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Results: 1 to 20 of 100

1.

Oncogenic transformation of mesenchymal stem cells decreases Nrf2 expression favoring in vivo tumor growth and poorer survival.

Funes JM, Henderson S, Kaufman R, Flanagan JM, Robson M, Pedley B, Moncada S, Boshoff C.

Mol Cancer. 2014 Feb 3;13:20. doi: 10.1186/1476-4598-13-20.

PMID:
24491031
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis.

DeNicola GM, Karreth FA, Humpton TJ, Gopinathan A, Wei C, Frese K, Mangal D, Yu KH, Yeo CJ, Calhoun ES, Scrimieri F, Winter JM, Hruban RH, Iacobuzio-Donahue C, Kern SE, Blair IA, Tuveson DA.

Nature. 2011 Jul 6;475(7354):106-9. doi: 10.1038/nature10189.

PMID:
21734707
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival.

Gorrini C, Baniasadi PS, Harris IS, Silvester J, Inoue S, Snow B, Joshi PA, Wakeham A, Molyneux SD, Martin B, Bouwman P, Cescon DW, Elia AJ, Winterton-Perks Z, Cruickshank J, Brenner D, Tseng A, Musgrave M, Berman HK, Khokha R, Jonkers J, Mak TW, Gauthier ML.

J Exp Med. 2013 Jul 29;210(8):1529-44. doi: 10.1084/jem.20121337. Epub 2013 Jul 15.

PMID:
23857982
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress.

Nguyen T, Nioi P, Pickett CB.

J Biol Chem. 2009 May 15;284(20):13291-5. doi: 10.1074/jbc.R900010200. Epub 2009 Jan 30. Review.

PMID:
19182219
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

NRF2 inhibition represses ErbB2 signaling in ovarian carcinoma cells: implications for tumor growth retardation and docetaxel sensitivity.

Manandhar S, Choi BH, Jung KA, Ryoo IG, Song M, Kang SJ, Choi HG, Kim JA, Park PH, Kwak MK.

Free Radic Biol Med. 2012 May 1;52(9):1773-85. doi: 10.1016/j.freeradbiomed.2012.02.031. Epub 2012 Mar 3.

PMID:
22387177
[PubMed - indexed for MEDLINE]
6.

TDAG51 is an ERK signaling target that opposes ERK-mediated HME16C mammary epithelial cell transformation.

Oberst MD, Beberman SJ, Zhao L, Yin JJ, Ward Y, Kelly K.

BMC Cancer. 2008 Jul 2;8:189. doi: 10.1186/1471-2407-8-189.

PMID:
18597688
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Global downstream pathway analysis reveals a dependence of oncogenic NF-E2-related factor 2 mutation on the mTOR growth signaling pathway.

Shibata T, Saito S, Kokubu A, Suzuki T, Yamamoto M, Hirohashi S.

Cancer Res. 2010 Nov 15;70(22):9095-105. doi: 10.1158/0008-5472.CAN-10-0384. Epub 2010 Nov 9.

PMID:
21062981
[PubMed - indexed for MEDLINE]
Free Article
8.

Sulforaphane decreases endothelial cell apoptosis in fuchs endothelial corneal dystrophy: a novel treatment.

Ziaei A, Schmedt T, Chen Y, Jurkunas UV.

Invest Ophthalmol Vis Sci. 2013 Oct 15;54(10):6724-34. doi: 10.1167/iovs.13-12699.

PMID:
24030461
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Chemoprevention of dietary digitoflavone on colitis-associated colon tumorigenesis through inducing Nrf2 signaling pathway and inhibition of inflammation.

Yang Y, Cai X, Yang J, Sun X, Hu C, Yan Z, Xu X, Lu W, Wang X, Cao P.

Mol Cancer. 2014 Mar 6;13:48. doi: 10.1186/1476-4598-13-48.

PMID:
24602443
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Adaphostin toxicity in a sensitive non-small cell lung cancer model is mediated through Nrf2 signaling and heme oxygenase 1.

Fer ND, Shoemaker RH, Monks A.

J Exp Clin Cancer Res. 2010 Jul 9;29:91. doi: 10.1186/1756-9966-29-91.

PMID:
20618971
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

The role of Nrf2 in increased reactive oxygen species and DNA damage in prostate tumorigenesis.

Frohlich DA, McCabe MT, Arnold RS, Day ML.

Oncogene. 2008 Jul 17;27(31):4353-62. doi: 10.1038/onc.2008.79. Epub 2008 Mar 31.

PMID:
18372916
[PubMed - indexed for MEDLINE]
12.

