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Items: 1 to 20 of 99

1.

Molecular rotors as conditionally fluorescent labels for rapid detection of biomolecular interactions.

Goh WL, Lee MY, Joseph TL, Quah ST, Brown CJ, Verma C, Brenner S, Ghadessy FJ, Teo YN.

J Am Chem Soc. 2014 Apr 30;136(17):6159-62. doi: 10.1021/ja413031h. Epub 2014 Feb 11.

PMID:
24494589
2.

Rapid screening of protein-protein interaction inhibitors using the protease exclusion assay.

Nirantar SR, Li X, Siau JW, Ghadessy FJ.

Biosens Bioelectron. 2014 Jun 15;56:250-7. doi: 10.1016/j.bios.2013.12.060. Epub 2014 Jan 17.

PMID:
24508816
3.

A fluorescent probe for imaging p53-MDM2 protein-protein interaction.

Liu Z, Miao Z, Li J, Fang K, Zhuang C, Du L, Sheng C, Li M.

Chem Biol Drug Des. 2015 Apr;85(4):411-7. doi: 10.1111/cbdd.12434. Epub 2014 Oct 10.

PMID:
25226874
4.

Fluorescence anisotropy of molecular rotors.

Levitt JA, Chung PH, Kuimova MK, Yahioglu G, Wang Y, Qu J, Suhling K.

Chemphyschem. 2011 Feb 25;12(3):662-72. doi: 10.1002/cphc.201000782. Epub 2011 Feb 15.

PMID:
21328515
5.

mRNA display selection of an optimized MDM2-binding peptide that potently inhibits MDM2-p53 interaction.

Shiheido H, Takashima H, Doi N, Yanagawa H.

PLoS One. 2011 Mar 15;6(3):e17898. doi: 10.1371/journal.pone.0017898.

6.

Affinity-based screening of MDM2/MDMX-p53 interaction inhibitors by chemical array: identification of novel peptidic inhibitors.

Noguchi T, Oishi S, Honda K, Kondoh Y, Saito T, Kubo T, Kaneda M, Ohno H, Osada H, Fujii N.

Bioorg Med Chem Lett. 2013 Jul 1;23(13):3802-5. doi: 10.1016/j.bmcl.2013.04.094. Epub 2013 May 15.

PMID:
23726030
7.

Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX.

Pazgier M, Liu M, Zou G, Yuan W, Li C, Li C, Li J, Monbo J, Zella D, Tarasov SG, Lu W.

Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4665-70. doi: 10.1073/pnas.0900947106. Epub 2009 Mar 2.

8.

A facile method to screen inhibitors of protein-protein interactions including MDM2-p53 displayed on T7 phage.

Ishi K, Sugawara F.

Biochem Pharmacol. 2008 May 1;75(9):1743-50. doi: 10.1016/j.bcp.2008.01.020. Epub 2008 Mar 10.

PMID:
18384755
9.

Tetra-substituted imidazoles as a new class of inhibitors of the p53-MDM2 interaction.

Vaupel A, Bold G, De Pover A, Stachyra-Valat T, Lisztwan JH, Kallen J, Masuya K, Furet P.

Bioorg Med Chem Lett. 2014 May 1;24(9):2110-4. doi: 10.1016/j.bmcl.2014.03.039. Epub 2014 Mar 22. Erratum in: Bioorg Med Chem Lett. 2015 Mar 15;25(6):1356. Hergovich-Lisztwan, Joanna [corrected to Lisztwan, Joanna Hergovich].

PMID:
24704029
10.

De novo designed library of linear helical peptides: an exploratory tool in the discovery of protein-protein interaction modulators.

Bonache MÁ, Balsera B, López-Méndez B, Millet O, Brancaccio D, Gómez-Monterrey I, Carotenuto A, Pavone LM, Reille-Seroussi M, Gagey-Eilstein N, Vidal M, de la Torre-Martinez R, Fernández-Carvajal A, Ferrer-Montiel A, García-López MT, Martín-Martínez M, de Vega MJ, González-Muñiz R.

