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Results: 1 to 20 of 216

1.

Fibroblast growth factor 21 protects against acetaminophen-induced hepatotoxicity by potentiating peroxisome proliferator-activated receptor coactivator protein-1α-mediated antioxidant capacity in mice.

Ye D, Wang Y, Li H, Jia W, Man K, Lo CM, Wang Y, Lam KS, Xu A.

Hepatology. 2014 Sep;60(3):977-89. doi: 10.1002/hep.27060. Epub 2014 Jul 25.

PMID:
24590984
[PubMed - indexed for MEDLINE]
2.

CHOP is a critical regulator of acetaminophen-induced hepatotoxicity.

Uzi D, Barda L, Scaiewicz V, Mills M, Mueller T, Gonzalez-Rodriguez A, Valverde AM, Iwawaki T, Nahmias Y, Xavier R, Chung RT, Tirosh B, Shibolet O.

J Hepatol. 2013 Sep;59(3):495-503. doi: 10.1016/j.jhep.2013.04.024. Epub 2013 May 9.

PMID:
23665281
[PubMed - indexed for MEDLINE]
3.

Protein tyrosine phosphatase 1B modulates GSK3β/Nrf2 and IGFIR signaling pathways in acetaminophen-induced hepatotoxicity.

Mobasher MA, González-Rodriguez A, Santamaría B, Ramos S, Martín MÁ, Goya L, Rada P, Letzig L, James LP, Cuadrado A, Martín-Pérez J, Simpson KJ, Muntané J, Valverde AM.

Cell Death Dis. 2013 May 9;4:e626. doi: 10.1038/cddis.2013.150.

PMID:
23661004
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Distinct roles of NF-kappaB p50 in the regulation of acetaminophen-induced inflammatory mediator production and hepatotoxicity.

Dambach DM, Durham SK, Laskin JD, Laskin DL.

Toxicol Appl Pharmacol. 2006 Mar 1;211(2):157-65. Epub 2005 Aug 2.

PMID:
16081117
[PubMed - indexed for MEDLINE]
5.

Rifampicin-activated human pregnane X receptor and CYP3A4 induction enhance acetaminophen-induced toxicity.

Cheng J, Ma X, Krausz KW, Idle JR, Gonzalez FJ.

Drug Metab Dispos. 2009 Aug;37(8):1611-21. doi: 10.1124/dmd.109.027565. Epub 2009 May 21.

PMID:
19460945
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Protective effects of salidroside against acetaminophen-induced toxicity in mice.

Wu YL, Piao DM, Han XH, Nan JX.

Biol Pharm Bull. 2008 Aug;31(8):1523-9.

PMID:
18670083
[PubMed - indexed for MEDLINE]
Free Article
7.

The role of hypoxia-inducible factor-1α in acetaminophen hepatotoxicity.

Sparkenbaugh EM, Saini Y, Greenwood KK, LaPres JJ, Luyendyk JP, Copple BL, Maddox JF, Ganey PE, Roth RA.

J Pharmacol Exp Ther. 2011 Aug;338(2):492-502. doi: 10.1124/jpet.111.180521. Epub 2011 May 16.

PMID:
21576378
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Peroxisome proliferator-activated receptor alpha induction of uncoupling protein 2 protects against acetaminophen-induced liver toxicity.

Patterson AD, Shah YM, Matsubara T, Krausz KW, Gonzalez FJ.

Hepatology. 2012 Jul;56(1):281-90. doi: 10.1002/hep.25645. Epub 2012 Jun 6.

PMID:
22318764
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Acetaminophen-induced hepatotoxicity and protein nitration in neuronal nitric-oxide synthase knockout mice.

Agarwal R, Hennings L, Rafferty TM, Letzig LG, McCullough S, James LP, MacMillan-Crow LA, Hinson JA.

J Pharmacol Exp Ther. 2012 Jan;340(1):134-42. doi: 10.1124/jpet.111.184192. Epub 2011 Oct 14.

PMID:
22001257
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Nrf2-mediated liver protection by sauchinone, an antioxidant lignan, from acetaminophen toxicity through the PKCδ-GSK3β pathway.

Kay HY, Kim YW, Ryu da H, Sung SH, Hwang SJ, Kim SG.

