Sort by

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 116


Cot/tpl2 participates in the activation of macrophages by adiponectin.

Sanz-Garcia C, Nagy LE, Lasunción MA, Fernandez M, Alemany S.

J Leukoc Biol. 2014 Jun;95(6):917-30. doi: 10.1189/jlb.0913486. Epub 2014 Feb 14.


Cot/tpl2 activity is required for TLR-induced activation of the Akt p70 S6k pathway in macrophages: Implications for NO synthase 2 expression.

López-Peláez M, Soria-Castro I, Boscá L, Fernández M, Alemany S.

Eur J Immunol. 2011 Jun;41(6):1733-41. doi: 10.1002/eji.201041101. Epub 2011 May 24.


Sensitivity of TLR4- and -7-induced NF kappa B1 p105-TPL2-ERK pathway to TNF-receptor-associated-factor-6 revealed by RNAi in mouse macrophages.

Loniewski KJ, Patial S, Parameswaran N.

Mol Immunol. 2007 Jul;44(15):3715-23. Epub 2007 May 15.


Cot/Tpl2 regulates IL-23 p19 expression in LPS-stimulated macrophages through ERK activation.

Kakimoto K, Musikacharoen T, Chiba N, Bandow K, Ohnishi T, Matsuguchi T.

J Physiol Biochem. 2010 Mar;66(1):47-53. doi: 10.1007/s13105-010-0007-9. Epub 2010 Apr 20.


Sterile inflammation in acetaminophen-induced liver injury is mediated by Cot/tpl2.

Sanz-Garcia C, Ferrer-Mayorga G, González-Rodríguez Á, Valverde AM, Martín-Duce A, Velasco-Martín JP, Regadera J, Fernández M, Alemany S.

J Biol Chem. 2013 May 24;288(21):15342-51. doi: 10.1074/jbc.M112.439547. Epub 2013 Apr 9.


Deregulation of Tpl2 and NF-kappaB signaling and induction of macrophage apoptosis by the anti-depressant drug lithium.

Zhang M, Jin W, Zhou X, Yu J, Lee AJ, Sun SC.

Cell Signal. 2009 Apr;21(4):559-66. doi: 10.1016/j.cellsig.2008.12.010. Epub 2008 Dec 25.


Cot/tpl2-MKK1/2-Erk1/2 controls mTORC1-mediated mRNA translation in Toll-like receptor-activated macrophages.

López-Pelaéz M, Fumagalli S, Sanz C, Herrero C, Guerra S, Fernandez M, Alemany S.

Mol Biol Cell. 2012 Aug;23(15):2982-92. doi: 10.1091/mbc.E12-02-0135. Epub 2012 Jun 6.


Tpl2 kinase is upregulated in adipose tissue in obesity and may mediate interleukin-1beta and tumor necrosis factor-{alpha} effects on extracellular signal-regulated kinase activation and lipolysis.

Jager J, Grémeaux T, Gonzalez T, Bonnafous S, Debard C, Laville M, Vidal H, Tran A, Gual P, Le Marchand-Brustel Y, Cormont M, Tanti JF.

Diabetes. 2010 Jan;59(1):61-70. doi: 10.2337/db09-0470. Epub 2009 Oct 6.


Tumor progression locus 2-dependent oxidative burst drives phosphorylation of extracellular signal-regulated kinase during TLR3 and 9 signaling.

Kuriakose T, Rada B, Watford WT.

J Biol Chem. 2014 Dec 26;289(52):36089-100. doi: 10.1074/jbc.M114.587121. Epub 2014 Nov 5.


TRAF6 and Src kinase activity regulates Cot activation by IL-1.

Rodríguez C, Pozo M, Nieto E, Fernández M, Alemany S.

Cell Signal. 2006 Sep;18(9):1376-85. Epub 2005 Dec 20.


A serine/threonine kinase, Cot/Tpl2, modulates bacterial DNA-induced IL-12 production and Th cell differentiation.

Sugimoto K, Ohata M, Miyoshi J, Ishizaki H, Tsuboi N, Masuda A, Yoshikai Y, Takamoto M, Sugane K, Matsuo S, Shimada Y, Matsuguchi T.

J Clin Invest. 2004 Sep;114(6):857-66.


Deregulated activation of oncoprotein kinase Tpl2/Cot in HTLV-I-transformed T cells.

Babu G, Waterfield M, Chang M, Wu X, Sun SC.

J Biol Chem. 2006 May 19;281(20):14041-7. Epub 2006 Mar 24.


Functional roles of Cot/Tpl2 in mast cell responses to lipopolysaccharide and FcεRI-clustering.

Chiba N, Kakimoto K, Masuda A, Matsuguchi T.

Biochem Biophys Res Commun. 2010 Nov 5;402(1):1-6. doi: 10.1016/j.bbrc.2010.08.075. Epub 2010 Aug 21.


The Tpl2 Kinase Regulates the COX-2/Prostaglandin E2 Axis in Adipocytes in Inflammatory Conditions.

Berthou F, Ceppo F, Dumas K, Massa F, Vergoni B, Alemany S, Cormont M, Tanti JF.

Mol Endocrinol. 2015 Jul;29(7):1025-36. Epub 2015 May 28.


Cot/tpl2 (MAP3K8) mediates myeloperoxidase activity and hypernociception following peripheral inflammation.

Soria-Castro I, Krzyzanowska A, Pelaéz ML, Regadera J, Ferrer G, Montoliu L, Rodríguez-Ramos R, Fernández M, Alemany S.

J Biol Chem. 2010 Oct 29;285(44):33805-15. doi: 10.1074/jbc.M110.169409. Epub 2010 Aug 24.


Induction of COX-2 by LPS in macrophages is regulated by Tpl2-dependent CREB activation signals.

Eliopoulos AG, Dumitru CD, Wang CC, Cho J, Tsichlis PN.

EMBO J. 2002 Sep 16;21(18):4831-40.


Tumor progression locus 2 (Map3k8) is critical for host defense against Listeria monocytogenes and IL-1 beta production.

Mielke LA, Elkins KL, Wei L, Starr R, Tsichlis PN, O'Shea JJ, Watford WT.

J Immunol. 2009 Dec 15;183(12):7984-93. doi: 10.4049/jimmunol.0901336. Epub .


Phosphorylation of NF-kappaB1/p105 by oncoprotein kinase Tpl2: implications for a novel mechanism of Tpl2 regulation.

Babu GR, Jin W, Norman L, Waterfield M, Chang M, Wu X, Zhang M, Sun SC.

Biochim Biophys Acta. 2006 Feb;1763(2):174-81. Epub 2006 Jan 13.


Tpl2/cot signals activate ERK, JNK, and NF-kappaB in a cell-type and stimulus-specific manner.

Das S, Cho J, Lambertz I, Kelliher MA, Eliopoulos AG, Du K, Tsichlis PN.

J Biol Chem. 2005 Jun 24;280(25):23748-57. Epub 2005 Apr 15.

Items per page

Supplemental Content

Write to the Help Desk