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Results: 1 to 20 of 122

1.

[Design, synthesis and evaluation of bis-nicotine derivatives as inhibitors of cholinesterases and beta-amyloid aggregation].

Luo W, Zhao YM, Tian RG, Su YB, Hong C.

Yao Xue Xue Bao. 2013 Nov;48(11):1671-6. Chinese.

PMID:
24475704
[PubMed - in process]
2.

Design, synthesis and evaluation of novel 4-dimethylamine flavonoid derivatives as potential multi-functional anti-Alzheimer agents.

Luo W, Su YB, Hong C, Tian RG, Su LP, Wang YQ, Li Y, Yue JJ, Wang CJ.

Bioorg Med Chem. 2013 Dec 1;21(23):7275-82. doi: 10.1016/j.bmc.2013.09.061. Epub 2013 Oct 4.

PMID:
24148835
[PubMed - indexed for MEDLINE]
3.

Design, synthesis and evaluation of novel tacrine-multialkoxybenzene hybrids as dual inhibitors for cholinesterases and amyloid beta aggregation.

Luo W, Li YP, He Y, Huang SL, Tan JH, Ou TM, Li D, Gu LQ, Huang ZS.

Bioorg Med Chem. 2011 Jan 15;19(2):763-70. doi: 10.1016/j.bmc.2010.12.022. Epub 2010 Dec 13.

PMID:
21211982
[PubMed - indexed for MEDLINE]
4.

Synthesis and evaluation of heterobivalent tacrine derivatives as potential multi-functional anti-Alzheimer agents.

Luo W, Li YP, He Y, Huang SL, Li D, Gu LQ, Huang ZS.

Eur J Med Chem. 2011 Jun;46(6):2609-16. doi: 10.1016/j.ejmech.2011.03.058. Epub 2011 Apr 3.

PMID:
21497959
[PubMed - indexed for MEDLINE]
5.

[Design, synthesis and cholinesterase inhibitory activity of quinoline-polyamine conjugates].

Luo W, Huang K, Zhang Z, Hong C, Wang CJ.

Yao Xue Xue Bao. 2013 Feb;48(2):269-75. Chinese.

PMID:
23672025
[PubMed - indexed for MEDLINE]
6.

Synthesis, in vitro assay, and molecular modeling of new piperidine derivatives having dual inhibitory potency against acetylcholinesterase and Abeta1-42 aggregation for Alzheimer's disease therapeutics.

Kwon YE, Park JY, No KT, Shin JH, Lee SK, Eun JS, Yang JH, Shin TY, Kim DK, Chae BS, Leem JY, Kim KH.

Bioorg Med Chem. 2007 Oct 15;15(20):6596-607. Epub 2007 Jul 25.

PMID:
17681794
[PubMed - indexed for MEDLINE]
7.

Novel aromatic-polyamine conjugates as cholinesterase inhibitors with notable selectivity toward butyrylcholinesterase.

Hong C, Luo W, Yao D, Su YB, Zhang X, Tian RG, Wang CJ.

Bioorg Med Chem. 2014 Jun 15;22(12):3213-9. doi: 10.1016/j.bmc.2014.03.045. Epub 2014 Apr 13.

PMID:
24794747
[PubMed - in process]
8.

Synthesis and evaluation of 7,8-dehydrorutaecarpine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.

He Y, Yao PF, Chen SB, Huang ZH, Huang SL, Tan JH, Li D, Gu LQ, Huang ZS.

Eur J Med Chem. 2013 May;63:299-312. doi: 10.1016/j.ejmech.2013.02.014. Epub 2013 Feb 26.

PMID:
23501115
[PubMed - indexed for MEDLINE]
9.

Design, synthesis, and biological evaluation of conformationally restricted rivastigmine analogues.

Bolognesi ML, Bartolini M, Cavalli A, Andrisano V, Rosini M, Minarini A, Melchiorre C.

J Med Chem. 2004 Nov 18;47(24):5945-52.

PMID:
15537349
[PubMed - indexed for MEDLINE]
10.

7-MEOTA-donepezil like compounds as cholinesterase inhibitors: Synthesis, pharmacological evaluation, molecular modeling and QSAR studies.

Korabecny J, Dolezal R, Cabelova P, Horova A, Hruba E, Ricny J, Sedlacek L, Nepovimova E, Spilovska K, Andrs M, Musilek K, Opletalova V, Sepsova V, Ripova D, Kuca K.

Eur J Med Chem. 2014 Jul 23;82:426-38. doi: 10.1016/j.ejmech.2014.05.066. Epub 2014 May 27.

