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Items: 1 to 20 of 228


Paradoxic effects of metformin on endothelial cells and angiogenesis.

Dallaglio K, Bruno A, Cantelmo AR, Esposito AI, Ruggiero L, Orecchioni S, Calleri A, Bertolini F, Pfeffer U, Noonan DM, Albini A.

Carcinogenesis. 2014 May;35(5):1055-66. doi: 10.1093/carcin/bgu001. Epub 2014 Jan 13.


SKLB610: a novel potential inhibitor of vascular endothelial growth factor receptor tyrosine kinases inhibits angiogenesis and tumor growth in vivo.

Cao ZX, Zheng RL, Lin HJ, Luo SD, Zhou Y, Xu YZ, Zeng XX, Wang Z, Zhou LN, Mao YQ, Yang L, Wei YQ, Yu LT, Yang SY, Zhao YL.

Cell Physiol Biochem. 2011;27(5):565-74. doi: 10.1159/000329978. Epub 2011 Jun 15.


Fisetin inhibits various attributes of angiogenesis in vitro and in vivo--implications for angioprevention.

Bhat TA, Nambiar D, Pal A, Agarwal R, Singh RP.

Carcinogenesis. 2012 Feb;33(2):385-93. doi: 10.1093/carcin/bgr282. Epub 2011 Dec 1.


Blocking angiogenesis and tumorigenesis with GFA-116, a synthetic molecule that inhibits binding of vascular endothelial growth factor to its receptor.

Sun J, Blaskovich MA, Jain RK, Delarue F, Paris D, Brem S, Wotoczek-Obadia M, Lin Q, Coppola D, Choi K, Mullan M, Hamilton AD, Sebti SM.

Cancer Res. 2004 May 15;64(10):3586-92.


The vitamin K-dependent anticoagulant factor, protein S, inhibits multiple VEGF-A-induced angiogenesis events in a Mer- and SHP2-dependent manner.

Fraineau S, Monvoisin A, Clarhaut J, Talbot J, Simonneau C, Kanthou C, Kanse SM, Philippe M, Benzakour O.

Blood. 2012 Dec 13;120(25):5073-83. doi: 10.1182/blood-2012-05-429183. Epub 2012 Oct 12.


Growth-regulated oncogene is pivotal in thrombin-induced angiogenesis.

Caunt M, Hu L, Tang T, Brooks PC, Ibrahim S, Karpatkin S.

Cancer Res. 2006 Apr 15;66(8):4125-32.


Antiangiogenic mechanisms of PJ-8, a novel inhibitor of vascular endothelial growth factor receptor signaling.

Huang SW, Lien JC, Kuo SC, Huang TF.

Carcinogenesis. 2012 May;33(5):1022-30. doi: 10.1093/carcin/bgs127. Epub 2012 Mar 20.


Epoxyeicosatrienoic acids are part of the VEGF-activated signaling cascade leading to angiogenesis.

Webler AC, Michaelis UR, Popp R, Barbosa-Sicard E, Murugan A, Falck JR, Fisslthaler B, Fleming I.

Am J Physiol Cell Physiol. 2008 Nov;295(5):C1292-301. doi: 10.1152/ajpcell.00230.2008. Epub 2008 Sep 11.


Morelloflavone, a biflavonoid, inhibits tumor angiogenesis by targeting rho GTPases and extracellular signal-regulated kinase signaling pathways.

Pang X, Yi T, Yi Z, Cho SG, Qu W, Pinkaew D, Fujise K, Liu M.

Cancer Res. 2009 Jan 15;69(2):518-25. doi: 10.1158/0008-5472.CAN-08-2531.


Metformin protects endothelial function in diet-induced obese mice by inhibition of endoplasmic reticulum stress through 5' adenosine monophosphate-activated protein kinase-peroxisome proliferator-activated receptor δ pathway.

Cheang WS, Tian XY, Wong WT, Lau CW, Lee SS, Chen ZY, Yao X, Wang N, Huang Y.

