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Items: 1 to 20 of 91

1.

Consideration of the unbound drug concentration in enzyme kinetics.

Waters NJ, Obach RS, Di L.

Methods Mol Biol. 2014;1113:119-45. doi: 10.1007/978-1-62703-758-7_7. Review.

PMID:
24523111
2.

Commentary: nonspecific protein binding versus membrane partitioning: it is not just semantics.

Nagar S, Korzekwa K.

Drug Metab Dispos. 2012 Sep;40(9):1649-52. doi: 10.1124/dmd.112.046599. Epub 2012 Jun 18.

3.

Enzyme kinetics in drug metabolism: fundamentals and applications.

Nagar S, Argikar UA, Tweedie DJ.

Methods Mol Biol. 2014;1113:1-6. doi: 10.1007/978-1-62703-758-7_1.

PMID:
24523105
4.

Hepatic elimination of drugs with concentration-dependent serum protein binding.

Huang JD, Oie S.

J Pharmacokinet Biopharm. 1984 Feb;12(1):67-81.

PMID:
6747819
5.

The bioanalytical challenge of determining unbound concentration and protein binding for drugs.

Nilsson LB.

Bioanalysis. 2013 Dec;5(24):3033-50. doi: 10.4155/bio.13.274. Review.

PMID:
24320129
6.

Nonspecific binding of drugs to human liver microsomes.

McLure JA, Miners JO, Birkett DJ.

Br J Clin Pharmacol. 2000 May;49(5):453-61.

7.

Accumulation kinetics of drugs with nonlinear plasma protein and tissue binding characteristics.

McNamara PJ, Slattery JT, Gibaldi M, Levy G.

J Pharmacokinet Biopharm. 1979 Aug;7(4):397-405.

PMID:
512845
8.

Effect of plasma protein and tissue binding on the time course of drug concentration in plasma.

McNamara PJ, Levy G, Gibaldi M.

J Pharmacokinet Biopharm. 1979 Apr;7(2):195-206.

PMID:
20218014
9.

Do we need to optimize plasma protein and tissue binding in drug discovery?

Liu X, Chen C, Hop CE.

Curr Top Med Chem. 2011;11(4):450-66. Review.

PMID:
21320069
10.

Studying cytochrome P450 kinetics in drug metabolism.

Kramer MA, Tracy TS.

Expert Opin Drug Metab Toxicol. 2008 May;4(5):591-603. doi: 10.1517/17425255.4.5.591 . Review.

PMID:
18484917
11.

Case study 3. Application of basic enzyme kinetics to metabolism studies: real-life examples.

Li Y, McCabe M, Podila L, Tracy TS, Tweedie DJ.

Methods Mol Biol. 2014;1113:441-60. doi: 10.1007/978-1-62703-758-7_20.

PMID:
24523124
12.

Systems biology approaches to enzyme kinetics: analyzing network models of drug metabolism.

Finn NA, Kemp ML.

Methods Mol Biol. 2014;1113:317-34. doi: 10.1007/978-1-62703-758-7_15.

PMID:
24523119
14.
15.

Measurement and analysis of unbound drug concentrations.

Wright JD, Boudinot FD, Ujhelyi MR.

Clin Pharmacokinet. 1996 Jun;30(6):445-62. Review.

PMID:
8792057
16.

Impact of pH on plasma protein binding in equilibrium dialysis.

Kochansky CJ, McMasters DR, Lu P, Koeplinger KA, Kerr HH, Shou M, Korzekwa KR.

Mol Pharm. 2008 May-Jun;5(3):438-48. doi: 10.1021/mp800004s. Epub 2008 Mar 18.

PMID:
18345638
17.

In vitro-in vivo scaling of CYP kinetic data not consistent with the classical Michaelis-Menten model.

Houston JB, Kenworthy KE.

Drug Metab Dispos. 2000 Mar;28(3):246-54. Review.

18.

Determination of drug binding to plasma proteins using competitive equilibrium binding to dextran-coated charcoal.

Berezhkovskiy LM.

J Pharmacokinet Pharmacodyn. 2006 Oct;33(5):595-608. Epub 2006 Jul 14.

PMID:
16841186
20.
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