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Results: 1 to 20 of 93

1.

Loss of Bak enhances lymphocytosis but does not ameliorate thrombocytopaenia in BCL-2 transgenic mice.

Vandenberg CJ, Josefsson EC, Campbell KJ, James C, Lawlor KE, Kile BT, Cory S.

Cell Death Differ. 2014 May;21(5):676-84. doi: 10.1038/cdd.2013.201. Epub 2014 Jan 24.

PMID:
24464220
[PubMed - in process]
Free PMC Article
2.

Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation.

Chen S, Dai Y, Harada H, Dent P, Grant S.

Cancer Res. 2007 Jan 15;67(2):782-91.

PMID:
17234790
[PubMed - indexed for MEDLINE]
Free Article
3.

Elevated Mcl-1 inhibits thymocyte apoptosis and alters thymic selection.

Campbell KJ, Gray DH, Anstee N, Strasser A, Cory S.

Cell Death Differ. 2012 Dec;19(12):1962-71. doi: 10.1038/cdd.2012.84. Epub 2012 Jun 29.

PMID:
22743995
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

BH3-only activator proteins Bid and Bim are dispensable for Bak/Bax-dependent thrombocyte apoptosis induced by Bcl-xL deficiency: molecular requisites for the mitochondrial pathway to apoptosis in platelets.

Kodama T, Takehara T, Hikita H, Shimizu S, Shigekawa M, Li W, Miyagi T, Hosui A, Tatsumi T, Ishida H, Kanto T, Hiramatsu N, Yin XM, Hayashi N.

J Biol Chem. 2011 Apr 22;286(16):13905-13. doi: 10.1074/jbc.M110.195370. Epub 2011 Mar 2.

PMID:
21367852
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

p14(ARF)-induced apoptosis in p53 protein-deficient cells is mediated by BH3-only protein-independent derepression of Bak protein through down-regulation of Mcl-1 and Bcl-xL proteins.

Müer A, Overkamp T, Gillissen B, Richter A, Pretzsch T, Milojkovic A, Dörken B, Daniel PT, Hemmati P.

J Biol Chem. 2012 May 18;287(21):17343-52. doi: 10.1074/jbc.M111.314898. Epub 2012 Feb 21.

PMID:
22354970
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Dual inhibition of Bcl-2 and Bcl-xL strikingly enhances PI3K inhibition-induced apoptosis in human myeloid leukemia cells through a GSK3- and Bim-dependent mechanism.

Rahmani M, Aust MM, Attkisson E, Williams DC Jr, Ferreira-Gonzalez A, Grant S.

Cancer Res. 2013 Feb 15;73(4):1340-51. doi: 10.1158/0008-5472.CAN-12-1365. Epub 2012 Dec 12.

PMID:
23243017
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Mcl-1 and Bcl-xL regulate Bak/Bax-dependent apoptosis of the megakaryocytic lineage at multistages.

Kodama T, Hikita H, Kawaguchi T, Shigekawa M, Shimizu S, Hayashi Y, Li W, Miyagi T, Hosui A, Tatsumi T, Kanto T, Hiramatsu N, Kiyomizu K, Tadokoro S, Tomiyama Y, Hayashi N, Takehara T.

Cell Death Differ. 2012 Nov;19(11):1856-69. doi: 10.1038/cdd.2012.88. Epub 2012 Jul 13.

PMID:
22790873
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

The novel BH3 α-helix mimetic JY-1-106 induces apoptosis in a subset of cancer cells (lung cancer, colon cancer and mesothelioma) by disrupting Bcl-xL and Mcl-1 protein-protein interactions with Bak.

Cao X, Yap JL, Newell-Rogers MK, Peddaboina C, Jiang W, Papaconstantinou HT, Jupitor D, Rai A, Jung KY, Tubin RP, Yu W, Vanommeslaeghe K, Wilder PT, MacKerell AD Jr, Fletcher S, Smythe RW.

Mol Cancer. 2013 May 16;12(1):42. doi: 10.1186/1476-4598-12-42.