Arterioscler Thromb Vasc Biol. 2014 Apr;34(4):830-6. doi: 10.1161/ATVBAHA.113.301938. Epub 2014 Jan 30.


AMP kinase activation improves angiogenesis in pulmonary artery endothelial cells with in utero pulmonary hypertension.

Teng RJ, Du J, Afolayan AJ, Eis A, Shi Y, Konduri GG.

Am J Physiol Lung Cell Mol Physiol. 2013 Jan 1;304(1):L29-42. doi: 10.1152/ajplung.00200.2012. Epub 2012 Oct 26.


Transforming growth factor-β-activated kinase 1 regulates angiogenesis via AMP-activated protein kinase-α1 and redox balance in endothelial cells.

Zippel N, Malik RA, Frömel T, Popp R, Bess E, Strilic B, Wettschureck N, Fleming I, Fisslthaler B.

Arterioscler Thromb Vasc Biol. 2013 Dec;33(12):2792-9. doi: 10.1161/ATVBAHA.113.301848. Epub 2013 Sep 26.


Activation of fractalkine/CX3CR1 by vascular endothelial cells induces angiogenesis through VEGF-A/KDR and reverses hindlimb ischaemia.

Ryu J, Lee CW, Hong KH, Shin JA, Lim SH, Park CS, Shim J, Nam KB, Choi KJ, Kim YH, Han KH.

Cardiovasc Res. 2008 May 1;78(2):333-40. Epub 2007 Nov 11.


Inhibition of Rho-dependent kinases ROCK I/II activates VEGF-driven retinal neovascularization and sprouting angiogenesis.

Kroll J, Epting D, Kern K, Dietz CT, Feng Y, Hammes HP, Wieland T, Augustin HG.

Am J Physiol Heart Circ Physiol. 2009 Mar;296(3):H893-9. doi: 10.1152/ajpheart.01038.2008. Epub 2009 Jan 30.


CEP-7055: a novel, orally active pan inhibitor of vascular endothelial growth factor receptor tyrosine kinases with potent antiangiogenic activity and antitumor efficacy in preclinical models.

Ruggeri B, Singh J, Gingrich D, Angeles T, Albom M, Yang S, Chang H, Robinson C, Hunter K, Dobrzanski P, Jones-Bolin S, Pritchard S, Aimone L, Klein-Szanto A, Herbert JM, Bono F, Schaeffer P, Casellas P, Bourie B, Pili R, Isaacs J, Ator M, Hudkins R, Vaught J, Mallamo J, Dionne C.

Cancer Res. 2003 Sep 15;63(18):5978-91. Erratum in: Cancer Res. 2003 Nov 1;63(21):7543.


Essential role for endocytosis in the growth factor-stimulated activation of ERK1/2 in endothelial cells.

Gourlaouen M, Welti JC, Vasudev NS, Reynolds AR.

J Biol Chem. 2013 Mar 15;288(11):7467-80. doi: 10.1074/jbc.M112.446401. Epub 2013 Jan 22.


Activation of AMP-activated protein kinase by vascular endothelial growth factor mediates endothelial angiogenesis independently of nitric-oxide synthase.

Stahmann N, Woods A, Spengler K, Heslegrave A, Bauer R, Krause S, Viollet B, Carling D, Heller R.

J Biol Chem. 2010 Apr 2;285(14):10638-52. doi: 10.1074/jbc.M110.108688. Epub 2010 Feb 3.


Increased expression of CYP4Z1 promotes tumor angiogenesis and growth in human breast cancer.

Yu W, Chai H, Li Y, Zhao H, Xie X, Zheng H, Wang C, Wang X, Yang G, Cai X, Falck JR, Yang J.

Toxicol Appl Pharmacol. 2012 Oct 1;264(1):73-83. doi: 10.1016/j.taap.2012.07.019. Epub 2012 Jul 25.

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