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Results: 1 to 20 of 160

1.

Keap1 cysteine 288 as a potential target for diallyl trisulfide-induced Nrf2 activation.

Kim S, Lee HG, Park SA, Kundu JK, Keum YS, Cha YN, Na HK, Surh YJ.

PLoS One. 2014 Jan 28;9(1):e85984. doi: 10.1371/journal.pone.0085984. eCollection 2014.

PMID:
24489685
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Antioxidant effects of diallyl trisulfide on high glucose-induced apoptosis are mediated by the PI3K/Akt-dependent activation of Nrf2 in cardiomyocytes.

Tsai CY, Wang CC, Lai TY, Tsu HN, Wang CH, Liang HY, Kuo WW.

Int J Cardiol. 2013 Sep 30;168(2):1286-97. doi: 10.1016/j.ijcard.2012.12.004. Epub 2013 Feb 27.

PMID:
23453443
[PubMed - indexed for MEDLINE]
3.

Induction of detoxifying enzymes by garlic organosulfur compounds through transcription factor Nrf2: effect of chemical structure and stress signals.

Chen C, Pung D, Leong V, Hebbar V, Shen G, Nair S, Li W, Kong AN.

Free Radic Biol Med. 2004 Nov 15;37(10):1578-90.

PMID:
15477009
[PubMed - indexed for MEDLINE]
4.

Induction of drug-metabolizing enzymes by garlic and allyl sulfide compounds via activation of constitutive androstane receptor and nuclear factor E2-related factor 2.

Fisher CD, Augustine LM, Maher JM, Nelson DM, Slitt AL, Klaassen CD, Lehman-McKeeman LD, Cherrington NJ.

Drug Metab Dispos. 2007 Jun;35(6):995-1000. Epub 2007 Mar 12.

PMID:
17353348
[PubMed - indexed for MEDLINE]
Free Article
5.

Critical cysteine residues of Kelch-like ECH-associated protein 1 in arsenic sensing and suppression of nuclear factor erythroid 2-related factor 2.

He X, Ma Q.

J Pharmacol Exp Ther. 2010 Jan;332(1):66-75. doi: 10.1124/jpet.109.160465. Epub 2009 Oct 6.

PMID:
19808700
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Altered disposition of acetaminophen in Nrf2-null and Keap1-knockdown mice.

Reisman SA, Csanaky IL, Aleksunes LM, Klaassen CD.

Toxicol Sci. 2009 May;109(1):31-40. doi: 10.1093/toxsci/kfp047. Epub 2009 Feb 26.

PMID:
19246624
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Inhibitory effects and molecular mechanisms of garlic organosulfur compounds on the production of inflammatory mediators.

You S, Nakanishi E, Kuwata H, Chen J, Nakasone Y, He X, He J, Liu X, Zhang S, Zhang B, Hou DX.

Mol Nutr Food Res. 2013 Nov;57(11):2049-60. doi: 10.1002/mnfr.201200843. Epub 2013 Jun 14.

PMID:
23766070
[PubMed - indexed for MEDLINE]
8.

Increased Nrf2 activation in livers from Keap1-knockdown mice increases expression of cytoprotective genes that detoxify electrophiles more than those that detoxify reactive oxygen species.

Reisman SA, Yeager RL, Yamamoto M, Klaassen CD.

Toxicol Sci. 2009 Mar;108(1):35-47. doi: 10.1093/toxsci/kfn267. Epub 2009 Jan 6.

PMID:
19129213
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Piceatannol induces heme oxygenase-1 expression in human mammary epithelial cells through activation of ARE-driven Nrf2 signaling.

Lee HH, Park SA, Almazari I, Kim EH, Na HK, Surh YJ.

Arch Biochem Biophys. 2010 Sep 1;501(1):142-50. doi: 10.1016/j.abb.2010.06.011. Epub 2010 Jun 15.

PMID:
20558128
[PubMed - indexed for MEDLINE]
10.

The hepatotoxic metabolite of acetaminophen directly activates the Keap1-Nrf2 cell defense system.

Copple IM, Goldring CE, Jenkins RE, Chia AJ, Randle LE, Hayes JD, Kitteringham NR, Park BK.

Hepatology. 2008 Oct;48(4):1292-301. doi: 10.1002/hep.22472.

PMID:
18785192
[PubMed - indexed for MEDLINE]
11.

Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity.

