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Items: 1 to 20 of 69

1.

STAT3 Activation in Glioblastoma: Biochemical and Therapeutic Implications.

Kim JE, Patel M, Ruzevick J, Jackson CM, Lim M.

Cancers (Basel). 2014 Feb 10;6(1):376-95. doi: 10.3390/cancers6010376.

2.

On-target JAK2/STAT3 inhibition slows disease progression in orthotopic xenografts of human glioblastoma brain tumor stem cells.

Stechishin OD, Luchman HA, Ruan Y, Blough MD, Nguyen SA, Kelly JJ, Cairncross JG, Weiss S.

Neuro Oncol. 2013 Feb;15(2):198-207. doi: 10.1093/neuonc/nos302. Epub 2012 Dec 21.

3.

Inhibition of the JAK-2/STAT3 signaling pathway impedes the migratory and invasive potential of human glioblastoma cells.

Senft C, Priester M, Polacin M, Schröder K, Seifert V, Kögel D, Weissenberger J.

J Neurooncol. 2011 Feb;101(3):393-403. doi: 10.1007/s11060-010-0273-y. Epub 2010 Jun 30.

PMID:
20589525
4.

Honokiol inhibits signal transducer and activator of transcription-3 signaling, proliferation, and survival of hepatocellular carcinoma cells via the protein tyrosine phosphatase SHP-1.

Rajendran P, Li F, Shanmugam MK, Vali S, Abbasi T, Kapoor S, Ahn KS, Kumar AP, Sethi G.

J Cell Physiol. 2012 May;227(5):2184-95. doi: 10.1002/jcp.22954.

PMID:
21792937
5.

Embelin suppresses STAT3 signaling, proliferation, and survival of multiple myeloma via the protein tyrosine phosphatase PTEN.

Heo JY, Kim HJ, Kim SM, Park KR, Park SY, Kim SW, Nam D, Jang HJ, Lee SG, Ahn KS, Kim SH, Shim BS, Choi SH, Ahn KS.

Cancer Lett. 2011 Sep 1;308(1):71-80. doi: 10.1016/j.canlet.2011.04.015. Epub 2011 May 12.

PMID:
21565443
7.

STAT3-iNOS Signaling Mediates EGFRvIII-Induced Glial Proliferation and Transformation.

Puram SV, Yeung CM, Jahani-Asl A, Lin C, de la Iglesia N, Konopka G, Jackson-Grusby L, Bonni A.

J Neurosci. 2012 Jun 6;32(23):7806-18. doi: 10.1523/JNEUROSCI.3243-11.2012.

8.

Analysis of the activation status of Akt, NFkappaB, and Stat3 in human diffuse gliomas.

Wang H, Wang H, Zhang W, Huang HJ, Liao WS, Fuller GN.

Lab Invest. 2004 Aug;84(8):941-51.

9.

A novel small molecule, LLL12, inhibits STAT3 phosphorylation and activities and exhibits potent growth-suppressive activity in human cancer cells.

Lin L, Hutzen B, Li PK, Ball S, Zuo M, DeAngelis S, Foust E, Sobo M, Friedman L, Bhasin D, Cen L, Li C, Lin J.

Neoplasia. 2010 Jan;12(1):39-50.

10.

γ-Tocotrienol is a novel inhibitor of constitutive and inducible STAT3 signalling pathway in human hepatocellular carcinoma: potential role as an antiproliferative, pro-apoptotic and chemosensitizing agent.

Rajendran P, Li F, Manu KA, Shanmugam MK, Loo SY, Kumar AP, Sethi G.

Br J Pharmacol. 2011 May;163(2):283-98. doi: 10.1111/j.1476-5381.2010.01187.x.

11.

SD-1029 inhibits signal transducer and activator of transcription 3 nuclear translocation.

Duan Z, Bradner JE, Greenberg E, Levine R, Foster R, Mahoney J, Seiden MV.

Clin Cancer Res. 2006 Nov 15;12(22):6844-52.

12.
13.

A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells.

Lin L, Deangelis S, Foust E, Fuchs J, Li C, Li PK, Schwartz EB, Lesinski GB, Benson D, Lü J, Hoyt D, Lin J.

Mol Cancer. 2010 Aug 16;9:217. doi: 10.1186/1476-4598-9-217.

14.

LLL-3 inhibits STAT3 activity, suppresses glioblastoma cell growth and prolongs survival in a mouse glioblastoma model.

Fuh B, Sobo M, Cen L, Josiah D, Hutzen B, Cisek K, Bhasin D, Regan N, Lin L, Chan C, Caldas H, DeAngelis S, Li C, Li PK, Lin J.

Br J Cancer. 2009 Jan 13;100(1):106-12. doi: 10.1038/sj.bjc.6604793.

16.

Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells.

Garcia R, Bowman TL, Niu G, Yu H, Minton S, Muro-Cacho CA, Cox CE, Falcone R, Fairclough R, Parsons S, Laudano A, Gazit A, Levitzki A, Kraker A, Jove R.

Oncogene. 2001 May 3;20(20):2499-513.

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Inhibition of STAT3 and ErbB2 suppresses tumor growth, enhances radiosensitivity, and induces mitochondria-dependent apoptosis in glioma cells.

Gao L, Li F, Dong B, Zhang J, Rao Y, Cong Y, Mao B, Chen X.

Int J Radiat Oncol Biol Phys. 2010 Jul 15;77(4):1223-31. doi: 10.1016/j.ijrobp.2009.12.036. Epub 2010 Jun 19.

PMID:
20610043
20.

Activation of a pro-survival pathway IL-6/JAK2/STAT3 contributes to glial fibrillary acidic protein induction during the cholera toxin-induced differentiation of C6 malignant glioma cells.

Shu M, Zhou Y, Zhu W, Wu S, Zheng X, Yan G.

Mol Oncol. 2011 Jun;5(3):265-72. doi: 10.1016/j.molonc.2011.03.003. Epub 2011 Mar 21.

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