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Results: 1 to 20 of 104

1.

Metabolism of halogenated alkanes by cytochrome P450 enzymes. Aerobic oxidation versus anaerobic reduction.

Ji L, Zhang J, Liu W, de Visser SP.

Chem Asian J. 2014 Apr;9(4):1175-82. doi: 10.1002/asia.201301608. Epub 2014 Feb 5.

PMID:
24501011
[PubMed - in process]
2.

Is the bound substrate in nitric oxide synthase protonated or neutral and what is the active oxidant that performs substrate hydroxylation?

de Visser SP, Tan LS.

J Am Chem Soc. 2008 Oct 1;130(39):12961-74. doi: 10.1021/ja8010995. Epub 2008 Sep 6.

PMID:
18774806
[PubMed - indexed for MEDLINE]
4.

A proton-shuttle mechanism mediated by the porphyrin in benzene hydroxylation by cytochrome p450 enzymes.

de Visser SP, Shaik S.

J Am Chem Soc. 2003 Jun 18;125(24):7413-24.

PMID:
12797816
[PubMed - indexed for MEDLINE]
5.

Theoretical insights into the reductive metabolism of CCl4 by cytochrome P450 enzymes and the CCl4-dependent suicidal inactivation of P450.

Li XX, Zheng QC, Wang Y, Zhang HX.

Dalton Trans. 2014 Sep 16;43(39):14833-40. doi: 10.1039/c4dt02065k.

PMID:
25164482
[PubMed - in process]
6.

How is a metabolic intermediate formed in the mechanism-based inactivation of cytochrome P450 by using 1,1-dimethylhydrazine: hydrogen abstraction or nitrogen oxidation?

Hirao H, Chuanprasit P, Cheong YY, Wang X.

Chemistry. 2013 Jun 3;19(23):7361-9. doi: 10.1002/chem.201300689. Epub 2013 Apr 16.

PMID:
23592585
[PubMed - indexed for MEDLINE]
7.

Mechanisms of cytochrome P450 and peroxidase-catalyzed xenobiotic metabolism.

Hollenberg PF.

FASEB J. 1992 Jan 6;6(2):686-94. Review.

PMID:
1537457
[PubMed - indexed for MEDLINE]
Free Article
8.

The reductive metabolism of halogenated alkanes by liver microsomal cytochrome P450.

Nastainczyk W, Ahr HJ, Ullrich V.

Biochem Pharmacol. 1982 Feb 1;31(3):391-6.

PMID:
7073766
[PubMed - indexed for MEDLINE]
9.

Importance of H-abstraction in the final step of nitrosoalkane formation in the mechanism-based inactivation of cytochrome P450 by amine-containing drugs.

Hirao H, Thellamurege NM, Chuanprasit P, Xu K.

Int J Mol Sci. 2013 Dec 18;14(12):24692-705. doi: 10.3390/ijms141224692.

PMID:
24351842
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Fundamental differences of substrate hydroxylation by high-valent iron(IV)-oxo models of cytochrome P450.

Tahsini L, Bagherzadeh M, Nam W, de Visser SP.

Inorg Chem. 2009 Jul 20;48(14):6661-9. doi: 10.1021/ic900593c.

PMID:
19469505
[PubMed - indexed for MEDLINE]
12.

Mechanisms of cytochrome P450 substrate oxidation: MiniReview.

Guengerich FP.

J Biochem Mol Toxicol. 2007;21(4):163-8. Review.

PMID:
17936929
[PubMed - indexed for MEDLINE]
13.

How do azoles inhibit cytochrome P450 enzymes? A density functional study.

Balding PR, Porro CS, McLean KJ, Sutcliffe MJ, Maréchal JD, Munro AW, de Visser SP.

J Phys Chem A. 2008 Dec 18;112(50):12911-8. doi: 10.1021/jp802087w.

PMID:
18563875
[PubMed - indexed for MEDLINE]
14.

Overview on theoretical studies discriminating the two-oxidant versus two-state-reactivity models for substrate monoxygenation by cytochrome P450 enzymes.

de Visser SP, Porro CS, Quesne MG, Sainna MA, Munro AW.

Curr Top Med Chem. 2013;13(18):2218-32. Review.

PMID:
24047138
[PubMed - indexed for MEDLINE]
15.

Mechanism of cytochrome P450 2D6-catalyzed sparteine metabolism in humans.

Ebner T, Meese CO, Eichelbaum M.

Mol Pharmacol. 1995 Dec;48(6):1078-86.

PMID:
8848008
[PubMed - indexed for MEDLINE]
16.
17.

Systematic study on the mechanism of aldehyde oxidation to carboxylic acid by cytochrome P450.

Liu X, Wang Y, Han K.

J Biol Inorg Chem. 2007 Sep;12(7):1073-81. Epub 2007 Jul 28.

PMID:
17661096
[PubMed - indexed for MEDLINE]
18.

Oxidative and reductive metabolism by cytochrome P450 2E1.

Koop DR.

FASEB J. 1992 Jan 6;6(2):724-30. Review.

PMID:
1537462
[PubMed - indexed for MEDLINE]
Free Article
19.

Bioactivation of fluorinated 2-aryl-benzothiazole antitumor molecules by human cytochrome P450s 1A1 and 2W1 and deactivation by cytochrome P450 2S1.

Wang K, Guengerich FP.

Chem Res Toxicol. 2012 Aug 20;25(8):1740-51. doi: 10.1021/tx3001994. Epub 2012 Jul 10.

PMID:
22734839
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Computational evidence for α-nitrosamino radical as initial metabolite for both the P450 dealkylation and denitrosation of carcinogenic nitrosamines.

Ji L, Schüürmann G.

J Phys Chem B. 2012 Jan 19;116(2):903-12. doi: 10.1021/jp206570n. Epub 2012 Jan 9.

PMID:
22136655
[PubMed - indexed for MEDLINE]

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