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Results: 1 to 20 of 100

1.

Cathepsin C inhibitors: property optimization and identification of a clinical candidate.

Furber M, Tiden AK, Gardiner P, Mete A, Ford R, Millichip I, Stein L, Mather A, Kinchin E, Luckhurst C, Barber S, Cage P, Sanganee H, Austin R, Chohan K, Beri R, Thong B, Wallace A, Oreffo V, Hutchinson R, Harper S, Debreczeni J, Breed J, Wissler L, Edman K.

J Med Chem. 2014 Mar 27;57(6):2357-67. doi: 10.1021/jm401705g. Epub 2014 Mar 14.

PMID:
24592859
[PubMed - indexed for MEDLINE]
2.

Hydroxyethylene isostere inhibitors of human immunodeficiency virus-1 protease: structure-activity analysis using enzyme kinetics, X-ray crystallography, and infected T-cell assays.

Dreyer GB, Lambert DM, Meek TD, Carr TJ, Tomaszek TA Jr, Fernandez AV, Bartus H, Cacciavillani E, Hassell AM, Minnich M, et al.

Biochemistry. 1992 Jul 28;31(29):6646-59.

PMID:
1637805
[PubMed - indexed for MEDLINE]
3.

Pentapeptides containing two dehydrophenylalanine residues--synthesis, structural studies and evaluation of their activity towards cathepsin C.

Latajka R, Jewginski M, Makowski M, Pawełczak M, Huber T, Sewald N, Kafarski P.

J Pept Sci. 2008 Oct;14(10):1084-95. doi: 10.1002/psc.1045.

PMID:
18523964
[PubMed - indexed for MEDLINE]
4.

New non-hydroxamic ADAMTS-5 inhibitors based on the 1,2,4-triazole-3-thiol scaffold.

Maingot L, Leroux F, Landry V, Dumont J, Nagase H, Villoutreix B, Sperandio O, Deprez-Poulain R, Deprez B.

Bioorg Med Chem Lett. 2010 Nov 1;20(21):6213-6. doi: 10.1016/j.bmcl.2010.08.108. Epub 2010 Aug 27.

PMID:
20846863
[PubMed - indexed for MEDLINE]
5.

Identification of selective, nonpeptidic nitrile inhibitors of cathepsin s using the substrate activity screening method.

Patterson AW, Wood WJ, Hornsby M, Lesley S, Spraggon G, Ellman JA.

J Med Chem. 2006 Oct 19;49(21):6298-307.

PMID:
17034136
[PubMed - indexed for MEDLINE]
6.

Synthesis and activity of phosphinic tripeptide inhibitors of cathepsin C.

Mucha A, Paweł M, Hurek J, Kafarski P.

Bioorg Med Chem Lett. 2004 Jun 21;14(12):3113-6.

PMID:
15149655
[PubMed - indexed for MEDLINE]
7.

E-64c-hydrazide: a lead structure for the development of irreversible cathepsin C inhibitors.

Radzey H, Rethmeier M, Klimpel D, Grundhuber M, Sommerhoff CP, Schaschke N.

ChemMedChem. 2013 Aug;8(8):1314-21. doi: 10.1002/cmdc.201300093. Epub 2013 Jun 18.

PMID:
23780739
[PubMed - indexed for MEDLINE]
8.

Inhibitors of hepatitis C virus NS3.4A protease 1. Non-charged tetrapeptide variants.

Perni RB, Britt SD, Court JC, Courtney LF, Deininger DD, Farmer LJ, Gates CA, Harbeson SL, Kim JL, Landro JA, Levin RB, Luong YP, O'Malley ET, Pitlik J, Rao BG, Schairer WC, Thomson JA, Tung RD, Van Drie JH, Wei Y.

Bioorg Med Chem Lett. 2003 Nov 17;13(22):4059-63.

PMID:
14592508
[PubMed - indexed for MEDLINE]
9.

Novel route to the synthesis of peptides containing 2-amino-1'-hydroxymethyl ketones and their application as cathepsin K inhibitors.

Mendonca RV, Venkatraman S, Palmer JT.

Bioorg Med Chem Lett. 2002 Oct 21;12(20):2887-91.

PMID:
12270170
[PubMed - indexed for MEDLINE]
10.

Tetrahydroisoquinoline-3-carboxylate based matrix-metalloproteinase inhibitors: design, synthesis and structure-activity relationship.

Matter H, Schudok M, Schwab W, Thorwart W, Barbier D, Billen G, Haase B, Neises B, Weithmann K, Wollmann T.

Bioorg Med Chem. 2002 Nov;10(11):3529-44.

PMID:
12213468
[PubMed - indexed for MEDLINE]
11.

A new series of potent benzodiazepine gamma-secretase inhibitors.

