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Results: 1 to 20 of 102

1.

Bioenergetic modulation overcomes glucocorticoid resistance in T-lineage acute lymphoblastic leukaemia.

Samuels AL, Heng JY, Beesley AH, Kees UR.

Br J Haematol. 2014 Apr;165(1):57-66. doi: 10.1111/bjh.12727. Epub 2014 Jan 23.

PMID:
24456076
[PubMed - indexed for MEDLINE]
2.

Glucocorticoid resistance in T-lineage acute lymphoblastic leukaemia is associated with a proliferative metabolism.

Beesley AH, Firth MJ, Ford J, Weller RE, Freitas JR, Perera KU, Kees UR.

Br J Cancer. 2009 Jun 16;100(12):1926-36. doi: 10.1038/sj.bjc.6605072. Epub 2009 May 12. Erratum in: Br J Cancer. 2010 Mar 30;102(7):1200.

PMID:
19436302
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Inhibition of glycolysis modulates prednisolone resistance in acute lymphoblastic leukemia cells.

Hulleman E, Kazemier KM, Holleman A, VanderWeele DJ, Rudin CM, Broekhuis MJ, Evans WE, Pieters R, Den Boer ML.

Blood. 2009 Feb 26;113(9):2014-21. doi: 10.1182/blood-2008-05-157842. Epub 2008 Oct 31.

PMID:
18978206
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Rapamycin sensitizes T-ALL cells to dexamethasone-induced apoptosis.

Gu L, Zhou C, Liu H, Gao J, Li Q, Mu D, Ma Z.

J Exp Clin Cancer Res. 2010 Nov 18;29:150. doi: 10.1186/1756-9966-29-150.

PMID:
21083937
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Low-dose arsenic trioxide sensitizes glucocorticoid-resistant acute lymphoblastic leukemia cells to dexamethasone via an Akt-dependent pathway.

Bornhauser BC, Bonapace L, Lindholm D, Martinez R, Cario G, Schrappe M, Niggli FK, Schäfer BW, Bourquin JP.

Blood. 2007 Sep 15;110(6):2084-91. Epub 2007 May 30.

PMID:
17537996
[PubMed - indexed for MEDLINE]
Free Article
6.

Pro-apoptotic protein BIM in apoptosis of glucocorticoid-sensitive and -resistant acute lymphoblastic leukemia CEM cells.

Zhao YN, Guo X, Ma ZG, Gu L, Ge J, Li Q.

Med Oncol. 2011 Dec;28(4):1609-17. doi: 10.1007/s12032-010-9641-x. Epub 2010 Aug 10.

PMID:
20697841
[PubMed - indexed for MEDLINE]
7.

Preclinical analysis of the γ-secretase inhibitor PF-03084014 in combination with glucocorticoids in T-cell acute lymphoblastic leukemia.

Samon JB, Castillo-Martin M, Hadler M, Ambesi-Impiobato A, Paietta E, Racevskis J, Wiernik PH, Rowe JM, Jakubczak J, Randolph S, Cordon-Cardo C, Ferrando AA.

Mol Cancer Ther. 2012 Jul;11(7):1565-75. doi: 10.1158/1535-7163.MCT-11-0938. Epub 2012 Apr 13.

PMID:
22504949
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Receptor mutation is not a common mechanism of naturally occurring glucocorticoid resistance in leukaemia cell lines.

Beesley AH, Weller RE, Senanayake S, Welch M, Kees UR.

Leuk Res. 2009 Feb;33(2):321-5. doi: 10.1016/j.leukres.2008.08.007. Epub 2008 Sep 11.

PMID:
18789525
[PubMed - indexed for MEDLINE]
9.

Glucocorticoid resistance in paediatric acute lymphoblastic leukaemia.

Bhadri VA, Trahair TN, Lock RB.

J Paediatr Child Health. 2012 Aug;48(8):634-40. doi: 10.1111/j.1440-1754.2011.02212.x. Epub 2011 Nov 3. Review.

PMID:
22050419
[PubMed - indexed for MEDLINE]
10.

Energy metabolism of leukemia cells: glycolysis versus oxidative phosphorylation.

Suganuma K, Miwa H, Imai N, Shikami M, Gotou M, Goto M, Mizuno S, Takahashi M, Yamamoto H, Hiramatsu A, Wakabayashi M, Watarai M, Hanamura I, Imamura A, Mihara H, Nitta M.

Leuk Lymphoma. 2010 Nov;51(11):2112-9. doi: 10.3109/10428194.2010.512966. Epub 2010 Sep 22.

