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Items: 1 to 20 of 98

1.

Neonatal insulin action impairs hypothalamic neurocircuit formation in response to maternal high-fat feeding.

Vogt MC, Paeger L, Hess S, Steculorum SM, Awazawa M, Hampel B, Neupert S, Nicholls HT, Mauer J, Hausen AC, Predel R, Kloppenburg P, Horvath TL, Brüning JC.

Cell. 2014 Jan 30;156(3):495-509. doi: 10.1016/j.cell.2014.01.008. Epub 2014 Jan 23.

2.

Mom's milk molds neural wiring for metabolism.

Cakir I, Ozcan U.

Cell. 2014 Jan 30;156(3):396-7. doi: 10.1016/j.cell.2014.01.033.

3.

Differential responses of orexigenic neuropeptides to fasting in offspring of obese mothers.

Chen H, Morris MJ.

Obesity (Silver Spring). 2009 Jul;17(7):1356-62. doi: 10.1038/oby.2009.56. Epub 2009 Mar 12.

PMID:
19282828
4.

Respective contributions of maternal insulin resistance and diet to metabolic and hypothalamic phenotypes of progeny.

Carmody JS, Wan P, Accili D, Zeltser LM, Leibel RL.

Obesity (Silver Spring). 2011 Mar;19(3):492-9. doi: 10.1038/oby.2010.245. Epub 2010 Oct 14.

5.

AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons.

Claret M, Smith MA, Batterham RL, Selman C, Choudhury AI, Fryer LG, Clements M, Al-Qassab H, Heffron H, Xu AW, Speakman JR, Barsh GS, Viollet B, Vaulont S, Ashford ML, Carling D, Withers DJ.

J Clin Invest. 2007 Aug;117(8):2325-36.

6.

Enhanced Stat3 activation in POMC neurons provokes negative feedback inhibition of leptin and insulin signaling in obesity.

Ernst MB, Wunderlich CM, Hess S, Paehler M, Mesaros A, Koralov SB, Kleinridders A, Husch A, Münzberg H, Hampel B, Alber J, Kloppenburg P, Brüning JC, Wunderlich FT.

J Neurosci. 2009 Sep 16;29(37):11582-93. doi: 10.1523/JNEUROSCI.5712-08.2009.

7.

GABA type B receptor signaling in proopiomelanocortin neurons protects against obesity, insulin resistance, and hypothalamic inflammation in male mice on a high-fat diet.

Ito Y, Banno R, Shibata M, Adachi K, Hagimoto S, Hagiwara D, Ozawa Y, Goto M, Suga H, Sugimura Y, Bettler B, Oiso Y, Arima H.

J Neurosci. 2013 Oct 23;33(43):17166-73. doi: 10.1523/JNEUROSCI.0897-13.2013.

8.

Maternal obesity impairs brain glucose metabolism and neural response to hyperglycemia in male rat offspring.

Chen H, Simar D, Morris MJ.

J Neurochem. 2014 Apr;129(2):297-303. doi: 10.1111/jnc.12623. Epub 2013 Dec 15.

9.

Deletion of Lkb1 in pro-opiomelanocortin neurons impairs peripheral glucose homeostasis in mice.

Claret M, Smith MA, Knauf C, Al-Qassab H, Woods A, Heslegrave A, Piipari K, Emmanuel JJ, Colom A, Valet P, Cani PD, Begum G, White A, Mucket P, Peters M, Mizuno K, Batterham RL, Giese KP, Ashworth A, Burcelin R, Ashford ML, Carling D, Withers DJ.

Diabetes. 2011 Mar;60(3):735-45. doi: 10.2337/db10-1055. Epub 2011 Jan 24.

10.

The role of insulin receptor substrate 2 in hypothalamic and beta cell function.