Churcher I, Ashton K, Butcher JW, Clarke EE, Harrison T, Lewis HD, Owens AP, Teall MR, Williams S, Wrigley JD.

Bioorg Med Chem Lett. 2003 Jan 20;13(2):179-83.

PMID:
12482419
[PubMed - indexed for MEDLINE]
12.

Lead optimization of [(S)-gamma-(arylamino)prolyl]thiazolidine focused on gamma-substituent: Indoline compounds as potent DPP-IV inhibitors.

Sakashita H, Akahoshi F, Yoshida T, Kitajima H, Hayashi Y, Ishii S, Takashina Y, Tsutsumiuchi R, Ono S.

Bioorg Med Chem. 2007 Jan 15;15(2):641-55. Epub 2006 Nov 1.

PMID:
17113301
[PubMed - indexed for MEDLINE]
13.

Novel thiol-based TACE inhibitors. Part 2: Rational design, synthesis, and SAR of thiol-containing aryl sulfones.

Bandarage UK, Wang T, Come JH, Perola E, Wei Y, Rao BG.

Bioorg Med Chem Lett. 2008 Jan 1;18(1):44-8. Epub 2007 Nov 13.

PMID:
18054488
[PubMed - indexed for MEDLINE]
14.

Xanthine mimetics as potent dipeptidyl peptidase IV inhibitors.

Kurukulasuriya R, Rohde JJ, Szczepankiewicz BG, Basha F, Lai C, Jae HS, Winn M, Stewart KD, Longenecker KL, Lubben TW, Ballaron SJ, Sham HL, von Geldern TW.

Bioorg Med Chem Lett. 2006 Dec 15;16(24):6226-30. Epub 2006 Sep 28.

PMID:
17010607
[PubMed - indexed for MEDLINE]
15.

Challenges in modern drug discovery: a case study of boceprevir, an HCV protease inhibitor for the treatment of hepatitis C virus infection.

Njoroge FG, Chen KX, Shih NY, Piwinski JJ.

Acc Chem Res. 2008 Jan;41(1):50-9. doi: 10.1021/ar700109k. Review.

PMID:
18193821
[PubMed - indexed for MEDLINE]
16.

From model complexes to metalloprotein inhibition: a synergistic approach to structure-based drug discovery.

Puerta DT, Schames JR, Henchman RH, McCammon JA, Cohen SM.

Angew Chem Int Ed Engl. 2003 Aug 18;42(32):3772-4. No abstract available.

PMID:
12923840
[PubMed - indexed for MEDLINE]
17.

Arylaminoethyl carbamates as a novel series of potent and selective cathepsin S inhibitors.

Tully DC, Liu H, Chatterjee AK, Alper PB, Williams JA, Roberts MJ, Mutnick D, Woodmansee DH, Hollenbeck T, Gordon P, Chang J, Tuntland T, Tumanut C, Li J, Harris JL, Karanewsky DS.

Bioorg Med Chem Lett. 2006 Oct 1;16(19):5107-11. Epub 2006 Jul 28.

PMID:
16876407
[PubMed - indexed for MEDLINE]
18.

Synthesis, biological evaluation, and structure-activity relationships of potent noncovalent and nonpeptidic cruzain inhibitors as anti-Trypanosoma cruzi agents.

Ferreira RS, Dessoy MA, Pauli I, Souza ML, Krogh R, Sales AI, Oliva G, Dias LC, Andricopulo AD.

J Med Chem. 2014 Mar 27;57(6):2380-92. doi: 10.1021/jm401709b. Epub 2014 Mar 3.

PMID:
24533839
[PubMed - indexed for MEDLINE]
19.

Solid-phase analogue synthesis of caspase-3 inhibitors via palladium-catalyzed amination of 3-bromopyrazinones.

Isabel E, Aspiotis R, Black WC, Colucci J, Fortin R, Giroux A, Grimm EL, Han Y, Mellon C, Nicholson DW, Rasper DM, Renaud J, Roy S, Tam J, Tawa P, Vaillancourt JP, Xanthoudakis S, Zamboni RJ.

Bioorg Med Chem Lett. 2007 Mar 15;17(6):1671-4. Epub 2007 Jan 11.

PMID:
17251019
[PubMed - indexed for MEDLINE]
20.

Design and synthesis of conformationally-constrained MMP inhibitors.

Natchus MG, Cheng M, Wahl CT, Pikul S, Almstead NG, Bradley RS, Taiwo YO, Mieling GE, Dunaway CM, Snider CE, McIver JM, Barnett BL, McPhail SJ, Anastasio MB, De B.

Bioorg Med Chem Lett. 1998 Aug 18;8(16):2077-80.

PMID:
9873489
[PubMed - indexed for MEDLINE]

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