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Items: 1 to 20 of 111

1.

The methyltransferase G9a regulates HoxA9-dependent transcription in AML.

Lehnertz B, Pabst C, Su L, Miller M, Liu F, Yi L, Zhang R, Krosl J, Yung E, Kirschner J, Rosten P, Underhill TM, Jin J, Hébert J, Sauvageau G, Humphries RK, Rossi FM.

Genes Dev. 2014 Feb 15;28(4):317-27. doi: 10.1101/gad.236794.113.

2.

Histone methyltransferase G9a and H3K9 dimethylation inhibit the self-renewal of glioma cancer stem cells.

Tao H, Li H, Su Y, Feng D, Wang X, Zhang C, Ma H, Hu Q.

Mol Cell Biochem. 2014 Sep;394(1-2):23-30. doi: 10.1007/s11010-014-2077-4. Epub 2014 May 16.

PMID:
24833465
3.

G9a/GLP-dependent histone H3K9me2 patterning during human hematopoietic stem cell lineage commitment.

Chen X, Skutt-Kakaria K, Davison J, Ou YL, Choi E, Malik P, Loeb K, Wood B, Georges G, Torok-Storb B, Paddison PJ.

Genes Dev. 2012 Nov 15;26(22):2499-511. doi: 10.1101/gad.200329.112. Epub 2012 Oct 26.

5.
6.

A SALL4/MLL/HOXA9 pathway in murine and human myeloid leukemogenesis.

Li A, Yang Y, Gao C, Lu J, Jeong HW, Liu BH, Tang P, Yao X, Neuberg D, Huang G, Tenen DG, Chai L.

J Clin Invest. 2013 Oct;123(10):4195-207. doi: 10.1172/JCI62891. Epub 2013 Sep 24.

7.

Transcription factor AP-2α regulates acute myeloid leukemia cell proliferation by influencing Hoxa gene expression.

Ding X, Yang Z, Zhou F, Wang F, Li X, Chen C, Li X, Hu X, Xiang S, Zhang J.

Int J Biochem Cell Biol. 2013 Aug;45(8):1647-56. doi: 10.1016/j.biocel.2013.04.024. Epub 2013 May 6.

PMID:
23660297
8.

Discovery of novel small molecule inhibitors of lysine methyltransferase G9a and their mechanism in leukemia cell lines.

Kondengaden SM, Luo LF, Huang K, Zhu M, Zang L, Bataba E, Wang R, Luo C, Wang B, Li KK, Wang PG.

Eur J Med Chem. 2016 Oct 21;122:382-93. doi: 10.1016/j.ejmech.2016.06.028. Epub 2016 Jun 21.

PMID:
27393948
9.

Histone-lysine methyltransferase EHMT2 is involved in proliferation, apoptosis, cell invasion, and DNA methylation of human neuroblastoma cells.

Lu Z, Tian Y, Salwen HR, Chlenski A, Godley LA, Raj JU, Yang Q.

Anticancer Drugs. 2013 Jun;24(5):484-93. doi: 10.1097/CAD.0b013e32835ffdbb.

10.

Gfi1 coordinates epigenetic repression of p21Cip/WAF1 by recruitment of histone lysine methyltransferase G9a and histone deacetylase 1.

Duan Z, Zarebski A, Montoya-Durango D, Grimes HL, Horwitz M.

Mol Cell Biol. 2005 Dec;25(23):10338-51.

11.

Leukemic transformation of hematopoietic progenitors by MLL-GAS7 in the absence of Hoxa7 or Hoxa9.

So CW, Karsunky H, Wong P, Weissman IL, Cleary ML.

Blood. 2004 Apr 15;103(8):3192-9. Epub 2003 Dec 30.

12.

Constitutive activation of Flt3 and STAT5A enhances self-renewal and alters differentiation of hematopoietic stem cells.

Moore MA, Dorn DC, Schuringa JJ, Chung KY, Morrone G.

Exp Hematol. 2007 Apr;35(4 Suppl 1):105-16.

PMID:
17379095
13.

MLL1 and DOT1L cooperate with meningioma-1 to induce acute myeloid leukemia.

