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Involvement of RECK in gambogic acid induced anti-invasive effect in A549 human lung carcinoma cells.

Qi Q, Lu N, Li C, Zhao J, Liu W, You Q, Guo Q.

Mol Carcinog. 2015 Jun;54 Suppl 1:E13-25. doi: 10.1002/mc.22138. Epub 2014 Feb 14.


HER-2/neu represses the metastasis suppressor RECK via ERK and Sp transcription factors to promote cell invasion.

Hsu MC, Chang HC, Hung WC.

J Biol Chem. 2006 Feb 24;281(8):4718-25. Epub 2005 Dec 23.


Angiotensin II stimulates cardiac fibroblast migration via the differential regulation of matrixins and RECK.

Siddesha JM, Valente AJ, Sakamuri SS, Yoshida T, Gardner JD, Somanna N, Takahashi C, Noda M, Chandrasekar B.

J Mol Cell Cardiol. 2013 Dec;65:9-18. doi: 10.1016/j.yjmcc.2013.09.015. Epub 2013 Oct 2.


Histone deacetylase inhibitor up-regulates RECK to inhibit MMP-2 activation and cancer cell invasion.

Liu LT, Chang HC, Chiang LC, Hung WC.

Cancer Res. 2003 Jun 15;63(12):3069-72.


Ras induces experimental lung metastasis through up-regulation of RbAp46 to suppress RECK promoter activity.

Yeh HH, Tseng YF, Hsu YC, Lan SH, Wu SY, Raghavaraju G, Cheng DE, Lee YR, Chang TY, Chow NH, Hung WC, Liu HS.

BMC Cancer. 2015 Mar 25;15:172. doi: 10.1186/s12885-015-1155-7.


The Kazal motifs of RECK protein inhibit MMP-9 secretion and activity and reduce metastasis of lung cancer cells in vitro and in vivo.

Chang CK, Hung WC, Chang HC.

J Cell Mol Med. 2008 Dec;12(6B):2781-9. doi: 10.1111/j.1582-4934.2008.00215.x. Epub 2008 Jan 11.


Suppression of NF-κB signaling and P-glycoprotein function by gambogic acid synergistically potentiates adriamycin -induced apoptosis in lung cancer.

Wang LH, Yang JY, Yang SN, Li Y, Ping GF, Hou Y, Cui W, Wang ZZ, Xiao W, Wu CF.

Curr Cancer Drug Targets. 2014;14(1):91-103.


RECK is a target of Epstein-Barr virus latent membrane protein 1.

Liu LT, Peng JP, Chang HC, Hung WC.

Oncogene. 2003 Nov 13;22(51):8263-70.


Gambogic acid synergistically potentiates cisplatin-induced apoptosis in non-small-cell lung cancer through suppressing NF-κB and MAPK/HO-1 signalling.

Wang LH, Li Y, Yang SN, Wang FY, Hou Y, Cui W, Chen K, Cao Q, Wang S, Zhang TY, Wang ZZ, Xiao W, Yang JY, Wu CF.

Br J Cancer. 2014 Jan 21;110(2):341-52. doi: 10.1038/bjc.2013.752. Epub 2013 Dec 3.


Cytochrome P450 ω-hydroxylase promotes angiogenesis and metastasis by upregulation of VEGF and MMP-9 in non-small cell lung cancer.

Yu W, Chen L, Yang YQ, Falck JR, Guo AM, Li Y, Yang J.

Cancer Chemother Pharmacol. 2011 Sep;68(3):619-29. doi: 10.1007/s00280-010-1521-8. Epub 2010 Dec 1.


Regulation of cell invasion and signalling pathways in the pituitary adenoma cell line, HP-75, by reversion-inducing cysteine-rich protein with kazal motifs (RECK).

Yoshida D, Nomura R, Teramoto A.

J Neurooncol. 2008 Sep;89(2):141-50. doi: 10.1007/s11060-008-9606-5. Epub 2008 May 21.


Induction of RECK by nonsteroidal anti-inflammatory drugs in lung cancer cells.

Liu LT, Chang HC, Chiang LC, Hung WC.

Oncogene. 2002 Nov 28;21(54):8347-50.


Inhibition of histone deacetylase attenuates hypoxia-induced migration and invasion of cancer cells via the restoration of RECK expression.

Jeon HW, Lee YM.

Mol Cancer Ther. 2010 May;9(5):1361-70. doi: 10.1158/1535-7163.MCT-09-0717. Epub 2010 May 4.


Tomatidine inhibits invasion of human lung adenocarcinoma cell A549 by reducing matrix metalloproteinases expression.

Yan KH, Lee LM, Yan SH, Huang HC, Li CC, Lin HT, Chen PS.

Chem Biol Interact. 2013 May 25;203(3):580-7. doi: 10.1016/j.cbi.2013.03.016. Epub 2013 Apr 6.


Inhibition of miR-92b suppresses nonsmall cell lung cancer cells growth and motility by targeting RECK.

Lei L, Huang Y, Gong W.

Mol Cell Biochem. 2014 Feb;387(1-2):171-6. doi: 10.1007/s11010-013-1882-5. Epub 2013 Oct 27.


RECK inhibits stemness gene expression and tumorigenicity of gastric cancer cells by suppressing ADAM-mediated Notch1 activation.

Hong KJ, Wu DC, Cheng KH, Chen LT, Hung WC.

J Cell Physiol. 2014 Feb;229(2):191-201. doi: 10.1002/jcp.24434.


Gambogic acid inhibits TNF-α-induced invasion of human prostate cancer PC3 cells in vitro through PI3K/Akt and NF-κB signaling pathways.

Lü L, Tang D, Wang L, Huang LQ, Jiang GS, Xiao XY, Zeng FQ.

Acta Pharmacol Sin. 2012 Apr;33(4):531-41. doi: 10.1038/aps.2011.180. Epub 2012 Mar 19.

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