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Results: 1 to 20 of 105

1.

Interaction between neuronal nitric-oxide synthase and tetrahydrobiopterin revisited: studies on the nature and mechanism of tight pterin binding.

Heine CL, Kolesnik B, Schmidt R, Werner ER, Mayer B, Gorren AC.

Biochemistry. 2014 Mar 4;53(8):1284-95. doi: 10.1021/bi401307r. Epub 2014 Feb 17.

PMID:
24512289
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Tetrahydrobiopterin-free neuronal nitric oxide synthase: evidence for two identical highly anticooperative pteridine binding sites.

Gorren AC, List BM, Schrammel A, Pitters E, Hemmens B, Werner ER, Schmidt K, Mayer B.

Biochemistry. 1996 Dec 24;35(51):16735-45.

PMID:
8988010
[PubMed - indexed for MEDLINE]
3.

Thiols and neuronal nitric oxide synthase: complex formation, competitive inhibition, and enzyme stabilization.

Gorren AC, Schrammel A, Schmidt K, Mayer B.

Biochemistry. 1997 Apr 8;36(14):4360-6.

PMID:
9100033
[PubMed - indexed for MEDLINE]
4.

Oxygen-induced radical intermediates in the nNOS oxygenase domain regulated by L-arginine, tetrahydrobiopterin, and thiol.

Berka V, Wang LH, Tsai AL.

Biochemistry. 2008 Jan 8;47(1):405-20. Epub 2007 Dec 5.

PMID:
18052254
[PubMed - indexed for MEDLINE]
5.

Macrophage nitric oxide synthase: relationship between enzyme-bound tetrahydrobiopterin and synthase activity.

Hevel JM, Marletta MA.

Biochemistry. 1992 Aug 11;31(31):7160-5.

PMID:
1379468
[PubMed - indexed for MEDLINE]
6.
7.

Nitric oxide-induced autoinhibition of neuronal nitric oxide synthase in the presence of the autoxidation-resistant pteridine 5-methyltetrahydrobiopterin.

Gorren AC, Schrammel A, Riethmüller C, Schmidt K, Koesling D, Werner ER, Mayer B.

Biochem J. 2000 Apr 15;347(Pt 2):475-84.

PMID:
10749677
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Tetrahydrobiopterin inhibits monomerization and is consumed during catalysis in neuronal NO synthase.

Reif A, Fröhlich LG, Kotsonis P, Frey A, Bömmel HM, Wink DA, Pfleiderer W, Schmidt HH.

J Biol Chem. 1999 Aug 27;274(35):24921-9.

PMID:
10455167
[PubMed - indexed for MEDLINE]
Free Article
9.

Activation of neuronal nitric-oxide synthase by the 5-methyl analog of tetrahydrobiopterin. Functional evidence against reductive oxygen activation by the pterin cofactor.

Riethmüller C, Gorren AC, Pitters E, Hemmens B, Habisch HJ, Heales SJ, Schmidt K, Werner ER, Mayer B.

J Biol Chem. 1999 Jun 4;274(23):16047-51.

PMID:
10347155
[PubMed - indexed for MEDLINE]
Free Article
10.

The C331A mutant of neuronal nitric-oxide synthase is defective in arginine binding.

Martásek P, Miller RT, Liu Q, Roman LJ, Salerno JC, Migita CT, Raman CS, Gross SS, Ikeda-Saito M, Masters BS.

J Biol Chem. 1998 Dec 25;273(52):34799-805.

PMID:
9857005
[PubMed - indexed for MEDLINE]
Free Article
11.

Utilization of exogenous tetrahydrobiopterin in nitric oxide synthesis in human neuroblastoma cell line.

Choi HJ, Kim SW, Im JH, Lee SG, Kim M, Hwang O.

Neurosci Lett. 2003 Dec 4;352(2):89-92.

PMID:
14625030
[PubMed - indexed for MEDLINE]
12.

Low-temperature optical absorption spectra suggest a redox role for tetrahydrobiopterin in both steps of nitric oxide synthase catalysis.

Gorren AC, Bec N, Schrammel A, Werner ER, Lange R, Mayer B.

Biochemistry. 2000 Sep 26;39(38):11763-70.

PMID:
10995244
[PubMed - indexed for MEDLINE]
13.

Tetrahydrobiopterin synthesis. An absolute requirement for cytokine-induced nitric oxide generation by vascular smooth muscle.

Gross SS, Levi R.

J Biol Chem. 1992 Dec 25;267(36):25722-9.

PMID:
1281471
[PubMed - indexed for MEDLINE]
Free Article
14.

Tetrahydrobiopterin protects against guanabenz-mediated inhibition of neuronal nitric-oxide synthase in vitro and in vivo.

Dunbar AY, Jenkins GJ, Jianmongkol S, Nakatsuka M, Lowe ER, Lau M, Osawa Y.

Drug Metab Dispos. 2006 Sep;34(9):1448-56. Epub 2006 May 31.

PMID:
16738031
[PubMed - indexed for MEDLINE]
Free Article
15.

Single-turnover of nitric-oxide synthase in the presence of 4-amino-tetrahydrobiopterin: proposed role for tetrahydrobiopterin as a proton donor.

Sorlie M, Gorren AC, Marchal S, Shimizu T, Lange R, Andersson KK, Mayer B.

J Biol Chem. 2003 Dec 5;278(49):48602-10. Epub 2003 Sep 26.

PMID:
14514694
[PubMed - indexed for MEDLINE]
Free Article
16.

Inefficient spin trapping of superoxide in the presence of nitric-oxide: implications for studies on nitric-oxide synthase uncoupling.

Pignitter M, Gorren AC, Nedeianu S, Schmidt K, Mayer B.

Free Radic Biol Med. 2006 Aug 1;41(3):455-63. Epub 2006 Apr 22.

PMID:
16843826
[PubMed - indexed for MEDLINE]
17.

Tetrahydrobiopterin depletion and ubiquitylation of neuronal nitric oxide synthase.

Kamada Y, Jenkins GJ, Lau M, Dunbar AY, Lowe ER, Osawa Y.

Brain Res Mol Brain Res. 2005 Dec 7;142(1):19-27. Epub 2005 Oct 10.

PMID:
16216381
[PubMed - indexed for MEDLINE]
18.

Tetrahydrobiopterin binding to macrophage inducible nitric oxide synthase: heme spin shift and dimer stabilization by the potent pterin antagonist 4-amino-tetrahydrobiopterin.

Mayer B, Wu C, Gorren AC, Pfeiffer S, Schmidt K, Clark P, Stuehr DJ, Werner ER.

Biochemistry. 1997 Jul 8;36(27):8422-7.

PMID:
9204890
[PubMed - indexed for MEDLINE]
19.

Tetrahydrobiopterin (BH4), a cofactor for nNOS, restores gastric emptying and nNOS expression in female diabetic rats.

Gangula PR, Mukhopadhyay S, Ravella K, Cai S, Channon KM, Garfield RE, Pasricha PJ.

Am J Physiol Gastrointest Liver Physiol. 2010 May;298(5):G692-9. doi: 10.1152/ajpgi.00450.2009. Epub 2010 Feb 25.

PMID:
20185690
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Overexpression of neuronal nitric oxide synthase in insect cells reveals requirement of haem for tetrahydrobiopterin binding.

List BM, Klatt P, Werner ER, Schmidt K, Mayer B.

Biochem J. 1996 Apr 1;315 ( Pt 1):57-63.

PMID:
8670132
[PubMed - indexed for MEDLINE]
Free PMC Article

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