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Items: 1 to 20 of 94

1.

Structural basis for gating mechanisms of a eukaryotic P-glycoprotein homolog.

Kodan A, Yamaguchi T, Nakatsu T, Sakiyama K, Hipolito CJ, Fujioka A, Hirokane R, Ikeguchi K, Watanabe B, Hiratake J, Kimura Y, Suga H, Ueda K, Kato H.

Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4049-54. doi: 10.1073/pnas.1321562111. Epub 2014 Mar 3.

2.

Crystal structure of the multidrug transporter P-glycoprotein from Caenorhabditis elegans.

Jin MS, Oldham ML, Zhang Q, Chen J.

Nature. 2012 Oct 25;490(7421):566-9. doi: 10.1038/nature11448. Epub 2012 Sep 23.

3.

Repacking of the transmembrane domains of P-glycoprotein during the transport ATPase cycle.

Rosenberg MF, Velarde G, Ford RC, Martin C, Berridge G, Kerr ID, Callaghan R, Schmidlin A, Wooding C, Linton KJ, Higgins CF.

EMBO J. 2001 Oct 15;20(20):5615-25.

4.
5.

Three-dimensional structure of P-glycoprotein: the transmembrane regions adopt an asymmetric configuration in the nucleotide-bound state.

Rosenberg MF, Callaghan R, Modok S, Higgins CF, Ford RC.

J Biol Chem. 2005 Jan 28;280(4):2857-62. Epub 2004 Oct 13.

6.

Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain.

Ward AB, Szewczyk P, Grimard V, Lee CW, Martinez L, Doshi R, Caya A, Villaluz M, Pardon E, Cregger C, Swartz DJ, Falson PG, Urbatsch IL, Govaerts C, Steyaert J, Chang G.

Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13386-91. doi: 10.1073/pnas.1309275110. Epub 2013 Jul 30.

8.

Identification and characterization of functionally important elements in the multidrug resistance protein 1 COOH-terminal region.

Westlake CJ, Payen L, Gao M, Cole SP, Deeley RG.

J Biol Chem. 2004 Dec 17;279(51):53571-83. Epub 2004 Sep 30.

9.

P glycoprotein and the mechanism of multidrug resistance.

Váradi A, Szakács G, Bakos E, Sarkadi B.

Novartis Found Symp. 2002;243:54-65; discussion 65-8, 180-5. Review.

PMID:
11990782
10.

Human P-glycoprotein contains a greasy ball-and-socket joint at the second transmission interface.

Loo TW, Bartlett MC, Clarke DM.

J Biol Chem. 2013 Jul 12;288(28):20326-33. doi: 10.1074/jbc.M113.484550. Epub 2013 Jun 3.

11.

Thermodynamics of CFTR channel gating: a spreading conformational change initiates an irreversible gating cycle.

Csanády L, Nairn AC, Gadsby DC.

J Gen Physiol. 2006 Nov;128(5):523-33. Epub 2006 Oct 16.

12.

Structure of an ABC transporter in complex with its binding protein.

Hollenstein K, Frei DC, Locher KP.

Nature. 2007 Mar 8;446(7132):213-6. Epub 2007 Feb 25.

PMID:
17322901
13.

ATP hydrolysis-dependent multidrug efflux transporter: MDR1/P-glycoprotein.

Kimura Y, Matsuo M, Takahashi K, Saeki T, Kioka N, Amachi T, Ueda K.

Curr Drug Metab. 2004 Feb;5(1):1-10. Review.

PMID:
14965247
14.

3D cryo-electron reconstruction of BmrA, a bacterial multidrug ABC transporter in an inward-facing conformation and in a lipidic environment.

Fribourg PF, Chami M, Sorzano CO, Gubellini F, Marabini R, Marco S, Jault JM, Lévy D.

J Mol Biol. 2014 May 15;426(10):2059-69. doi: 10.1016/j.jmb.2014.03.002. Epub 2014 Mar 11.

PMID:
24630999
15.

Structure and mechanism of ABC transporter proteins.

Hollenstein K, Dawson RJ, Locher KP.

Curr Opin Struct Biol. 2007 Aug;17(4):412-8. Epub 2007 Aug 27. Review.

PMID:
17723295
16.

Data-driven homology modelling of P-glycoprotein in the ATP-bound state indicates flexibility of the transmembrane domains.

Stockner T, de Vries SJ, Bonvin AM, Ecker GF, Chiba P.

FEBS J. 2009 Feb;276(4):964-72. doi: 10.1111/j.1742-4658.2008.06832.x.

17.

[ATP hydrolysis-driven gating of an ABC transporter CFTR channel: from stills to movies].

Sohma Y, Yamashita H.

Nihon Yakurigaku Zasshi. 2013 May;141(5):230-4. Review. Japanese. No abstract available.

PMID:
23665551
18.

Structure-based interpretation of the mutagenesis database for the nucleotide binding domains of P-glycoprotein.

Lawson J, O'Mara ML, Kerr ID.

Biochim Biophys Acta. 2008 Feb;1778(2):376-91. Epub 2007 Nov 1. Review.

19.
20.

Do drug substrates enter the common drug-binding pocket of P-glycoprotein through "gates"?

Loo TW, Clarke DM.

Biochem Biophys Res Commun. 2005 Apr 8;329(2):419-22.

PMID:
15737603
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