ACS Comb Sci. 2014 May 12;16(5):250-8. doi: 10.1021/co500005x. Epub 2014 Apr 22.

PMID:
24725184
11.

Molecular recognition of p53 and MDM2 by USP7/HAUSP.

Sheng Y, Saridakis V, Sarkari F, Duan S, Wu T, Arrowsmith CH, Frappier L.

Nat Struct Mol Biol. 2006 Mar;13(3):285-91. Epub 2006 Feb 12.

PMID:
16474402
12.

Miniature protein inhibitors of the p53-hDM2 interaction.

Kritzer JA, Zutshi R, Cheah M, Ran FA, Webman R, Wongjirad TM, Schepartz A.

Chembiochem. 2006 Jan;7(1):29-31. No abstract available.

PMID:
16397877
13.

Targeting of p53 peptide analogues to anti-apoptotic Bcl-2 family proteins as revealed by NMR spectroscopy.

Shin JS, Ha JH, Chi SW.

Biochem Biophys Res Commun. 2014 Jan 17;443(3):882-7. doi: 10.1016/j.bbrc.2013.12.054. Epub 2013 Dec 14.

PMID:
24342622
14.

Conjugation of spermine enhances cellular uptake of the stapled peptide-based inhibitors of p53-Mdm2 interaction.

Muppidi A, Li X, Chen J, Lin Q.

Bioorg Med Chem Lett. 2011 Dec 15;21(24):7412-5. doi: 10.1016/j.bmcl.2011.10.009. Epub 2011 Oct 12.

15.
16.

Expansion of protein interaction maps by phage peptide display using MDM2 as a prototypical conformationally flexible target protein.

Burch L, Shimizu H, Smith A, Patterson C, Hupp TR.

J Mol Biol. 2004 Mar 12;337(1):129-45.

PMID:
15001357
17.

The fluorescent two-hybrid assay to screen for protein-protein interaction inhibitors in live cells: targeting the interaction of p53 with Mdm2 and Mdm4.

Yurlova L, Derks M, Buchfellner A, Hickson I, Janssen M, Morrison D, Stansfield I, Brown CJ, Ghadessy FJ, Lane DP, Rothbauer U, Zolghadr K, Krausz E.

J Biomol Screen. 2014 Apr;19(4):516-25. doi: 10.1177/1087057113518067. Epub 2014 Jan 29.

PMID:
24476585
18.

Discovery of novel dihydroimidazothiazole derivatives as p53-MDM2 protein-protein interaction inhibitors: synthesis, biological evaluation and structure-activity relationships.

Miyazaki M, Kawato H, Naito H, Ikeda M, Miyazaki M, Kitagawa M, Seki T, Fukutake S, Aonuma M, Soga T.

Bioorg Med Chem Lett. 2012 Oct 15;22(20):6338-42. doi: 10.1016/j.bmcl.2012.08.086. Epub 2012 Aug 30.

PMID:
22995624
19.

Fragment-based library generation for the discovery of a peptidomimetic p53-Mdm4 inhibitor.

Boltjes A, Huang Y, van de Velde R, Rijkee L, Wolf S, Gaugler J, Lesniak K, Guzik K, Holak TA, Dömling A.

ACS Comb Sci. 2014 Aug 11;16(8):393-6. doi: 10.1021/co500026b. Epub 2014 Jul 11.

20.

Analysis of chemical shift changes reveals the binding modes of isoindolinone inhibitors of the MDM2-p53 interaction.

Riedinger C, Endicott JA, Kemp SJ, Smyth LA, Watson A, Valeur E, Golding BT, Griffin RJ, Hardcastle IR, Noble ME, McDonnell JM.

J Am Chem Soc. 2008 Nov 26;130(47):16038-44. doi: 10.1021/ja8062088.

PMID:
18959403
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