Display Settings:

Format
Items per page
Sort by

Send to:

Choose Destination

Results: 1 to 20 of 103

1.

In silico derived small molecules bind the filovirus VP35 protein and inhibit its polymerase cofactor activity.

Brown CS, Lee MS, Leung DW, Wang T, Xu W, Luthra P, Anantpadma M, Shabman RS, Melito LM, MacMillan KS, Borek DM, Otwinowski Z, Ramanan P, Stubbs AJ, Peterson DS, Binning JM, Tonelli M, Olson MA, Davey RA, Ready JM, Basler CF, Amarasinghe GK.

J Mol Biol. 2014 May 15;426(10):2045-58. doi: 10.1016/j.jmb.2014.01.010. Epub 2014 Feb 1.

PMID:
24495995
[PubMed - indexed for MEDLINE]
2.

Development of RNA aptamers targeting Ebola virus VP35.

Binning JM, Wang T, Luthra P, Shabman RS, Borek DM, Liu G, Xu W, Leung DW, Basler CF, Amarasinghe GK.

Biochemistry. 2013 Nov 26;52(47):8406-19. doi: 10.1021/bi400704d. Epub 2013 Nov 14.

PMID:
24067086
[PubMed - indexed for MEDLINE]
3.

Basic residues within the ebolavirus VP35 protein are required for its viral polymerase cofactor function.

Prins KC, Binning JM, Shabman RS, Leung DW, Amarasinghe GK, Basler CF.

J Virol. 2010 Oct;84(20):10581-91. doi: 10.1128/JVI.00925-10. Epub 2010 Aug 4.

PMID:
20686031
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Mutations abrogating VP35 interaction with double-stranded RNA render Ebola virus avirulent in guinea pigs.

Prins KC, Delpeut S, Leung DW, Reynard O, Volchkova VA, Reid SP, Ramanan P, Cárdenas WB, Amarasinghe GK, Volchkov VE, Basler CF.

J Virol. 2010 Mar;84(6):3004-15. doi: 10.1128/JVI.02459-09. Epub 2010 Jan 13.

PMID:
20071589
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Structure of the Ebola VP35 interferon inhibitory domain.

Leung DW, Ginder ND, Fulton DB, Nix J, Basler CF, Honzatko RB, Amarasinghe GK.

Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):411-6. doi: 10.1073/pnas.0807854106. Epub 2009 Jan 2.

PMID:
19122151
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Structural and functional characterization of Reston Ebola virus VP35 interferon inhibitory domain.

Leung DW, Shabman RS, Farahbakhsh M, Prins KC, Borek DM, Wang T, Mühlberger E, Basler CF, Amarasinghe GK.

J Mol Biol. 2010 Jun 11;399(3):347-57. doi: 10.1016/j.jmb.2010.04.022. Epub 2010 Apr 24.

PMID:
20399790
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Structural basis for Marburg virus VP35-mediated immune evasion mechanisms.

Ramanan P, Edwards MR, Shabman RS, Leung DW, Endlich-Frazier AC, Borek DM, Otwinowski Z, Liu G, Huh J, Basler CF, Amarasinghe GK.

Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):20661-6. doi: 10.1073/pnas.1213559109. Epub 2012 Nov 26.

PMID:
23185024
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

DRBP76 associates with Ebola virus VP35 and suppresses viral polymerase function.

Shabman RS, Leung DW, Johnson J, Glennon N, Gulcicek EE, Stone KL, Leung L, Hensley L, Amarasinghe GK, Basler CF.

J Infect Dis. 2011 Nov;204 Suppl 3:S911-8. doi: 10.1093/infdis/jir343.

PMID:
21987769
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Structural basis for dsRNA recognition and interferon antagonism by Ebola VP35.

Leung DW, Prins KC, Borek DM, Farahbakhsh M, Tufariello JM, Ramanan P, Nix JC, Helgeson LA, Otwinowski Z, Honzatko RB, Basler CF, Amarasinghe GK.

Nat Struct Mol Biol. 2010 Feb;17(2):165-72. doi: 10.1038/nsmb.1765. Epub 2010 Jan 17.

PMID:
20081868
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Mutual antagonism between the Ebola virus VP35 protein and the RIG-I activator PACT determines infection outcome.