Br J Pharmacol. 2011 Aug;163(8):1653-65. doi: 10.1111/j.1476-5381.2010.01095.x.

PMID:
21039417
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes.

Enomoto A, Itoh K, Nagayoshi E, Haruta J, Kimura T, O'Connor T, Harada T, Yamamoto M.

Toxicol Sci. 2001 Jan;59(1):169-77.

PMID:
11134556
[PubMed - indexed for MEDLINE]
Free Article
12.

Aldo-keto reductase-7A protects liver cells and tissues from acetaminophen-induced oxidative stress and hepatotoxicity.

Ahmed MM, Wang T, Luo Y, Ye S, Wu Q, Guo Z, Roebuck BD, Sutter TR, Yang JY.

Hepatology. 2011 Oct;54(4):1322-32. doi: 10.1002/hep.24493. Epub 2011 Sep 6.

PMID:
21688283
[PubMed - indexed for MEDLINE]
13.

Protective effects of 2,4-dihydroxybenzophenone against acetaminophen-induced hepatotoxicity in mice.

He YY, Zhang BX, Jia FL.

World J Gastroenterol. 2011 Jun 7;17(21):2663-6. doi: 10.3748/wjg.v17.i21.2663.

PMID:
21677837
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Disruption of thioredoxin reductase 1 protects mice from acute acetaminophen-induced hepatotoxicity through enhanced NRF2 activity.

Patterson AD, Carlson BA, Li F, Bonzo JA, Yoo MH, Krausz KW, Conrad M, Chen C, Gonzalez FJ, Hatfield DL.

Chem Res Toxicol. 2013 Jul 15;26(7):1088-96. doi: 10.1021/tx4001013. Epub 2013 Jun 7.

PMID:
23697945
[PubMed - indexed for MEDLINE]
15.

Novel protective mechanisms for S-adenosyl-L-methionine against acetaminophen hepatotoxicity: improvement of key antioxidant enzymatic function.

Michael Brown J, Ball JG, Wright MS, Van Meter S, Valentovic MA.

Toxicol Lett. 2012 Aug 3;212(3):320-8. doi: 10.1016/j.toxlet.2012.05.018. Epub 2012 Jun 5.

PMID:
22683606
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Secretory phospholipase A₂-mediated progression of hepatotoxicity initiated by acetaminophen is exacerbated in the absence of hepatic COX-2.

Bhave VS, Donthamsetty S, Latendresse JR, Cunningham ML, Mehendale HM.

Toxicol Appl Pharmacol. 2011 Mar 15;251(3):173-80. doi: 10.1016/j.taap.2011.01.013. Epub 2011 Jan 26.

PMID:
21277885
[PubMed - indexed for MEDLINE]
17.

Hepatoprotective role of endogenous interleukin-13 in a murine model of acetaminophen-induced liver disease.

Yee SB, Bourdi M, Masson MJ, Pohl LR.

Chem Res Toxicol. 2007 May;20(5):734-44. Epub 2007 Apr 18.

PMID:
17439248
[PubMed - indexed for MEDLINE]
18.

Role of galectin-3 in acetaminophen-induced hepatotoxicity and inflammatory mediator production.

Dragomir AC, Sun R, Mishin V, Hall LB, Laskin JD, Laskin DL.

Toxicol Sci. 2012 Jun;127(2):609-19. doi: 10.1093/toxsci/kfs117. Epub 2012 Mar 29.

PMID:
22461450
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

The PPAR activator docosahexaenoic acid prevents acetaminophen hepatotoxicity in male CD-1 mice.

Nguyen KA, Carbone JM, Silva VM, Chen C, Hennig GE, Whiteley HE, Manautou JE.

J Toxicol Environ Health A. 1999 Oct 15;58(3):171-86.

PMID:
10522648
[PubMed - indexed for MEDLINE]
20.

Differential Fmo3 gene expression in various liver injury models involving hepatic oxidative stress in mice.

Rudraiah S, Moscovitz JE, Donepudi AC, Campion SN, Slitt AL, Aleksunes LM, Manautou JE.

Toxicology. 2014 Nov 5;325:85-95. doi: 10.1016/j.tox.2014.08.013. Epub 2014 Sep 2.

PMID:
25193093
[PubMed - indexed for MEDLINE]
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