, Andersen KL, Kofod-Olsen E, Berg RK, Paludan SR, Østergaard L, Jakobsen MR, Tolstrup M, Mogensen TH.

Clin Exp Immunol. 2014 Jul;177(1):295-309. doi: 10.1111/cei.12317.


Innate and adaptive immune responses both contribute to pathological CD4 T cell activation in HIV-1 infected Ugandans.

Eller MA, Blom KG, Gonzalez VD, Eller LA, Naluyima P, Laeyendecker O, Quinn TC, Kiwanuka N, Serwadda D, Sewankambo NK, Tasseneetrithep B, Wawer MJ, Gray RH, Marovich MA, Michael NL, de Souza MS, Wabwire-Mangen F, Robb ML, Currier JR, Sandberg JK.

PLoS One. 2011 Apr 19;6(4):e18779. doi: 10.1371/journal.pone.0018779.


Differential upregulation of CD38 on different T-cell subsets may influence the ability to reconstitute CD4+ T cells under successful highly active antiretroviral therapy.

Benito JM, López M, Lozano S, Ballesteros C, Martinez P, González-Lahoz J, Soriano V.

J Acquir Immune Defic Syndr. 2005 Apr 1;38(4):373-81.


Unmasking immune sensing of retroviruses: interplay between innate sensors and host effectors.

van Montfoort N, Olagnier D, Hiscott J.

Cytokine Growth Factor Rev. 2014 Dec;25(6):657-68. doi: 10.1016/j.cytogfr.2014.08.006. Epub 2014 Sep 3. Review.


Combined Env- and Gag-specific T cell responses in relation to programmed death-1 receptor and CD4 T cell loss rates in human immunodeficiency virus-1 infection.

Pettersen FO, Taskén K, Kvale D.

Clin Exp Immunol. 2010 Aug;161(2):315-23. doi: 10.1111/j.1365-2249.2010.04179.x. Epub 2010 May 10.


Immunological benefits of antiretroviral therapy in very early stages of asymptomatic chronic HIV-1 infection.

Plana M, García F, Gallart T, Tortajada C, Soriano A, Palou E, Maleno MJ, Barceló JJ, Vidal C, Cruceta A, Miró JM, Gatell JM.

AIDS. 2000 Sep 8;14(13):1921-33.


Dissociation of CD154 and cytokine expression patterns in CD38+ CD4+ memory T cells in chronic HIV-1 infection.

Espinosa E, Ormsby CE, Reyes-Terán G, Asaad R, Sieg SF, Lederman MM.

J Acquir Immune Defic Syndr. 2010 Dec;55(4):439-45. doi: 10.1097/QAI.0b013e3181ef991d.


T cells detect intracellular DNA but fail to induce type I IFN responses: implications for restriction of HIV replication.

Berg RK, Rahbek SH, Kofod-Olsen E, Holm CK, Melchjorsen J, Jensen DG, Hansen AL, Jørgensen LB, Ostergaard L, Tolstrup M, Larsen CS, Paludan SR, Jakobsen MR, Mogensen TH.

PLoS One. 2014 Jan 3;9(1):e84513. doi: 10.1371/journal.pone.0084513. eCollection 2014.


CD38+CD8+ T-cells negatively correlate with CD4 central memory cells in virally suppressed HIV-1-infected individuals.

Kolber MA.

AIDS. 2008 Oct 1;22(15):1937-41. doi: 10.1097/QAD.0b013e32830f97e2.


IFI16 DNA sensor is required for death of lymphoid CD4 T cells abortively infected with HIV.

Monroe KM, Yang Z, Johnson JR, Geng X, Doitsh G, Krogan NJ, Greene WC.

Science. 2014 Jan 24;343(6169):428-32. doi: 10.1126/science.1243640. Epub 2013 Dec 19.


A single HIV-1 cluster and a skewed immune homeostasis drive the early spread of HIV among resting CD4+ cell subsets within one month post-infection.

