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Novel mechanistic insights into ectodomain shedding of EGFR Ligands Amphiregulin and TGF-α: impact on gastrointestinal cancers driven by secondary bile acids.

Nagathihalli NS, Beesetty Y, Lee W, Washington MK, Chen X, Lockhart AC, Merchant NB.

Cancer Res. 2014 Apr 1;74(7):2062-72. doi: 10.1158/0008-5472.CAN-13-2329. Epub 2014 Feb 11.


TACE/ADAM-17: a component of the epidermal growth factor receptor axis and a promising therapeutic target in colorectal cancer.

Merchant NB, Voskresensky I, Rogers CM, Lafleur B, Dempsey PJ, Graves-Deal R, Revetta F, Foutch AC, Rothenberg ML, Washington MK, Coffey RJ.

Clin Cancer Res. 2008 Feb 15;14(4):1182-91. doi: 10.1158/1078-0432.CCR-07-1216.


Ligand-dependent activation of the epidermal growth factor receptor by secondary bile acids in polarizing colon cancer cells.

Merchant NB, Rogers CM, Trivedi B, Morrow J, Coffey RJ.

Surgery. 2005 Sep;138(3):415-21.


ADAM-mediated amphiregulin shedding and EGFR transactivation.

Kasina S, Scherle PA, Hall CL, Macoska JA.

Cell Prolif. 2009 Dec;42(6):799-812. doi: 10.1111/j.1365-2184.2009.00645.x. Epub 2009 Sep 7.


SRC family kinases mediate epidermal growth factor receptor ligand cleavage, proliferation, and invasion of head and neck cancer cells.

Zhang Q, Thomas SM, Xi S, Smithgall TE, Siegfried JM, Kamens J, Gooding WE, Grandis JR.

Cancer Res. 2004 Sep 1;64(17):6166-73.


Deoxycholic acid (DCA) causes ligand-independent activation of epidermal growth factor receptor (EGFR) and FAS receptor in primary hepatocytes: inhibition of EGFR/mitogen-activated protein kinase-signaling module enhances DCA-induced apoptosis.

Qiao L, Studer E, Leach K, McKinstry R, Gupta S, Decker R, Kukreja R, Valerie K, Nagarkatti P, El Deiry W, Molkentin J, Schmidt-Ullrich R, Fisher PB, Grant S, Hylemon PB, Dent P.

Mol Biol Cell. 2001 Sep;12(9):2629-45.


Reconstitution of amphiregulin-epidermal growth factor receptor signaling in lung squamous cell carcinomas activates PTHrP gene expression and contributes to cancer-mediated diseases of the bone.

Gilmore JL, Gonterman RM, Menon K, Lorch G, Riese DJ 2nd, Robling A, Foley J.

Mol Cancer Res. 2009 Oct;7(10):1714-28. doi: 10.1158/1541-7786.MCR-09-0131. Epub 2009 Oct 13.


ERK1/2 mediate wounding- and G-protein-coupled receptor ligands-induced EGFR activation via regulating ADAM17 and HB-EGF shedding.

Yin J, Yu FS.

Invest Ophthalmol Vis Sci. 2009 Jan;50(1):132-9. doi: 10.1167/iovs.08-2246. Epub 2008 Jul 24.


Src and ADAM-17-mediated shedding of transforming growth factor-alpha is a mechanism of acute resistance to TRAIL.

Van Schaeybroeck S, Kelly DM, Kyula J, Stokesberry S, Fennell DA, Johnston PG, Longley DB.

Cancer Res. 2008 Oct 15;68(20):8312-21. doi: 10.1158/0008-5472.CAN-07-6736.


TACE-dependent amphiregulin release is induced by IL-1β and promotes cell invasion in fibroblast-like synoviocytes in rheumatoid arthritis.

Liu FL, Wu CC, Chang DM.

Rheumatology (Oxford). 2014 Feb;53(2):260-9. doi: 10.1093/rheumatology/ket350. Epub 2013 Nov 6.


Knock-down of amphiregulin inhibits cellular invasion in inflammatory breast cancer.

Baillo A, Giroux C, Ethier SP.

J Cell Physiol. 2011 Oct;226(10):2691-701. doi: 10.1002/jcp.22620.


Amphiregulin exosomes increase cancer cell invasion.

Higginbotham JN, Demory Beckler M, Gephart JD, Franklin JL, Bogatcheva G, Kremers GJ, Piston DW, Ayers GD, McConnell RE, Tyska MJ, Coffey RJ.

Curr Biol. 2011 May 10;21(9):779-86. doi: 10.1016/j.cub.2011.03.043. Epub 2011 Apr 21.


EGF-related growth factors in the pathogenesis of murine ARPKD.

MacRae Dell K, Nemo R, Sweeney WE Jr, Avner ED.

Kidney Int. 2004 Jun;65(6):2018-29.


Self-reinforcing loop of amphiregulin and Y-box binding protein-1 contributes to poor outcomes in ovarian cancer.

Panupinthu N, Yu S, Zhang D, Zhang F, Gagea M, Lu Y, Grandis JR, Dunn SE, Lee HY, Mills GB.

Oncogene. 2014 May 29;33(22):2846-56. doi: 10.1038/onc.2013.259. Epub 2013 Jul 15.


Ectodomain shedding of pro-TGF-alpha is required for COX-2 induction and cell survival in renal medullary cells exposed to osmotic stress.

Küper C, Bartels H, Fraek ML, Beck FX, Neuhofer W.

Am J Physiol Cell Physiol. 2007 Dec;293(6):C1971-82. Epub 2007 Oct 17.


Targeting TACE-dependent EGFR ligand shedding in breast cancer.

Kenny PA, Bissell MJ.

J Clin Invest. 2007 Feb;117(2):337-45. Epub 2007 Jan 11.


Phosphorylation of TNF-alpha converting enzyme by gastrin-releasing peptide induces amphiregulin release and EGF receptor activation.

Zhang Q, Thomas SM, Lui VW, Xi S, Siegfried JM, Fan H, Smithgall TE, Mills GB, Grandis JR.

Proc Natl Acad Sci U S A. 2006 May 2;103(18):6901-6. Epub 2006 Apr 25.


A transforming Src mutant increases the bioavailability of EGFR ligands via stimulation of the cell-surface metalloproteinase ADAM17.

Maretzky T, Zhou W, Huang XY, Blobel CP.

Oncogene. 2011 Feb 3;30(5):611-8. doi: 10.1038/onc.2010.443. Epub 2010 Sep 27.

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