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Items: 1 to 20 of 105

1.

Study of orotidine 5'-monophosphate decarboxylase in complex with the top three OMP, BMP, and PMP ligands by molecular dynamics simulation.

Jamshidi S, Jalili S, Rafii-Tabar H.

J Biomol Struct Dyn. 2015;33(2):404-17. doi: 10.1080/07391102.2014.881303. Epub 2014 Feb 21.

PMID:
24559040
2.

Rate and Equilibrium Constants for an Enzyme Conformational Change during Catalysis by Orotidine 5'-Monophosphate Decarboxylase.

Goryanova B, Goldman LM, Ming S, Amyes TL, Gerlt JA, Richard JP.

Biochemistry. 2015 Jul 28;54(29):4555-64. doi: 10.1021/acs.biochem.5b00591. Epub 2015 Jul 14.

PMID:
26135041
3.

Mechanism of OMP decarboxylation in orotidine 5'-monophosphate decarboxylase.

Hu H, Boone A, Yang W.

J Am Chem Soc. 2008 Nov 5;130(44):14493-503. doi: 10.1021/ja801202j. Epub 2008 Oct 8.

4.

A proficient enzyme: insights on the mechanism of orotidine monophosphate decarboxylase from computer simulations.

Raugei S, Cascella M, Carloni P.

J Am Chem Soc. 2004 Dec 8;126(48):15730-7.

PMID:
15571395
5.
6.

Structural basis for the decarboxylation of orotidine 5'-monophosphate (OMP) by Plasmodium falciparum OMP decarboxylase.

Tokuoka K, Kusakari Y, Krungkrai SR, Matsumura H, Kai Y, Krungkrai J, Horii T, Inoue T.

J Biochem. 2008 Jan;143(1):69-78. Epub 2007 Nov 1.

PMID:
17981823
7.

Role of a guanidinium cation-phosphodianion pair in stabilizing the vinyl carbanion intermediate of orotidine 5'-phosphate decarboxylase-catalyzed reactions.

Goryanova B, Goldman LM, Amyes TL, Gerlt JA, Richard JP.

Biochemistry. 2013 Oct 22;52(42):7500-11. doi: 10.1021/bi401117y. Epub 2013 Oct 8.

8.
9.

Substrate binding induces domain movements in orotidine 5'-monophosphate decarboxylase.

Harris P, Poulsen JC, Jensen KF, Larsen S.

J Mol Biol. 2002 May 10;318(4):1019-29.

PMID:
12054799
10.

Structural basis for the catalytic mechanism of a proficient enzyme: orotidine 5'-monophosphate decarboxylase.

Harris P, Navarro Poulsen JC, Jensen KF, Larsen S.

Biochemistry. 2000 Apr 18;39(15):4217-24.

PMID:
10757968
11.

Catalysis by orotidine 5'-monophosphate decarboxylase: effect of 5-fluoro and 4'-substituents on the decarboxylation of two-part substrates.

Goryanova B, Spong K, Amyes TL, Richard JP.

Biochemistry. 2013 Jan 22;52(3):537-46. doi: 10.1021/bi301650d. Epub 2013 Jan 11.

13.

Dissecting the total transition state stabilization provided by amino acid side chains at orotidine 5'-monophosphate decarboxylase: a two-part substrate approach.

Barnett SA, Amyes TL, Wood BM, Gerlt JA, Richard JP.

Biochemistry. 2008 Jul 29;47(30):7785-7. doi: 10.1021/bi800939k. Epub 2008 Jul 4.

14.
15.

Chemical models and their mechanistic implications for the transformation of 6-cyanouridine 5'-monophosphate catalyzed by orotidine 5'-monophosphate decarboxylase.

Wu YJ, Liao CC, Jen CH, Shih YC, Chien TC.

Chem Commun (Camb). 2010 Jul 14;46(26):4821-3. doi: 10.1039/c001865a. Epub 2010 May 25.

PMID:
20498911
16.

An alternative explanation for the catalytic proficiency of orotidine 5'-phosphate decarboxylase.

Lee TS, Chong LT, Chodera JD, Kollman PA.

J Am Chem Soc. 2001 Dec 26;123(51):12837-48.

PMID:
11749542
17.

Mechanism of the orotidine 5'-monophosphate decarboxylase-catalyzed reaction: evidence for substrate destabilization.

Chan KK, Wood BM, Fedorov AA, Fedorov EV, Imker HJ, Amyes TL, Richard JP, Almo SC, Gerlt JA.

Biochemistry. 2009 Jun 23;48(24):5518-31. doi: 10.1021/bi900623r.

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Mechanism of the orotidine 5'-monophosphate decarboxylase-catalyzed reaction: effect of solvent viscosity on kinetic constants.

Wood BM, Chan KK, Amyes TL, Richard JP, Gerlt JA.

Biochemistry. 2009 Jun 23;48(24):5510-7. doi: 10.1021/bi9006226.

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