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Pharmacological rescue of Ras signaling, GluA1-dependent synaptic plasticity, and learning deficits in a fragile X model.

Lim CS, Hoang ET, Viar KE, Stornetta RL, Scott MM, Zhu JJ.

Genes Dev. 2014 Feb 1;28(3):273-89. doi: 10.1101/gad.232470.113.


Ras signaling mechanisms underlying impaired GluR1-dependent plasticity associated with fragile X syndrome.

Hu H, Qin Y, Bochorishvili G, Zhu Y, van Aelst L, Zhu JJ.

J Neurosci. 2008 Jul 30;28(31):7847-62. doi: 10.1523/JNEUROSCI.1496-08.2008.


Altered structural and functional synaptic plasticity with motor skill learning in a mouse model of fragile X syndrome.

Padmashri R, Reiner BC, Suresh A, Spartz E, Dunaevsky A.

J Neurosci. 2013 Dec 11;33(50):19715-23. doi: 10.1523/JNEUROSCI.2514-13.2013.


Reversal of disease-related pathologies in the fragile X mouse model by selective activation of GABAB receptors with arbaclofen.

Henderson C, Wijetunge L, Kinoshita MN, Shumway M, Hammond RS, Postma FR, Brynczka C, Rush R, Thomas A, Paylor R, Warren ST, Vanderklish PW, Kind PC, Carpenter RL, Bear MF, Healy AM.

Sci Transl Med. 2012 Sep 19;4(152):152ra128.


Deficits in LTP induction by 5-HT2A receptor antagonist in a mouse model for fragile X syndrome.

Xu ZH, Yang Q, Ma L, Liu SB, Chen GS, Wu YM, Li XQ, Liu G, Zhao MG.

PLoS One. 2012;7(10):e48741. doi: 10.1371/journal.pone.0048741. Epub 2012 Oct 31.


Characterization and reversal of synaptic defects in the amygdala in a mouse model of fragile X syndrome.

Suvrathan A, Hoeffer CA, Wong H, Klann E, Chattarji S.

Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11591-6. doi: 10.1073/pnas.1002262107. Epub 2010 Jun 7.


Dysregulation of mTOR signaling in fragile X syndrome.

Sharma A, Hoeffer CA, Takayasu Y, Miyawaki T, McBride SM, Klann E, Zukin RS.

J Neurosci. 2010 Jan 13;30(2):694-702. doi: 10.1523/JNEUROSCI.3696-09.2010.


Fragile X mental retardation protein deficiency leads to excessive mGluR5-dependent internalization of AMPA receptors.

Nakamoto M, Nalavadi V, Epstein MP, Narayanan U, Bassell GJ, Warren ST.

Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15537-42. Epub 2007 Sep 19.


Protective effects of melatonin against oxidative stress in Fmr1 knockout mice: a therapeutic research model for the fragile X syndrome.

Romero-Zerbo Y, Decara J, el Bekay R, Sanchez-Salido L, Del Arco-Herrera I, de Fonseca FR, de Diego-Otero Y.

J Pineal Res. 2009 Mar;46(2):224-34. doi: 10.1111/j.1600-079X.2008.00653.x. Epub 2008 Dec 23.


Activation of 5-HT7 serotonin receptors reverses metabotropic glutamate receptor-mediated synaptic plasticity in wild-type and Fmr1 knockout mice, a model of Fragile X syndrome.

Costa L, Spatuzza M, D'Antoni S, Bonaccorso CM, Trovato C, Musumeci SA, Leopoldo M, Lacivita E, Catania MV, Ciranna L.

Biol Psychiatry. 2012 Dec 1;72(11):924-33. doi: 10.1016/j.biopsych.2012.06.008. Epub 2012 Jul 18.


Reduced cortical synaptic plasticity and GluR1 expression associated with fragile X mental retardation protein deficiency.

Li J, Pelletier MR, Perez Velazquez JL, Carlen PL.

Mol Cell Neurosci. 2002 Feb;19(2):138-51.


Altered hippocampal synaptic plasticity in the FMR1 gene family knockout mouse models.

Zhang J, Hou L, Klann E, Nelson DL.

J Neurophysiol. 2009 May;101(5):2572-80. doi: 10.1152/jn.90558.2008. Epub 2009 Feb 25.


The fragile X-cerebellum connection.

Huber KM.

Trends Neurosci. 2006 Apr;29(4):183-5. Epub 2006 Feb 28. Review.


7, 8-Dihydroxyflavone induces synapse expression of AMPA GluA1 and ameliorates cognitive and spine abnormalities in a mouse model of fragile X syndrome.

Tian M, Zeng Y, Hu Y, Yuan X, Liu S, Li J, Lu P, Sun Y, Gao L, Fu D, Li Y, Wang S, McClintock SM.

Neuropharmacology. 2015 Feb;89:43-53. doi: 10.1016/j.neuropharm.2014.09.006. Epub 2014 Sep 16.


Modulation of dendritic spines and synaptic function by Rac1: a possible link to Fragile X syndrome pathology.

Bongmba OY, Martinez LA, Elhardt ME, Butler K, Tejada-Simon MV.

Brain Res. 2011 Jul 5;1399:79-95. doi: 10.1016/j.brainres.2011.05.020. Epub 2011 May 17. Erratum in: Brain Res. 2011 Nov 14;1423:114-5.


Synaptic ionotropic glutamate receptors and plasticity are developmentally altered in the CA1 field of Fmr1 knockout mice.

Pilpel Y, Kolleker A, Berberich S, Ginger M, Frick A, Mientjes E, Oostra BA, Seeburg PH.

J Physiol. 2009 Feb 15;587(Pt 4):787-804. doi: 10.1113/jphysiol.2008.160929. Epub 2008 Dec 22.


Comprehensive analysis of ultrasonic vocalizations in a mouse model of fragile X syndrome reveals limited, call type specific deficits.

Roy S, Watkins N, Heck D.

PLoS One. 2012;7(9):e44816. doi: 10.1371/journal.pone.0044816. Epub 2012 Sep 11.


A reduced number of metabotropic glutamate subtype 5 receptors are associated with constitutive homer proteins in a mouse model of fragile X syndrome.

Giuffrida R, Musumeci S, D'Antoni S, Bonaccorso CM, Giuffrida-Stella AM, Oostra BA, Catania MV.

J Neurosci. 2005 Sep 28;25(39):8908-16.

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