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Items: 1 to 20 of 103

1.

An allosteric Sec61 inhibitor traps nascent transmembrane helices at the lateral gate.

Mackinnon AL, Paavilainen VO, Sharma A, Hegde RS, Taunton J.

Elife. 2014;3:e01483. doi: 10.7554/eLife.01483. Epub 2014 Feb 4.

2.

Secretory protein profiling reveals TNF-α inactivation by selective and promiscuous Sec61 modulators.

Maifeld SV, MacKinnon AL, Garrison JL, Sharma A, Kunkel EJ, Hegde RS, Taunton J.

Chem Biol. 2011 Sep 23;18(9):1082-8. doi: 10.1016/j.chembiol.2011.06.015.

3.

Structures of the Sec61 complex engaged in nascent peptide translocation or membrane insertion.

Gogala M, Becker T, Beatrix B, Armache JP, Barrio-Garcia C, Berninghausen O, Beckmann R.

Nature. 2014 Feb 6;506(7486):107-10. doi: 10.1038/nature12950.

PMID:
24499919
4.

Sequential triage of transmembrane segments by Sec61alpha during biogenesis of a native multispanning membrane protein.

Sadlish H, Pitonzo D, Johnson AE, Skach WR.

Nat Struct Mol Biol. 2005 Oct;12(10):870-8. Epub 2005 Sep 25.

PMID:
16186821
5.

A substrate-specific inhibitor of protein translocation into the endoplasmic reticulum.

Garrison JL, Kunkel EJ, Hegde RS, Taunton J.

Nature. 2005 Jul 14;436(7048):285-9.

PMID:
16015336
6.
7.

Sequence-specific retention and regulated integration of a nascent membrane protein by the endoplasmic reticulum Sec61 translocon.

Pitonzo D, Yang Z, Matsumura Y, Johnson AE, Skach WR.

Mol Biol Cell. 2009 Jan;20(2):685-98. doi: 10.1091/mbc.E08-09-0902. Epub 2008 Nov 19.

8.
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10.

Ribophorin I associates with a subset of membrane proteins after their integration at the sec61 translocon.

Wilson CM, Kraft C, Duggan C, Ismail N, Crawshaw SG, High S.

J Biol Chem. 2005 Feb 11;280(6):4195-206. Epub 2004 Nov 19.

11.

Structural and functional profiling of the lateral gate of the Sec61 translocon.

Reithinger JH, Yim C, Kim S, Lee H, Kim H.

J Biol Chem. 2014 May 30;289(22):15845-55. doi: 10.1074/jbc.M113.533794. Epub 2014 Apr 21.

12.

Translocation of proteins through the Sec61 and SecYEG channels.

Mandon EC, Trueman SF, Gilmore R.

Curr Opin Cell Biol. 2009 Aug;21(4):501-7. doi: 10.1016/j.ceb.2009.04.010. Epub 2009 May 18. Review.

13.

Decatransin, a new natural product inhibiting protein translocation at the Sec61/SecYEG translocon.

Junne T, Wong J, Studer C, Aust T, Bauer BW, Beibel M, Bhullar B, Bruccoleri R, Eichenberger J, Estoppey D, Hartmann N, Knapp B, Krastel P, Melin N, Oakeley EJ, Oberer L, Riedl R, Roma G, Schuierer S, Petersen F, Tallarico JA, Rapoport TA, Spiess M, Hoepfner D.

J Cell Sci. 2015 Mar 15;128(6):1217-29. doi: 10.1242/jcs.165746. Epub 2015 Jan 22.

14.

The Get1/2 transmembrane complex is an endoplasmic-reticulum membrane protein insertase.

Wang F, Chan C, Weir NR, Denic V.

Nature. 2014 Aug 28;512(7515):441-4. doi: 10.1038/nature13471. Epub 2014 Jul 20.

15.

Apratoxin Kills Cells by Direct Blockade of the Sec61 Protein Translocation Channel.

Paatero AO, Kellosalo J, Dunyak BM, Almaliti J, Gestwicki JE, Gerwick WH, Taunton J, Paavilainen VO.

Cell Chem Biol. 2016 May 19;23(5):561-6. doi: 10.1016/j.chembiol.2016.04.008.

PMID:
27203376
16.
18.

Targeting HER3 by interfering with its Sec61-mediated cotranslational insertion into the endoplasmic reticulum.

Ruiz-Saenz A, Sandhu M, Carrasco Y, Maglathlin RL, Taunton J, Moasser MM.

Oncogene. 2015 Oct 8;34(41):5288-94. doi: 10.1038/onc.2014.455. Epub 2015 Jan 26.

19.

Defining a conformational consensus motif in cotransin-sensitive signal sequences: a proteomic and site-directed mutagenesis study.

Klein W, Westendorf C, Schmidt A, Conill-Cortés M, Rutz C, Blohs M, Beyermann M, Protze J, Krause G, Krause E, Schülein R.

PLoS One. 2015 Mar 25;10(3):e0120886. doi: 10.1371/journal.pone.0120886. eCollection 2015.

20.

Co-chaperone Specificity in Gating of the Polypeptide Conducting Channel in the Membrane of the Human Endoplasmic Reticulum.

Schorr S, Klein MC, Gamayun I, Melnyk A, Jung M, Schäuble N, Wang Q, Hemmis B, Bochen F, Greiner M, Lampel P, Urban SK, Hassdenteufel S, Dudek J, Chen XZ, Wagner R, Cavalié A, Zimmermann R.

J Biol Chem. 2015 Jul 24;290(30):18621-35. doi: 10.1074/jbc.M115.636639. Epub 2015 Jun 17.

PMID:
26085089
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