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Sepp1(UF) forms are N-terminal selenoprotein P truncations that have peroxidase activity when coupled with thioredoxin reductase-1.

Kurokawa S, Eriksson S, Rose KL, Wu S, Motley AK, Hill S, Winfrey VP, McDonald WH, Capecchi MR, Atkins JF, Arnér ES, Hill KE, Burk RF.

Free Radic Biol Med. 2014 Apr;69:67-76. doi: 10.1016/j.freeradbiomed.2014.01.010. Epub 2014 Jan 14.


Long isoform mouse selenoprotein P (Sepp1) supplies rat myoblast L8 cells with selenium via endocytosis mediated by heparin binding properties and apolipoprotein E receptor-2 (ApoER2).

Kurokawa S, Hill KE, McDonald WH, Burk RF.

J Biol Chem. 2012 Aug 17;287(34):28717-26. doi: 10.1074/jbc.M112.383521. Epub 2012 Jul 2.


Regulation of Selenium Metabolism and Transport.

Burk RF, Hill KE.

Annu Rev Nutr. 2015;35:109-34. doi: 10.1146/annurev-nutr-071714-034250. Epub 2015 May 13. Review.


Isoform-specific binding of selenoprotein P to the β-propeller domain of apolipoprotein E receptor 2 mediates selenium supply.

Kurokawa S, Bellinger FP, Hill KE, Burk RF, Berry MJ.

J Biol Chem. 2014 Mar 28;289(13):9195-207. doi: 10.1074/jbc.M114.549014. Epub 2014 Feb 13.


Selenoprotein P-expression, functions, and roles in mammals.

Burk RF, Hill KE.

Biochim Biophys Acta. 2009 Nov;1790(11):1441-7. doi: 10.1016/j.bbagen.2009.03.026. Epub 2009 Apr 1. Review.


Megalin mediates selenoprotein P uptake by kidney proximal tubule epithelial cells.

Olson GE, Winfrey VP, Hill KE, Burk RF.

J Biol Chem. 2008 Mar 14;283(11):6854-60. doi: 10.1074/jbc.M709945200. Epub 2008 Jan 3.


Interference of selenium and selenoproteins with the insulin-regulated carbohydrate and lipid metabolism.

Steinbrenner H.

Free Radic Biol Med. 2013 Dec;65:1538-47. doi: 10.1016/j.freeradbiomed.2013.07.016. Epub 2013 Jul 18. Review.


Production of selenoprotein P (Sepp1) by hepatocytes is central to selenium homeostasis.

Hill KE, Wu S, Motley AK, Stevenson TD, Winfrey VP, Capecchi MR, Atkins JF, Burk RF.

J Biol Chem. 2012 Nov 23;287(48):40414-24. doi: 10.1074/jbc.M112.421404. Epub 2012 Oct 4.


Mice lacking selenoprotein P and selenocysteine lyase exhibit severe neurological dysfunction, neurodegeneration, and audiogenic seizures.

Byrns CN, Pitts MW, Gilman CA, Hashimoto AC, Berry MJ.

J Biol Chem. 2014 Apr 4;289(14):9662-74. doi: 10.1074/jbc.M113.540682. Epub 2014 Feb 11.


The selenium-rich C-terminal domain of mouse selenoprotein P is necessary for the supply of selenium to brain and testis but not for the maintenance of whole body selenium.

Hill KE, Zhou J, Austin LM, Motley AK, Ham AJ, Olson GE, Atkins JF, Gesteland RF, Burk RF.

J Biol Chem. 2007 Apr 13;282(15):10972-80. Epub 2007 Feb 20.


Crystal structure and catalysis of the selenoprotein thioredoxin reductase 1.

Cheng Q, Sandalova T, Lindqvist Y, Arnér ES.

J Biol Chem. 2009 Feb 6;284(6):3998-4008. doi: 10.1074/jbc.M807068200. Epub 2008 Dec 3.


Why is mammalian thioredoxin reductase 1 so dependent upon the use of selenium?

Lothrop AP, Snider GW, Ruggles EL, Hondal RJ.

Biochemistry. 2014 Jan 28;53(3):554-65. doi: 10.1021/bi400651x. Epub 2014 Jan 15.


Maternal-fetal transfer of selenium in the mouse.

Burk RF, Olson GE, Hill KE, Winfrey VP, Motley AK, Kurokawa S.

FASEB J. 2013 Aug;27(8):3249-56. doi: 10.1096/fj.13-231852. Epub 2013 May 7.


Selenium homeostasis and antioxidant selenoproteins in brain: implications for disorders in the central nervous system.

Steinbrenner H, Sies H.

Arch Biochem Biophys. 2013 Aug 15;536(2):152-7. doi: 10.1016/ Epub 2013 Mar 13. Review.


Overexpression of enzymatically active human cytosolic and mitochondrial thioredoxin reductase in HEK-293 cells. Effect on cell growth and differentiation.

Nalvarte I, Damdimopoulos AE, Nystöm C, Nordman T, Miranda-Vizuete A, Olsson JM, Eriksson L, Björnstedt M, Arnér ES, Spyrou G.

J Biol Chem. 2004 Dec 24;279(52):54510-7. Epub 2004 Oct 7.


Selenium, selenoproteins and human health: a review.

Brown KM, Arthur JR.

Public Health Nutr. 2001 Apr;4(2B):593-9. Review.


Penultimate selenocysteine residue replaced by cysteine in thioredoxin reductase from selenium-deficient rat liver.

Lu J, Zhong L, Lönn ME, Burk RF, Hill KE, Holmgren A.

FASEB J. 2009 Aug;23(8):2394-402. doi: 10.1096/fj.08-127662. Epub 2009 Apr 7.

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