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The PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses.

Khare S, Ratsimandresy RA, de Almeida L, Cuda CM, Rellick SL, Misharin AV, Wallin MC, Gangopadhyay A, Forte E, Gottwein E, Perlman H, Reed JC, Greaves DR, Dorfleutner A, Stehlik C.

Nat Immunol. 2014 Apr;15(4):343-53. doi: 10.1038/ni.2829. Epub 2014 Feb 16.


The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses.

Rathinam VA, Jiang Z, Waggoner SN, Sharma S, Cole LE, Waggoner L, Vanaja SK, Monks BG, Ganesan S, Latz E, Hornung V, Vogel SN, Szomolanyi-Tsuda E, Fitzgerald KA.

Nat Immunol. 2010 May;11(5):395-402. doi: 10.1038/ni.1864. Epub 2010 Mar 28.


POP goes the inflammasome.

Krishnaswamy JK, Liu D, Eisenbarth SC.

Nat Immunol. 2014 Apr;15(4):311-3. doi: 10.1038/ni.2848. No abstract available.


The CARD plays a critical role in ASC foci formation and inflammasome signalling.

Proell M, Gerlic M, Mace PD, Reed JC, Riedl SJ.

Biochem J. 2013 Feb 1;449(3):613-21. doi: 10.1042/BJ20121198.


Inhibiting the inflammasome: one domain at a time.

Dorfleutner A, Chu L, Stehlik C.

Immunol Rev. 2015 May;265(1):205-16. doi: 10.1111/imr.12290. Review.


Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes.

Lu A, Magupalli VG, Ruan J, Yin Q, Atianand MK, Vos MR, Schröder GF, Fitzgerald KA, Wu H, Egelman EH.

Cell. 2014 Mar 13;156(6):1193-206. doi: 10.1016/j.cell.2014.02.008.


Inflammasomes: guardians of cytosolic sanctity.

Lamkanfi M, Dixit VM.

Immunol Rev. 2009 Jan;227(1):95-105. doi: 10.1111/j.1600-065X.2008.00730.x. Review.


Critical role of ASC inflammasomes and bacterial type IV secretion system in caspase-1 activation and host innate resistance to Brucella abortus infection.

Gomes MT, Campos PC, Oliveira FS, Corsetti PP, Bortoluci KR, Cunha LD, Zamboni DS, Oliveira SC.

J Immunol. 2013 Apr 1;190(7):3629-38. doi: 10.4049/jimmunol.1202817. Epub 2013 Mar 4.


The emerging role of human PYHIN proteins in innate immunity: implications for health and disease.

Connolly DJ, Bowie AG.

Biochem Pharmacol. 2014 Dec 1;92(3):405-14. doi: 10.1016/j.bcp.2014.08.031. Epub 2014 Sep 6.


AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC.

Sagulenko V, Thygesen SJ, Sester DP, Idris A, Cridland JA, Vajjhala PR, Roberts TL, Schroder K, Vince JE, Hill JM, Silke J, Stacey KJ.

Cell Death Differ. 2013 Sep;20(9):1149-60. doi: 10.1038/cdd.2013.37. Epub 2013 May 3.


Involvement of the AIM2, NLRC4, and NLRP3 inflammasomes in caspase-1 activation by Listeria monocytogenes.

Wu J, Fernandes-Alnemri T, Alnemri ES.

J Clin Immunol. 2010 Sep;30(5):693-702. doi: 10.1007/s10875-010-9425-2. Epub 2010 May 20.


Multiple binding sites on the pyrin domain of ASC protein allow self-association and interaction with NLRP3 protein.

Vajjhala PR, Mirams RE, Hill JM.

J Biol Chem. 2012 Dec 7;287(50):41732-43. doi: 10.1074/jbc.M112.381228. Epub 2012 Oct 12.


Mycobacterium abscessus activates the NLRP3 inflammasome via Dectin-1-Syk and p62/SQSTM1.

Lee HM, Yuk JM, Kim KH, Jang J, Kang G, Park JB, Son JW, Jo EK.

Immunol Cell Biol. 2012 Jul;90(6):601-10. doi: 10.1038/icb.2011.72. Epub 2011 Aug 30.


IFI16 protein mediates the anti-inflammatory actions of the type-I interferons through suppression of activation of caspase-1 by inflammasomes.

Veeranki S, Duan X, Panchanathan R, Liu H, Choubey D.

PLoS One. 2011;6(10):e27040. doi: 10.1371/journal.pone.0027040. Epub 2011 Oct 28.


Structure of the absent in melanoma 2 (AIM2) pyrin domain provides insights into the mechanisms of AIM2 autoinhibition and inflammasome assembly.

Jin T, Perry A, Smith P, Jiang J, Xiao TS.

J Biol Chem. 2013 May 10;288(19):13225-35. doi: 10.1074/jbc.M113.468033. Epub 2013 Mar 25.


Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation.

Dowling JK, Becker CE, Bourke NM, Corr SC, Connolly DJ, Quinn SR, Pandolfi PP, Mansell A, O'Neill LA.

J Biol Chem. 2014 Mar 7;289(10):6429-37. doi: 10.1074/jbc.M113.539692. Epub 2014 Jan 9.


The nucleic acid-sensing inflammasomes.

Xiao TS.

Immunol Rev. 2015 May;265(1):103-11. doi: 10.1111/imr.12281. Review.


Identification of multifaceted binding modes for pyrin and ASC pyrin domains gives insights into pyrin inflammasome assembly.

Vajjhala PR, Kaiser S, Smith SJ, Ong QR, Soh SL, Stacey KJ, Hill JM.

J Biol Chem. 2014 Aug 22;289(34):23504-19. doi: 10.1074/jbc.M114.553305. Epub 2014 Jul 8.


GBP5 promotes NLRP3 inflammasome assembly and immunity in mammals.

Shenoy AR, Wellington DA, Kumar P, Kassa H, Booth CJ, Cresswell P, MacMicking JD.

Science. 2012 Apr 27;336(6080):481-5. doi: 10.1126/science.1217141. Epub 2012 Mar 29.

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