PMID:
20860495
[PubMed - indexed for MEDLINE]
11.

Histone deacetylase inhibitors synergistically potentiate death receptor 4-mediated apoptotic cell death of human T-cell acute lymphoblastic leukemia cells.

Sung ES, Kim A, Park JS, Chung J, Kwon MH, Kim YS.

Apoptosis. 2010 Oct;15(10):1256-69. doi: 10.1007/s10495-010-0521-9.

PMID:
20582477
[PubMed - indexed for MEDLINE]
12.

KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia.

Etchin J, Sanda T, Mansour MR, Kentsis A, Montero J, Le BT, Christie AL, McCauley D, Rodig SJ, Kauffman M, Shacham S, Stone R, Letai A, Kung AL, Thomas Look A.

Br J Haematol. 2013 Apr;161(1):117-27. doi: 10.1111/bjh.12231. Epub 2013 Feb 4.

PMID:
23373539
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Anisomycin induces apoptosis of glucocorticoid resistant acute lymphoblastic leukemia CEM-C1 cells via activation of mitogen-activated protein kinases p38 and JNK.

Liu Y, Ge J, Li Q, Gu L, Guo X, Ma ZG, Zhu YP.

Neoplasma. 2013;60(1):101-10. doi: 10.4149/neo_2013_014.

PMID:
23067223
[PubMed - indexed for MEDLINE]
14.

Mitochondria-targeted drugs synergize with 2-deoxyglucose to trigger breast cancer cell death.

Cheng G, Zielonka J, Dranka BP, McAllister D, Mackinnon AC Jr, Joseph J, Kalyanaraman B.

Cancer Res. 2012 May 15;72(10):2634-44. doi: 10.1158/0008-5472.CAN-11-3928. Epub 2012 Mar 19.

PMID:
22431711
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Oligomycin-induced bioenergetic adaptation in cancer cells with heterogeneous bioenergetic organization.

Hao W, Chang CP, Tsao CC, Xu J.

J Biol Chem. 2010 Apr 23;285(17):12647-54. doi: 10.1074/jbc.M109.084194. Epub 2010 Jan 28.

PMID:
20110356
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

A facile, branched DNA assay to quantitatively measure glucocorticoid receptor auto-regulation in T-cell acute lymphoblastic leukemia.

Schwartz JR, Sarvaiya PJ, Leiva LE, Velez MC, Singleton TC, Yu LC, Vedeckis WV.

Chin J Cancer. 2012 Aug;31(8):381-91. doi: 10.5732/cjc.012.10044. Epub 2012 Jun 26.

PMID:
22739263
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Resistance to glucocorticoid-induced apoptosis in human T-cell acute lymphoblastic leukemia CEM-C1 cells is due to insufficient glucocorticoid receptor expression.

Geley S, Hartmann BL, Hala M, Strasser-Wozak EM, Kapelari K, Kofler R.

Cancer Res. 1996 Nov 1;56(21):5033-8.

PMID:
8895760
[PubMed - indexed for MEDLINE]
Free Article
18.

GX15-070 (obatoclax) overcomes glucocorticoid resistance in acute lymphoblastic leukemia through induction of apoptosis and autophagy.

Heidari N, Hicks MA, Harada H.

Cell Death Dis. 2010 Sep 16;1:e76. doi: 10.1038/cddis.2010.53.

PMID:
21364679
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

FBXW7 regulates glucocorticoid response in T-cell acute lymphoblastic leukaemia by targeting the glucocorticoid receptor for degradation.

Malyukova A, Brown S, Papa R, O'Brien R, Giles J, Trahair TN, Dalla Pozza L, Sutton R, Liu T, Haber M, Norris MD, Lock RB, Sangfelt O, Marshall GM.

Leukemia. 2013 Apr;27(5):1053-62. doi: 10.1038/leu.2012.361. Epub 2012 Dec 11.

PMID:
23228967
[PubMed - indexed for MEDLINE]
20.

Influence of wild-type MLL on glucocorticoid sensitivity and response to DNA-damage in pediatric acute lymphoblastic leukemia.

Beesley AH, Rampellini JL, Palmer ML, Heng JY, Samuels AL, Firth MJ, Ford J, Kees UR.

Mol Cancer. 2010 Oct 28;9:284. doi: 10.1186/1476-4598-9-284.

PMID:
20979663
[PubMed - indexed for MEDLINE]
Free PMC Article

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