Choudhury AI, Heffron H, Smith MA, Al-Qassab H, Xu AW, Selman C, Simmgen M, Clements M, Claret M, Maccoll G, Bedford DC, Hisadome K, Diakonov I, Moosajee V, Bell JD, Speakman JR, Batterham RL, Barsh GS, Ashford ML, Withers DJ.

J Clin Invest. 2005 Apr;115(4):940-50. Epub 2005 Mar 24.

11.

Cellular insulin resistance disrupts hypothalamic mHypoA-POMC/GFP neuronal signaling pathways.

Nazarians-Armavil A, Chalmers JA, Lee CB, Ye W, Belsham DD.

J Endocrinol. 2013 Nov 28;220(1):13-24. doi: 10.1530/JOE-13-0334. Print 2014 Jan.

12.

Maternal and postweaning diet interaction alters hypothalamic gene expression and modulates response to a high-fat diet in male offspring.

Page KC, Malik RE, Ripple JA, Anday EK.

Am J Physiol Regul Integr Comp Physiol. 2009 Oct;297(4):R1049-57. doi: 10.1152/ajpregu.90585.2008. Epub 2009 Aug 5.

13.

Synaptic input organization of the melanocortin system predicts diet-induced hypothalamic reactive gliosis and obesity.

Horvath TL, Sarman B, García-Cáceres C, Enriori PJ, Sotonyi P, Shanabrough M, Borok E, Argente J, Chowen JA, Perez-Tilve D, Pfluger PT, Brönneke HS, Levin BE, Diano S, Cowley MA, Tschöp MH.

Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14875-80. doi: 10.1073/pnas.1004282107. Epub 2010 Aug 2.

14.

Maternal prenatal undernutrition alters the response of POMC neurons to energy status variation in adult male rat offspring.

Breton C, Lukaszewski MA, Risold PY, Enache M, Guillemot J, Rivière G, Delahaye F, Lesage J, Dutriez-Casteloot I, Laborie C, Vieau D.

Am J Physiol Endocrinol Metab. 2009 Mar;296(3):E462-72. doi: 10.1152/ajpendo.90740.2008. Epub 2008 Dec 16.

15.

Hypothalamic endoplasmic reticulum stress and insulin resistance in offspring of mice dams fed high-fat diet during pregnancy and lactation.

Melo AM, Benatti RO, Ignacio-Souza LM, Okino C, Torsoni AS, Milanski M, Velloso LA, Torsoni MA.

Metabolism. 2014 May;63(5):682-92. doi: 10.1016/j.metabol.2014.02.002. Epub 2014 Feb 10.

PMID:
24636055
16.

Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production.

Könner AC, Janoschek R, Plum L, Jordan SD, Rother E, Ma X, Xu C, Enriori P, Hampel B, Barsh GS, Kahn CR, Cowley MA, Ashcroft FM, Brüning JC.

Cell Metab. 2007 Jun;5(6):438-49.

18.

Dominant role of the p110beta isoform of PI3K over p110alpha in energy homeostasis regulation by POMC and AgRP neurons.

Al-Qassab H, Smith MA, Irvine EE, Guillermet-Guibert J, Claret M, Choudhury AI, Selman C, Piipari K, Clements M, Lingard S, Chandarana K, Bell JD, Barsh GS, Smith AJ, Batterham RL, Ashford ML, Vanhaesebroeck B, Withers DJ.

Cell Metab. 2009 Nov;10(5):343-54. doi: 10.1016/j.cmet.2009.09.008.

19.

Phosphatidyl inositol 3-kinase signaling in hypothalamic proopiomelanocortin neurons contributes to the regulation of glucose homeostasis.

Hill JW, Xu Y, Preitner F, Fukuda M, Cho YR, Luo J, Balthasar N, Coppari R, Cantley LC, Kahn BB, Zhao JJ, Elmquist JK.

Endocrinology. 2009 Nov;150(11):4874-82. doi: 10.1210/en.2009-0454. Epub 2009 Oct 9.

20.
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