PMID:
23680104
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Apoptotic regulation in primitive hematopoietic precursors.

Peters R, Leyvraz S, Perey L.

Blood. 1998 Sep 15;92(6):2041-52.

PMID:
9731062
[PubMed - indexed for MEDLINE]
Free Article
10.

Endogenous Bak inhibitors Mcl-1 and Bcl-xL: differential impact on TRAIL resistance in Bax-deficient carcinoma.

Gillissen B, Wendt J, Richter A, Richter A, Müer A, Overkamp T, Gebhardt N, Preissner R, Belka C, Dörken B, Daniel PT.

J Cell Biol. 2010 Mar 22;188(6):851-62. doi: 10.1083/jcb.200912070.

PMID:
20308427
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis.

Rathmell JC, Lindsten T, Zong WX, Cinalli RM, Thompson CB.

Nat Immunol. 2002 Oct;3(10):932-9. Epub 2002 Sep 3.

PMID:
12244308
[PubMed - indexed for MEDLINE]
12.

Bcl-w forms complexes with Bax and Bak, and elevated ratios of Bax/Bcl-w and Bak/Bcl-w correspond to spermatogonial and spermatocyte apoptosis in the testis.

Yan W, Samson M, Jégou B, Toppari J.

Mol Endocrinol. 2000 May;14(5):682-99.

PMID:
10809232
[PubMed - indexed for MEDLINE]
13.

Predominant requirement of Bax for apoptosis in HCT116 cells is determined by Mcl-1's inhibitory effect on Bak.

Wang C, Youle RJ.

Oncogene. 2012 Jun 28;31(26):3177-89. doi: 10.1038/onc.2011.497. Epub 2011 Nov 7.

PMID:
22056880
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Bax- and Bak-induced cell death in the fission yeast Schizosaccharomyces pombe.

Jürgensmeier JM, Krajewski S, Armstrong RC, Wilson GM, Oltersdorf T, Fritz LC, Reed JC, Ottilie S.

Mol Biol Cell. 1997 Feb;8(2):325-39.

PMID:
9190211
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis.

Hutcheson J, Scatizzi JC, Bickel E, Brown NJ, Bouillet P, Strasser A, Perlman H.

J Exp Med. 2005 Jun 20;201(12):1949-60.

PMID:
15967824
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Pseudomonas exotoxin A-mediated apoptosis is Bak dependent and preceded by the degradation of Mcl-1.

Du X, Youle RJ, FitzGerald DJ, Pastan I.

Mol Cell Biol. 2010 Jul;30(14):3444-52. doi: 10.1128/MCB.00813-09. Epub 2010 May 10.

PMID:
20457813
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins.

Willis SN, Chen L, Dewson G, Wei A, Naik E, Fletcher JI, Adams JM, Huang DC.

Genes Dev. 2005 Jun 1;19(11):1294-305. Epub 2005 May 18.

PMID:
15901672
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

M. leprae inhibits apoptosis in THP-1 cells by downregulation of Bad and Bak and upregulation of Mcl-1 gene expression.

Hasan Z, Ashraf M, Tayyebi A, Hussain R.

BMC Microbiol. 2006 Sep 18;6:78.

PMID:
16978419
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

BH3-only protein bid participates in the Bcl-2 network in healthy liver cells.

Hikita H, Takehara T, Kodama T, Shimizu S, Hosui A, Miyagi T, Tatsumi T, Ishida H, Ohkawa K, Li W, Kanto T, Hiramatsu N, Hennighausen L, Yin XM, Hayashi N.

Hepatology. 2009 Dec;50(6):1972-80. doi: 10.1002/hep.23207.

PMID:
19839062
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Neurons exclusively express N-Bak, a BH3 domain-only Bak isoform that promotes neuronal apoptosis.

Uo T, Kinoshita Y, Morrison RS.

J Biol Chem. 2005 Mar 11;280(10):9065-73. Epub 2004 Dec 8.

PMID:
15590665
[PubMed - indexed for MEDLINE]
Free Article

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