Riedel SS, Haladyna JN, Bezzant M, Stevens B, Pollyea DA, Sinha AU, Armstrong SA, Wei Q, Pollock RM, Daigle SR, Jordan CT, Ernst P, Neff T, Bernt KM.

J Clin Invest. 2016 Apr 1;126(4):1438-50. doi: 10.1172/JCI80825. Epub 2016 Feb 29.

14.

Recruitment of histone methyltransferase G9a mediates transcriptional repression of Fgf21 gene by E4BP4 protein.

Tong X, Zhang D, Buelow K, Guha A, Arthurs B, Brady HJ, Yin L.

J Biol Chem. 2013 Feb 22;288(8):5417-25. doi: 10.1074/jbc.M112.433482. Epub 2013 Jan 2.

15.

Cdx4 dysregulates Hox gene expression and generates acute myeloid leukemia alone and in cooperation with Meis1a in a murine model.

Bansal D, Scholl C, Fröhling S, McDowell E, Lee BH, Döhner K, Ernst P, Davidson AJ, Daley GQ, Zon LI, Gilliland DG, Huntly BJ.

Proc Natl Acad Sci U S A. 2006 Nov 7;103(45):16924-9. Epub 2006 Oct 26.

16.

A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells.

Vedadi M, Barsyte-Lovejoy D, Liu F, Rival-Gervier S, Allali-Hassani A, Labrie V, Wigle TJ, Dimaggio PA, Wasney GA, Siarheyeva A, Dong A, Tempel W, Wang SC, Chen X, Chau I, Mangano TJ, Huang XP, Simpson CD, Pattenden SG, Norris JL, Kireev DB, Tripathy A, Edwards A, Roth BL, Janzen WP, Garcia BA, Petronis A, Ellis J, Brown PJ, Frye SV, Arrowsmith CH, Jin J.

Nat Chem Biol. 2011 Jul 10;7(8):566-74. doi: 10.1038/nchembio.599. Erratum in: Nat Chem Biol. 2011 Sep;7(9):648. Nat Chem Biol. 2011;7(8):following 574.

17.

A histone acetyltransferase p300 inhibitor C646 induces cell cycle arrest and apoptosis selectively in AML1-ETO-positive AML cells.

Gao XN, Lin J, Ning QY, Gao L, Yao YS, Zhou JH, Li YH, Wang LL, Yu L.

PLoS One. 2013;8(2):e55481. doi: 10.1371/journal.pone.0055481. Epub 2013 Feb 4.

18.

c-Met inhibition in a HOXA9/Meis1 model of CN-AML.

Mulgrew NM, Kettyle LM, Ramsey JM, Cull S, Smyth LJ, Mervyn DM, Bijl JJ, Thompson A.

Dev Dyn. 2014 Jan;243(1):172-81. doi: 10.1002/dvdy.24070. Epub 2013 Dec 4.

19.

Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia.

Grebien F, Vedadi M, Getlik M, Giambruno R, Grover A, Avellino R, Skucha A, Vittori S, Kuznetsova E, Smil D, Barsyte-Lovejoy D, Li F, Poda G, Schapira M, Wu H, Dong A, Senisterra G, Stukalov A, Huber KV, Schönegger A, Marcellus R, Bilban M, Bock C, Brown PJ, Zuber J, Bennett KL, Al-Awar R, Delwel R, Nerlov C, Arrowsmith CH, Superti-Furga G.

Nat Chem Biol. 2015 Aug;11(8):571-8. doi: 10.1038/nchembio.1859. Epub 2015 Jul 13. Erratum in: Nat Chem Biol. 2015 Oct;11(10):815.

20.

The histone methyltransferase inhibitor, DZNep, up-regulates TXNIP, increases ROS production, and targets leukemia cells in AML.

Zhou J, Bi C, Cheong LL, Mahara S, Liu SC, Tay KG, Koh TL, Yu Q, Chng WJ.

Blood. 2011 Sep 8;118(10):2830-9. doi: 10.1182/blood-2010-07-294827. Epub 2011 Jul 6.

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