Luthra P, Ramanan P, Mire CE, Weisend C, Tsuda Y, Yen B, Liu G, Leung DW, Geisbert TW, Ebihara H, Amarasinghe GK, Basler CF.

Cell Host Microbe. 2013 Jul 17;14(1):74-84. doi: 10.1016/j.chom.2013.06.010.

PMID:
23870315
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Crystallization and preliminary X-ray analysis of Ebola VP35 interferon inhibitory domain mutant proteins.

Leung DW, Borek D, Farahbakhsh M, Ramanan P, Nix JC, Wang T, Prins KC, Otwinowski Z, Honzatko RB, Helgeson LA, Basler CF, Amarasinghe GK.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Jun 1;66(Pt 6):689-92. doi: 10.1107/S1744309110013266. Epub 2010 May 27.

PMID:
20516601
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

The L-VP35 and L-L interaction domains reside in the amino terminus of the Ebola virus L protein and are potential targets for antivirals.

Trunschke M, Conrad D, Enterlein S, Olejnik J, Brauburger K, Mühlberger E.

Virology. 2013 Jul 5;441(2):135-45. doi: 10.1016/j.virol.2013.03.013. Epub 2013 Apr 11.

PMID:
23582637
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Evasion of interferon responses by Ebola and Marburg viruses.

Basler CF, Amarasinghe GK.

J Interferon Cytokine Res. 2009 Sep;29(9):511-20. doi: 10.1089/jir.2009.0076. Review.

PMID:
19694547
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Ebolavirus VP35 is a multifunctional virulence factor.

Leung DW, Prins KC, Basler CF, Amarasinghe GK.

Virulence. 2010 Nov-Dec;1(6):526-31. Epub 2010 Nov 1.

PMID:
21178490
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Marburg virus VP35 can both fully coat the backbone and cap the ends of dsRNA for interferon antagonism.

Bale S, Julien JP, Bornholdt ZA, Kimberlin CR, Halfmann P, Zandonatti MA, Kunert J, Kroon GJ, Kawaoka Y, MacRae IJ, Wilson IA, Saphire EO.

PLoS Pathog. 2012 Sep;8(9):e1002916. doi: 10.1371/journal.ppat.1002916. Epub 2012 Sep 13.

PMID:
23028316
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

dsRNA binding characterization of full length recombinant wild type and mutants Zaire ebolavirus VP35.

Zinzula L, Esposito F, Pala D, Tramontano E.

Antiviral Res. 2012 Mar;93(3):354-63. doi: 10.1016/j.antiviral.2012.01.005. Epub 2012 Jan 25.

PMID:
22289166
[PubMed - indexed for MEDLINE]
17.

Homo-oligomerization of Marburgvirus VP35 is essential for its function in replication and transcription.

Möller P, Pariente N, Klenk HD, Becker S.

J Virol. 2005 Dec;79(23):14876-86.

PMID:
16282487
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Purification and functional characterization of the full length recombinant Ebola virus VP35 protein expressed in E. coli.

Zinzula L, Esposito F, Mühlberger E, Trunschke M, Conrad D, Piano D, Tramontano E.

Protein Expr Purif. 2009 Jul;66(1):113-9. doi: 10.1016/j.pep.2009.02.008. Epub 2009 Feb 20.

PMID:
19233284
[PubMed - indexed for MEDLINE]
19.

The VP35 protein of Ebola virus inhibits the antiviral effect mediated by double-stranded RNA-dependent protein kinase PKR.

Feng Z, Cerveny M, Yan Z, He B.

J Virol. 2007 Jan;81(1):182-92. Epub 2006 Oct 25.

PMID:
17065211
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

VP35 knockdown inhibits Ebola virus amplification and protects against lethal infection in mice.

Enterlein S, Warfield KL, Swenson DL, Stein DA, Smith JL, Gamble CS, Kroeker AD, Iversen PL, Bavari S, Mühlberger E.

Antimicrob Agents Chemother. 2006 Mar;50(3):984-93.

PMID:
16495261
[PubMed - indexed for MEDLINE]
Free PMC Article

Display Settings:

Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

Write to the Help Desk