Yamamoto T, Suzuki T, Kobayashi A, Wakabayashi J, Maher J, Motohashi H, Yamamoto M.

Mol Cell Biol. 2008 Apr;28(8):2758-70. doi: 10.1128/MCB.01704-07. Epub 2008 Feb 11.

PMID:
18268004
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

NAD(P)H:quinone oxidoreductase 1 activity reduces hypertrophy in 3T3-L1 adipocytes.

Vomhof-DeKrey EE, Picklo MJ.

Free Radic Biol Med. 2012 Aug 15;53(4):690-700. doi: 10.1016/j.freeradbiomed.2012.05.047. Epub 2012 Jun 8.

PMID:
22683604
[PubMed - indexed for MEDLINE]
13.

The involvement of Nrf2 in the protective effects of diallyl disulfide on carbon tetrachloride-induced hepatic oxidative damage and inflammatory response in rats.

Lee IC, Kim SH, Baek HS, Moon C, Kang SS, Kim SH, Kim YB, Shin IS, Kim JC.

Food Chem Toxicol. 2014 Jan;63:174-85. doi: 10.1016/j.fct.2013.11.006. Epub 2013 Nov 15.

PMID:
24246655
[PubMed - indexed for MEDLINE]
14.

Diallyl trisulfide induces apoptosis in human breast cancer cells through ROS-mediated activation of JNK and AP-1.

Na HK, Kim EH, Choi MA, Park JM, Kim DH, Surh YJ.

Biochem Pharmacol. 2012 Nov 15;84(10):1241-50. doi: 10.1016/j.bcp.2012.08.024. Epub 2012 Sep 6.

PMID:
22981381
[PubMed - indexed for MEDLINE]
15.

Neuroprotective potential of phase II enzyme inducer diallyl trisulfide.

Sun MM, Bu H, Li B, Yu JX, Guo YS, Li CY.

Neurol Res. 2009 Feb;31(1):23-7. doi: 10.1179/174313208X332959. Epub 2008 Sep 3.

PMID:
18768114
[PubMed - indexed for MEDLINE]
16.

Diallyl trisulfide suppresses the proliferation and induces apoptosis of human colon cancer cells through oxidative modification of beta-tubulin.

Hosono T, Fukao T, Ogihara J, Ito Y, Shiba H, Seki T, Ariga T.

J Biol Chem. 2005 Dec 16;280(50):41487-93. Epub 2005 Oct 11.

PMID:
16219763
[PubMed - indexed for MEDLINE]
Free Article
17.

Arsenic induces NAD(P)H-quinone oxidoreductase I by disrupting the Nrf2 x Keap1 x Cul3 complex and recruiting Nrf2 x Maf to the antioxidant response element enhancer.

He X, Chen MG, Lin GX, Ma Q.

J Biol Chem. 2006 Aug 18;281(33):23620-31. Epub 2006 Jun 19.

PMID:
16785233
[PubMed - indexed for MEDLINE]
Free Article
18.

Validation of the multiple sensor mechanism of the Keap1-Nrf2 system.

Takaya K, Suzuki T, Motohashi H, Onodera K, Satomi S, Kensler TW, Yamamoto M.

Free Radic Biol Med. 2012 Aug 15;53(4):817-27. doi: 10.1016/j.freeradbiomed.2012.06.023. Epub 2012 Jun 23.

PMID:
22732183
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Constitutive activation of nuclear factor-E2-related factor 2 induces biotransformation enzyme and transporter expression in livers of mice with hepatocyte-specific deletion of Kelch-like ECH-associated protein 1.

Cheng Q, Taguchi K, Aleksunes LM, Manautou JE, Cherrington NJ, Yamamoto M, Slitt AL.

J Biochem Mol Toxicol. 2011 Sep-Oct;25(5):320-9. doi: 10.1002/jbt.20392. Epub 2011 May 2.

PMID:
21538727
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

The Keap1/Nrf2 protein axis plays a role in osteoclast differentiation by regulating intracellular reactive oxygen species signaling.

Kanzaki H, Shinohara F, Kajiya M, Kodama T.

J Biol Chem. 2013 Aug 9;288(32):23009-20. doi: 10.1074/jbc.M113.478545. Epub 2013 Jun 25. Erratum in: J Biol Chem. 2014 Feb 28;289(9):5536.

PMID:
23801334
[PubMed - indexed for MEDLINE]
Free PMC Article

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