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NLRP6 inflammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion.

Wlodarska M, Thaiss CA, Nowarski R, Henao-Mejia J, Zhang JP, Brown EM, Frankel G, Levy M, Katz MN, Philbrick WM, Elinav E, Finlay BB, Flavell RA.

Cell. 2014 Feb 27;156(5):1045-59. doi: 10.1016/j.cell.2014.01.026.


Mucus, it is not just a static barrier.

Chen GY, Stappenbeck TS.

Sci Signal. 2014 Apr 29;7(323):pe11. doi: 10.1126/scisignal.2005357.


Is the intestinal goblet cell a major immune cell?

Johansson ME, Hansson GC.

Cell Host Microbe. 2014 Mar 12;15(3):251-2. doi: 10.1016/j.chom.2014.02.014.


A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion.

Birchenough GM, Nyström EE, Johansson ME, Hansson GC.

Science. 2016 Jun 24;352(6293):1535-42. doi: 10.1126/science.aaf7419.


Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling.

Levy M, Thaiss CA, Zeevi D, Dohnalová L, Zilberman-Schapira G, Mahdi JA, David E, Savidor A, Korem T, Herzig Y, Pevsner-Fischer M, Shapiro H, Christ A, Harmelin A, Halpern Z, Latz E, Flavell RA, Amit I, Segal E, Elinav E.

Cell. 2015 Dec 3;163(6):1428-43. doi: 10.1016/j.cell.2015.10.048.


Microbial modulation of innate defense: goblet cells and the intestinal mucus layer.

Deplancke B, Gaskins HR.

Am J Clin Nutr. 2001 Jun;73(6):1131S-1141S. Review.


NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis.

Elinav E, Strowig T, Kau AL, Henao-Mejia J, Thaiss CA, Booth CJ, Peaper DR, Bertin J, Eisenbarth SC, Gordon JI, Flavell RA.

Cell. 2011 May 27;145(5):745-57. doi: 10.1016/j.cell.2011.04.022. Epub 2011 May 12.


Intestinal epithelium-specific MyD88 signaling impacts host susceptibility to infectious colitis by promoting protective goblet cell and antimicrobial responses.

Bhinder G, Stahl M, Sham HP, Crowley SM, Morampudi V, Dalwadi U, Ma C, Jacobson K, Vallance BA.

Infect Immun. 2014 Sep;82(9):3753-63. doi: 10.1128/IAI.02045-14. Epub 2014 Jun 23.


Bacteroides thetaiotaomicron and Faecalibacterium prausnitzii influence the production of mucus glycans and the development of goblet cells in the colonic epithelium of a gnotobiotic model rodent.

Wrzosek L, Miquel S, Noordine ML, Bouet S, Joncquel Chevalier-Curt M, Robert V, Philippe C, Bridonneau C, Cherbuy C, Robbe-Masselot C, Langella P, Thomas M.

BMC Biol. 2013 May 21;11:61. doi: 10.1186/1741-7007-11-61.


γδ T-cell-deficient mice show alterations in mucin expression, glycosylation, and goblet cells but maintain an intact mucus layer.

Kober OI, Ahl D, Pin C, Holm L, Carding SR, Juge N.

Am J Physiol Gastrointest Liver Physiol. 2014 Apr 1;306(7):G582-93. doi: 10.1152/ajpgi.00218.2013. Epub 2014 Feb 6.


Intestinal goblet cells and mucins in health and disease: recent insights and progress.

Kim YS, Ho SB.

Curr Gastroenterol Rep. 2010 Oct;12(5):319-30. doi: 10.1007/s11894-010-0131-2. Review.


Muc2 protects against lethal infectious colitis by disassociating pathogenic and commensal bacteria from the colonic mucosa.

Bergstrom KS, Kissoon-Singh V, Gibson DL, Ma C, Montero M, Sham HP, Ryz N, Huang T, Velcich A, Finlay BB, Chadee K, Vallance BA.

PLoS Pathog. 2010 May 13;6(5):e1000902. doi: 10.1371/journal.ppat.1000902.


New developments in goblet cell mucus secretion and function.

Birchenough GM, Johansson ME, Gustafsson JK, Bergström JH, Hansson GC.

Mucosal Immunol. 2015 Jul;8(4):712-9. doi: 10.1038/mi.2015.32. Epub 2015 Apr 15. Review.


Autophagy proteins control goblet cell function by potentiating reactive oxygen species production.

Patel KK, Miyoshi H, Beatty WL, Head RD, Malvin NP, Cadwell K, Guan JL, Saitoh T, Akira S, Seglen PO, Dinauer MC, Virgin HW, Stappenbeck TS.

EMBO J. 2013 Dec 11;32(24):3130-44. doi: 10.1038/emboj.2013.233. Epub 2013 Nov 1.


The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria.

Johansson ME, Phillipson M, Petersson J, Velcich A, Holm L, Hansson GC.

Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):15064-9. doi: 10.1073/pnas.0803124105. Epub 2008 Sep 19.


Inflammasomes of the intestinal epithelium.

Sellin ME, Maslowski KM, Maloy KJ, Hardt WD.

Trends Immunol. 2015 Aug;36(8):442-50. doi: 10.1016/ Epub 2015 Jul 9. Review.


Microbial sensing by goblet cells controls immune surveillance of luminal antigens in the colon.

Knoop KA, McDonald KG, McCrate S, McDole JR, Newberry RD.

Mucosal Immunol. 2015 Jan;8(1):198-210. doi: 10.1038/mi.2014.58. Epub 2014 Jul 9.


CD4+ T cells drive goblet cell depletion during Citrobacter rodentium infection.

Chan JM, Bhinder G, Sham HP, Ryz N, Huang T, Bergstrom KS, Vallance BA.

Infect Immun. 2013 Dec;81(12):4649-58. doi: 10.1128/IAI.00655-13. Epub 2013 Oct 7.


Goblet cell compound exocytosis in the defense against bacterial invasion in the colon exposed to ischemia-reperfusion.

Grootjans J, Hundscheid IH, Buurman WA.

Gut Microbes. 2013 May-Jun;4(3):232-5. doi: 10.4161/gmic.23866. Epub 2013 Mar 31. Review.


Mucus and adiponectin deficiency: role in chronic inflammation-induced colon cancer.

Saxena A, Baliga MS, Ponemone V, Kaur K, Larsen B, Fletcher E, Greene J, Fayad R.

Int J Colorectal Dis. 2013 Sep;28(9):1267-79. doi: 10.1007/s00384-013-1664-2. Epub 2013 Mar 9.

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