Bacchus C, Cheret A, Avettand-Fenoël V, Nembot G, Mélard A, Blanc C, Lascoux-Combe C, Slama L, Allegre T, Allavena C, Yazdanpanah Y, Duvivier C, Katlama C, Goujard C, Seksik BC, Leplatois A, Molina JM, Meyer L, Autran B, Rouzioux C; OPTIPRIM ANRS 147 study group.

PLoS One. 2013 May 14;8(5):e64219. doi: 10.1371/journal.pone.0064219. Print 2013.


Differential roles for the interferon-inducible IFI16 and AIM2 innate immune sensors for cytosolic DNA in cellular senescence of human fibroblasts.

Duan X, Ponomareva L, Veeranki S, Panchanathan R, Dickerson E, Choubey D.

Mol Cancer Res. 2011 May;9(5):589-602. doi: 10.1158/1541-7786.MCR-10-0565. Epub 2011 Apr 6.


HIV-1-infected children on HAART: immunologic features of three different levels of viral suppression.

Zaccarelli-Filho CA, Ono E, Machado DM, Brunialti M, Succi RC, Salomão R, Kallás EG, de Moraes-Pinto MI.

Cytometry B Clin Cytom. 2007 Jan 15;72(1):14-21.


Polymorphism in IFI16 affects CD4(+) T-cell counts in HIV-1 infection.

Booiman T, Kootstra NA.

Int J Immunogenet. 2014 Dec;41(6):518-20. doi: 10.1111/iji.12157. Epub 2014 Nov 3.


Disease Progression in HIV-1-Infected Viremic Controllers.

Groves KC, Bibby DF, Clark DA, Isaksen A, Deayton JR, Anderson J, Orkin C, Stagg AJ, McKnight A.

J Acquir Immune Defic Syndr. 2012 Dec 1;61(4):407-16. doi: 10.1097/QAI.0b013e318269c414.


Central memory CD4 cells are an early indicator of immune reconstitution in HIV/AIDS patients with anti-retroviral treatment.

Hua W, Jiao Y, Zhang H, Zhang T, Chen D, Zhang Y, Chen X, Wu H.

Immunol Invest. 2012;41(1):1-14. doi: 10.3109/08820139.2011.576739. Epub 2011 May 12.


Infection of CD127+ (interleukin-7 receptor+) CD4+ cells and overexpression of CTLA-4 are linked to loss of antigen-specific CD4 T cells during primary human immunodeficiency virus type 1 infection.

Zaunders JJ, Ip S, Munier ML, Kaufmann DE, Suzuki K, Brereton C, Sasson SC, Seddiki N, Koelsch K, Landay A, Grey P, Finlayson R, Kaldor J, Rosenberg ES, Walker BD, Fazekas de St Groth B, Cooper DA, Kelleher AD.

J Virol. 2006 Oct;80(20):10162-72.


Naïve and memory CD4+ T cells and T cell activation markers in HIV-1 infected children on HAART.

Resino S, Navarro J, Bellón JM, Gurbindo D, León JA, Muñoz-Fernández MA.

Clin Exp Immunol. 2001 Aug;125(2):266-73.


Close association of CD8+/CD38 bright with HIV-1 replication and complex relationship with CD4+ T-cell count.

Tuaillon E, Al Tabaa Y, Baillat V, Segondy M, Picot MC, Reynes J, Vendrell JP.

Cytometry B Clin Cytom. 2009 Jul;76(4):249-60. doi: 10.1002/cyto.b.20467.


Lack of correlation between the size of HIV proviral DNA reservoir and the level of immune activation in HIV-infected patients with a sustained undetectable HIV viral load for 10 years.

Poizot-Martin I, Faucher O, Obry-Roguet V, Nicolino-Brunet C, Ronot-Bregigeon S, Dignat-George F, Tamalet C.

J Clin Virol. 2013 Aug;57(4):351-5. doi: 10.1016/j.jcv.2013.04.007. Epub 2013 May 8.

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