Dietary phytochemicals and cancer prevention: Nrf2 signaling, epigenetics, and cell death mechanisms in blocking cancer initiation and progression.

Lee JH, Khor TO, Shu L, Su ZY, Fuentes F, Kong AN.

Pharmacol Ther. 2013 Feb;137(2):153-71. doi: 10.1016/j.pharmthera.2012.09.008. Epub 2012 Oct 3. Review.

PMID:
23041058
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Transcription factor NRF2 regulates miR-1 and miR-206 to drive tumorigenesis.

Singh A, Happel C, Manna SK, Acquaah-Mensah G, Carrerero J, Kumar S, Nasipuri P, Krausz KW, Wakabayashi N, Dewi R, Boros LG, Gonzalez FJ, Gabrielson E, Wong KK, Girnun G, Biswal S.

J Clin Invest. 2013 Jul 1;123(7):2921-34. doi: 10.1172/JCI66353. Epub 2013 Jun 10.

PMID:
23921124
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Nrf2 knockout enhances intestinal tumorigenesis in Apc(min/+) mice due to attenuation of anti-oxidative stress pathway while potentiates inflammation.

Cheung KL, Lee JH, Khor TO, Wu TY, Li GX, Chan J, Yang CS, Kong AN.

Mol Carcinog. 2014 Jan;53(1):77-84. doi: 10.1002/mc.21950. Epub 2012 Aug 21.

PMID:
22911891
[PubMed - indexed for MEDLINE]
15.

Antioxidant-mediated up-regulation of OGG1 via NRF2 induction is associated with inhibition of oxidative DNA damage in estrogen-induced breast cancer.

Singh B, Chatterjee A, Ronghe AM, Bhat NK, Bhat HK.

BMC Cancer. 2013 May 22;13:253. doi: 10.1186/1471-2407-13-253.

PMID:
23697596
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Roles of the RAF/MEK/ERK and PI3K/PTEN/AKT pathways in malignant transformation and drug resistance.

McCubrey JA, Steelman LS, Abrams SL, Lee JT, Chang F, Bertrand FE, Navolanic PM, Terrian DM, Franklin RA, D'Assoro AB, Salisbury JL, Mazzarino MC, Stivala F, Libra M.

Adv Enzyme Regul. 2006;46:249-79. Epub 2006 Jul 18.

PMID:
16854453
[PubMed - indexed for MEDLINE]
17.

Differential response of DU145 and PC3 prostate cancer cells to ionizing radiation: role of reactive oxygen species, GSH and Nrf2 in radiosensitivity.

Jayakumar S, Kunwar A, Sandur SK, Pandey BN, Chaubey RC.

Biochim Biophys Acta. 2014 Jan;1840(1):485-94. doi: 10.1016/j.bbagen.2013.10.006. Epub 2013 Oct 9.

PMID:
24121106
[PubMed - indexed for MEDLINE]
18.

Estrogen controls the survival of BRCA1-deficient cells via a PI3K-NRF2-regulated pathway.

Gorrini C, Gang BP, Bassi C, Wakeham A, Baniasadi SP, Hao Z, Li WY, Cescon DW, Li YT, Molyneux S, Penrod N, Lupien M, Schmidt EE, Stambolic V, Gauthier ML, Mak TW.

Proc Natl Acad Sci U S A. 2014 Mar 25;111(12):4472-7. doi: 10.1073/pnas.1324136111. Epub 2014 Feb 24.

PMID:
24567396
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

An effective strategy for increasing the radiosensitivity of Human lung Cancer cells by blocking Nrf2-dependent antioxidant responses.

Lee S, Lim MJ, Kim MH, Yu CH, Yun YS, Ahn J, Song JY.

Free Radic Biol Med. 2012 Aug 15;53(4):807-16. doi: 10.1016/j.freeradbiomed.2012.05.038. Epub 2012 Jun 7.

PMID:
22684019
[PubMed - indexed for MEDLINE]
20.

HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response.

Rotblat B, Southwell AL, Ehrnhoefer DE, Skotte NH, Metzler M, Franciosi S, Leprivier G, Somasekharan SP, Barokas A, Deng Y, Tang T, Mathers J, Cetinbas N, Daugaard M, Kwok B, Li L, Carnie CJ, Fink D, Nitsch R, Galpin JD, Ahern CA, Melino G, Penninger JM, Hayden MR, Sorensen PH.

Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3032-7. doi: 10.1073/pnas.1314421111. Epub 2014 Feb 10.

PMID:
24516159
[PubMed - indexed for MEDLINE]
Free PMC Article

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