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Results: 1 to 20 of 98

1.

Role of the SIK2-p35-PJA2 complex in pancreatic β-cell functional compensation.

Sakamaki J, Fu A, Reeks C, Baird S, Depatie C, Al Azzabi M, Bardeesy N, Gingras AC, Yee SP, Screaton RA.

Nat Cell Biol. 2014 Mar;16(3):234-44. doi: 10.1038/ncb2919. Erratum in: Nat Cell Biol. 2014 Apr;16(4):382.

PMID:
24561619
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

SIK2 regulates insulin secretion.

Belgardt BF, Stoffel M.

Nat Cell Biol. 2014 Mar;16(3):210-2. doi: 10.1038/ncb2925.

PMID:
24576898
[PubMed - indexed for MEDLINE]
3.

Loss of AMP-activated protein kinase alpha2 subunit in mouse beta-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia.

Beall C, Piipari K, Al-Qassab H, Smith MA, Parker N, Carling D, Viollet B, Withers DJ, Ashford ML.

Biochem J. 2010 Jul 15;429(2):323-33. doi: 10.1042/BJ20100231.

PMID:
20465544
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Novel role for SGK3 in glucose homeostasis revealed in SGK3/Akt2 double-null mice.

Yao LJ, McCormick JA, Wang J, Yang KY, Kidwai A, Colussi GL, Boini KM, Birnbaum MJ, Lang F, German MS, Pearce D.

Mol Endocrinol. 2011 Dec;25(12):2106-18. doi: 10.1210/me.2010-0329. Epub 2011 Oct 6.

PMID:
21980074
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

LKB1 deletion with the RIP2.Cre transgene modifies pancreatic beta-cell morphology and enhances insulin secretion in vivo.

Sun G, Tarasov AI, McGinty JA, French PM, McDonald A, Leclerc I, Rutter GA.

Am J Physiol Endocrinol Metab. 2010 Jun;298(6):E1261-73. doi: 10.1152/ajpendo.00100.2010. Epub 2010 Mar 30.

PMID:
20354156
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Physiological concentrations of interleukin-6 directly promote insulin secretion, signal transduction, nitric oxide release, and redox status in a clonal pancreatic β-cell line and mouse islets.

da Silva Krause M, Bittencourt A, Homem de Bittencourt PI Jr, McClenaghan NH, Flatt PR, Murphy C, Newsholme P.

J Endocrinol. 2012 Sep;214(3):301-11. Epub 2012 Jul 3.

PMID:
22761278
[PubMed - indexed for MEDLINE]
Free Article
7.

Adipose-specific expression, phosphorylation of Ser794 in insulin receptor substrate-1, and activation in diabetic animals of salt-inducible kinase-2.

Horike N, Takemori H, Katoh Y, Doi J, Min L, Asano T, Sun XJ, Yamamoto H, Kasayama S, Muraoka M, Nonaka Y, Okamoto M.

J Biol Chem. 2003 May 16;278(20):18440-7. Epub 2003 Mar 6.

PMID:
12624099
[PubMed - indexed for MEDLINE]
Free Article
8.

SAD-A potentiates glucose-stimulated insulin secretion as a mediator of glucagon-like peptide 1 response in pancreatic β cells.

Nie J, Lilley BN, Pan YA, Faruque O, Liu X, Zhang W, Sanes JR, Han X, Shi Y.

Mol Cell Biol. 2013 Jul;33(13):2527-34. doi: 10.1128/MCB.00285-13. Epub 2013 Apr 29.

PMID:
23629625
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Targeting AMP-activated protein kinase as a novel therapeutic approach for the treatment of metabolic disorders.

Viollet B, Mounier R, Leclerc J, Yazigi A, Foretz M, Andreelli F.

Diabetes Metab. 2007 Dec;33(6):395-402. Epub 2007 Nov 7. Review.

PMID:
17997341
[PubMed - indexed for MEDLINE]
Free Article
10.

The AMPK-related kinase SIK2 is regulated by cAMP via phosphorylation at Ser358 in adipocytes.

Henriksson E, Jones HA, Patel K, Peggie M, Morrice N, Sakamoto K, Göransson O.

Biochem J. 2012 Jun 15;444(3):503-14. doi: 10.1042/BJ20111932.