PMID:
24929293
[PubMed - in process]
11.

Design, synthesis and evaluation of novel 2-(aminoalkyl)-isoindoline-1,3-dione derivatives as dual-binding site acetylcholinesterase inhibitors.

Ignasik M, Bajda M, Guzior N, Prinz M, Holzgrabe U, Malawska B.

Arch Pharm (Weinheim). 2012 Jul;345(7):509-16. doi: 10.1002/ardp.201100423. Epub 2012 Mar 30.

PMID:
22467516
[PubMed - indexed for MEDLINE]
12.

Synthesis and biological evaluation of novel N,N'-bis-methylenedioxybenzyl-alkylenediamines as bivalent anti-Alzheimer disease ligands.

Luo W, Li YP, Tan JH, Gu LQ, Huang ZS.

J Enzyme Inhib Med Chem. 2011 Oct;26(5):706-11. doi: 10.3109/14756366.2010.548329. Epub 2011 Jan 21.

PMID:
21250822
[PubMed - indexed for MEDLINE]
13.

Design, synthesis and evaluation of genistein-O-alkylbenzylamines as potential multifunctional agents for the treatment of Alzheimer's disease.

Qiang X, Sang Z, Yuan W, Li Y, Liu Q, Bai P, Shi Y, Ang W, Tan Z, Deng Y.

Eur J Med Chem. 2014 Apr 9;76:314-31. doi: 10.1016/j.ejmech.2014.02.045. Epub 2014 Feb 17.

PMID:
24589487
[PubMed - in process]
14.

Benzophenone-based derivatives: a novel series of potent and selective dual inhibitors of acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.

Belluti F, Bartolini M, Bottegoni G, Bisi A, Cavalli A, Andrisano V, Rampa A.

Eur J Med Chem. 2011 May;46(5):1682-93. doi: 10.1016/j.ejmech.2011.02.019. Epub 2011 Feb 22.

PMID:
21397996
[PubMed - indexed for MEDLINE]
15.

Synthesis, biological evaluation and molecular modeling study of novel tacrine-carbazole hybrids as potential multifunctional agents for the treatment of Alzheimer's disease.

Thiratmatrakul S, Yenjai C, Waiwut P, Vajragupta O, Reubroycharoen P, Tohda M, Boonyarat C.

Eur J Med Chem. 2014 Mar 21;75:21-30. doi: 10.1016/j.ejmech.2014.01.020. Epub 2014 Jan 22.

PMID:
24508831
[PubMed - in process]
16.

Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.

Brunhofer G, Fallarero A, Karlsson D, Batista-Gonzalez A, Shinde P, Gopi Mohan C, Vuorela P.

Bioorg Med Chem. 2012 Nov 15;20(22):6669-79. doi: 10.1016/j.bmc.2012.09.040. Epub 2012 Sep 26.

PMID:
23062825
[PubMed - indexed for MEDLINE]
17.

Synthesis, biological evaluation, and molecular modeling of berberine derivatives as potent acetylcholinesterase inhibitors.

Huang L, Shi A, He F, Li X.

Bioorg Med Chem. 2010 Feb;18(3):1244-51. doi: 10.1016/j.bmc.2009.12.035. Epub 2009 Dec 16.

PMID:
20056426
[PubMed - indexed for MEDLINE]
18.

Design, synthesis and evaluation of flavonoid derivatives as potential multifunctional acetylcholinesterase inhibitors against Alzheimer's disease.

Li RS, Wang XB, Hu XJ, Kong LY.

Bioorg Med Chem Lett. 2013 May 1;23(9):2636-41. doi: 10.1016/j.bmcl.2013.02.095. Epub 2013 Mar 1.

PMID:
23511019
[PubMed - indexed for MEDLINE]
19.

Pharmacological Evaluation and Docking Studies of 3-Thiadiazolyl- and Thioxo-1,2,4-triazolylcoumarin Derivatives as Cholinesterase Inhibitors.

Raza A, Saeed A, Ibrar A, Muddassar M, Khan AA, Iqbal J.

ISRN Pharmacol. 2012;2012:707932. doi: 10.5402/2012/707932. Epub 2012 Aug 16.

PMID:
22966467
[PubMed]
Free PMC Article
20.

[Design, synthesis and evaluation of tacrine-methoxybenzene hybrids as cholinesterases inhibitors].

Luo W, Zhao YM, Zhang Z, Su YB, Wang CJ.

Yao Xue Xue Bao. 2012 Jul;47(7):916-21. Chinese.

PMID:
22993857
[PubMed - indexed for MEDLINE]

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