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Items: 1 to 20 of 92

1.

Regulation of human MutYH DNA glycosylase by the E3 ubiquitin ligase mule.

Dorn J, Ferrari E, Imhof R, Ziegler N, Hübscher U.

J Biol Chem. 2014 Mar 7;289(10):7049-58. doi: 10.1074/jbc.M113.536094. Epub 2014 Jan 17.

2.

MUTYH DNA glycosylase: the rationale for removing undamaged bases from the DNA.

Markkanen E, Dorn J, Hübscher U.

Front Genet. 2013 Feb 28;4:18. doi: 10.3389/fgene.2013.00018. eCollection 2013.

3.

Regulation of oxidative DNA damage repair: the adenine:8-oxo-guanine problem.

Markkanen E, Hübscher U, van Loon B.

Cell Cycle. 2012 Mar 15;11(6):1070-5. doi: 10.4161/cc.11.6.19448. Epub 2012 Mar 15.

PMID:
22370481
4.

An 8-oxo-guanine repair pathway coordinated by MUTYH glycosylase and DNA polymerase lambda.

van Loon B, Hübscher U.

Proc Natl Acad Sci U S A. 2009 Oct 27;106(43):18201-6. doi: 10.1073/pnas.0907280106. Epub 2009 Oct 9.

5.

Involvement of Werner syndrome protein in MUTYH-mediated repair of oxidative DNA damage.

Kanagaraj R, Parasuraman P, Mihaljevic B, van Loon B, Burdova K, König C, Furrer A, Bohr VA, Hübscher U, Janscak P.

Nucleic Acids Res. 2012 Sep 1;40(17):8449-59. Epub 2012 Jun 29.

6.

Understanding the role of the Q338H MUTYH variant in oxidative damage repair.

Turco E, Ventura I, Minoprio A, Russo MT, Torreri P, Degan P, Molatore S, Ranzani GN, Bignami M, Mazzei F.

Nucleic Acids Res. 2013 Apr;41(7):4093-103. doi: 10.1093/nar/gkt130. Epub 2013 Mar 4.

7.
8.

Role of MUTYH and MSH2 in the control of oxidative DNA damage, genetic instability, and tumorigenesis.

Russo MT, De Luca G, Casorelli I, Degan P, Molatore S, Barone F, Mazzei F, Pannellini T, Musiani P, Bignami M.

Cancer Res. 2009 May 15;69(10):4372-9. doi: 10.1158/0008-5472.CAN-08-3292. Epub 2009 May 12.

9.

Adenine removal activity and bacterial complementation with the human MutY homologue (MUTYH) and Y165C, G382D, P391L and Q324R variants associated with colorectal cancer.

Kundu S, Brinkmeyer MK, Livingston AL, David SS.

DNA Repair (Amst). 2009 Dec 3;8(12):1400-10. doi: 10.1016/j.dnarep.2009.09.009.

10.

Role of MUTYH in human cancer.

Mazzei F, Viel A, Bignami M.

Mutat Res. 2013 Mar-Apr;743-744:33-43. doi: 10.1016/j.mrfmmm.2013.03.003. Epub 2013 Mar 16. Review.

PMID:
23507534
11.

A functional analysis of the DNA glycosylase activity of mouse MUTYH protein excising 2-hydroxyadenine opposite guanine in DNA.

Ushijima Y, Tominaga Y, Miura T, Tsuchimoto D, Sakumi K, Nakabeppu Y.

Nucleic Acids Res. 2005 Jan 28;33(2):672-82. Print 2005.

12.

Ser 524 is a phosphorylation site in MUTYH and Ser 524 mutations alter 8-oxoguanine (OG): a mismatch recognition.

Kundu S, Brinkmeyer MK, Eigenheer RA, David SS.

DNA Repair (Amst). 2010 Oct 5;9(10):1026-37. doi: 10.1016/j.dnarep.2010.07.002. Epub 2010 Aug 17.

13.

USP7S-dependent inactivation of Mule regulates DNA damage signalling and repair.

Khoronenkova SV, Dianov GL.

Nucleic Acids Res. 2013 Feb 1;41(3):1750-6. doi: 10.1093/nar/gks1359. Epub 2012 Dec 28.

14.

Alterations of the base excision repair gene MUTYH in sporadic colorectal cancer.

Kuno T, Matsubara N, Tsuda S, Kobayashi M, Hamanaka M, Yamagishi D, Tsukamoto K, Yamano T, Noda M, Ikeuchi H, Kim S, Tamura K, Tomita N.

Oncol Rep. 2012 Aug;28(2):473-80. doi: 10.3892/or.2012.1836. Epub 2012 May 25.

PMID:
22641385
15.

Cancer-associated variants and a common polymorphism of MUTYH exhibit reduced repair of oxidative DNA damage using a GFP-based assay in mammalian cells.

Raetz AG, Xie Y, Kundu S, Brinkmeyer MK, Chang C, David SS.

Carcinogenesis. 2012 Nov;33(11):2301-9. doi: 10.1093/carcin/bgs270. Epub 2012 Aug 26.

16.

Coordination of MYH DNA glycosylase and APE1 endonuclease activities via physical interactions.

Luncsford PJ, Manvilla BA, Patterson DN, Malik SS, Jin J, Hwang BJ, Gunther R, Kalvakolanu S, Lipinski LJ, Yuan W, Lu W, Drohat AC, Lu AL, Toth EA.

DNA Repair (Amst). 2013 Dec;12(12):1043-52. doi: 10.1016/j.dnarep.2013.09.007. Epub 2013 Oct 24.

17.

Distinct functional consequences of MUTYH variants associated with colorectal cancer: Damaged DNA affinity, glycosylase activity and interaction with PCNA and Hus1.

Brinkmeyer MK, David SS.

DNA Repair (Amst). 2015 Oct;34:39-51. doi: 10.1016/j.dnarep.2015.08.001. Epub 2015 Aug 12.

PMID:
26377631
18.

MutY-glycosylase: an overview on mutagenesis and activities beyond the GO system.

de Oliveira AH, da Silva AE, de Oliveira IM, Henriques JA, Agnez-Lima LF.

Mutat Res. 2014 Nov;769:119-31. doi: 10.1016/j.mrfmmm.2014.08.002. Epub 2014 Aug 13. Review.

PMID:
25771731
19.

Oxygen as a friend and enemy: How to combat the mutational potential of 8-oxo-guanine.

van Loon B, Markkanen E, Hübscher U.

DNA Repair (Amst). 2010 Jun 4;9(6):604-16. doi: 10.1016/j.dnarep.2010.03.004. Review.

PMID:
20399712
20.

Ubiquitin ligase ARF-BP1/Mule modulates base excision repair.

Parsons JL, Tait PS, Finch D, Dianova II, Edelmann MJ, Khoronenkova SV, Kessler BM, Sharma RA, McKenna WG, Dianov GL.

EMBO J. 2009 Oct 21;28(20):3207-15. doi: 10.1038/emboj.2009.243. Epub 2009 Aug 27.

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