PMID:
22462548
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2.

Dentin R, Liu Y, Koo SH, Hedrick S, Vargas T, Heredia J, Yates J 3rd, Montminy M.

Nature. 2007 Sep 20;449(7160):366-9. Epub 2007 Sep 5.

PMID:
17805301
[PubMed - indexed for MEDLINE]
12.

AMP-activated protein kinase is activated by low glucose in cell lines derived from pancreatic beta cells, and may regulate insulin release.

Salt IP, Johnson G, Ashcroft SJ, Hardie DG.

Biochem J. 1998 Nov 1;335 ( Pt 3):533-9.

PMID:
9794792
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Inhibition of pancreatic β-cell Ca2+/calmodulin-dependent protein kinase II reduces glucose-stimulated calcium influx and insulin secretion, impairing glucose tolerance.

Dadi PK, Vierra NC, Ustione A, Piston DW, Colbran RJ, Jacobson DA.

J Biol Chem. 2014 May 2;289(18):12435-45. doi: 10.1074/jbc.M114.562587. Epub 2014 Mar 13.

PMID:
24627477
[PubMed - indexed for MEDLINE]
14.

Overexpression of p35 in Min6 pancreatic beta cells induces a stressed neuron-like apoptosis.

Zheng YL, Hu YF, Zhang A, Wang W, Li B, Amin N, Grant P, Pant HC.

J Neurol Sci. 2010 Dec 15;299(1-2):101-7. doi: 10.1016/j.jns.2010.08.067.

PMID:
20926102
[PubMed - indexed for MEDLINE]
15.

Synapses of amphids defective (SAD-A) kinase promotes glucose-stimulated insulin secretion through activation of p21-activated kinase (PAK1) in pancreatic β-Cells.

Nie J, Sun C, Faruque O, Ye G, Li J, Liang Q, Chang Z, Yang W, Han X, Shi Y.

J Biol Chem. 2012 Jul 27;287(31):26435-44. doi: 10.1074/jbc.M112.378372. Epub 2012 Jun 5.

PMID:
22669945
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

alpha-lipoic acid regulates AMP-activated protein kinase and inhibits insulin secretion from beta cells.

Targonsky ED, Dai F, Koshkin V, Karaman GT, Gyulkhandanyan AV, Zhang Y, Chan CB, Wheeler MB.

Diabetologia. 2006 Jul;49(7):1587-98. Epub 2006 May 13.

PMID:
16752177
[PubMed - indexed for MEDLINE]
17.

CRFR1 is expressed on pancreatic beta cells, promotes beta cell proliferation, and potentiates insulin secretion in a glucose-dependent manner.

Huising MO, van der Meulen T, Vaughan JM, Matsumoto M, Donaldson CJ, Park H, Billestrup N, Vale WW.

Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):912-7. doi: 10.1073/pnas.0913610107. Epub 2009 Dec 22.

PMID:
20080775
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Beta-cell uncoupling protein 2 regulates reactive oxygen species production, which influences both insulin and glucagon secretion.

Robson-Doucette CA, Sultan S, Allister EM, Wikstrom JD, Koshkin V, Bhattacharjee A, Prentice KJ, Sereda SB, Shirihai OS, Wheeler MB.

Diabetes. 2011 Nov;60(11):2710-9. doi: 10.2337/db11-0132. Epub 2011 Oct 7.

PMID:
21984579
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Cdk5-dependent regulation of glucose-stimulated insulin secretion.

Wei FY, Nagashima K, Ohshima T, Saheki Y, Lu YF, Matsushita M, Yamada Y, Mikoshiba K, Seino Y, Matsui H, Tomizawa K.

Nat Med. 2005 Oct;11(10):1104-8. Epub 2005 Sep 11.

PMID:
16155576
[PubMed - indexed for MEDLINE]
20.

Glucose-induced expression of the cyclin-dependent protein kinase 5 activator p35 involved in Alzheimer's disease regulates insulin gene transcription in pancreatic beta-cells.

Ubeda M, Kemp DM, Habener JF.

Endocrinology. 2004 Jun;145(6):3023-31. Epub 2004 Feb 19.

PMID:
14976144
[PubMed - indexed for MEDLINE]

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