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GW1929 inhibits α7 nAChR expression through PPARγ-independent activation of p38 MAPK and inactivation of PI3-K/mTOR: The role of Egr-1.

Hahn SS, Tang Q, Zheng F, Zhao S, Wu J.

Cell Signal. 2014 Apr;26(4):730-9. doi: 10.1016/j.cellsig.2013.12.019. Epub 2014 Jan 8.


Nicotine stimulates PPARbeta/delta expression in human lung carcinoma cells through activation of PI3K/mTOR and suppression of AP-2alpha.

Sun X, Ritzenthaler JD, Zhong X, Zheng Y, Roman J, Han S.

Cancer Res. 2009 Aug 15;69(16):6445-53. doi: 10.1158/0008-5472.CAN-09-1001. Epub 2009 Aug 4.


PPARgamma agonists inhibit angiogenesis by suppressing PKCalpha- and CREB-mediated COX-2 expression in the human endothelium.

Scoditti E, Massaro M, Carluccio MA, Distante A, Storelli C, De Caterina R.

Cardiovasc Res. 2010 May 1;86(2):302-10. doi: 10.1093/cvr/cvp400. Epub 2009 Dec 23.


Nicotine activates cell-signaling pathways through muscle-type and neuronal nicotinic acetylcholine receptors in non-small cell lung cancer cells.

Carlisle DL, Liu X, Hopkins TM, Swick MC, Dhir R, Siegfried JM.

Pulm Pharmacol Ther. 2007;20(6):629-41. Epub 2006 Aug 18.


Induction of apoptosis and nonsteroidal anti-inflammatory drug-activated gene 1 in pancreatic cancer cells by a glycyrrhetinic acid derivative.

Jutooru I, Chadalapaka G, Chintharlapalli S, Papineni S, Safe S.

Mol Carcinog. 2009 Aug;48(8):692-702. doi: 10.1002/mc.20518.


Nicotine stimulates human lung cancer cell growth by inducing fibronectin expression.

Zheng Y, Ritzenthaler JD, Roman J, Han S.

Am J Respir Cell Mol Biol. 2007 Dec;37(6):681-90. Epub 2007 Jun 28.


G Protein-coupled Receptor 40 (GPR40) and Peroxisome Proliferator-activated Receptor γ (PPARγ): AN INTEGRATED TWO-RECEPTOR SIGNALING PATHWAY.

Wang S, Awad KS, Elinoff JM, Dougherty EJ, Ferreyra GA, Wang JY, Cai R, Sun J, Ptasinska A, Danner RL.

J Biol Chem. 2015 Aug 7;290(32):19544-57. doi: 10.1074/jbc.M115.638924. Epub 2015 Jun 23.


Activation of peroxisome proliferator-activated receptor gamma inhibits interleukin-1beta-induced membrane-associated prostaglandin E2 synthase-1 expression in human synovial fibroblasts by interfering with Egr-1.

Cheng S, Afif H, Martel-Pelletier J, Pelletier JP, Li X, Farrajota K, Lavigne M, Fahmi H.

J Biol Chem. 2004 May 21;279(21):22057-65. Epub 2004 Mar 15.


Novel link between prostaglandin E2 (PGE2) and cholinergic signaling in lung cancer: The role of c-Jun in PGE2-induced α7 nicotinic acetylcholine receptor expression and tumor cell proliferation.

Zhong X, Fan Y, Ritzenthaler JD, Zhang W, Wang K, Zhou Q, Roman J.

Thorac Cancer. 2015 Jul;6(4):488-500. doi: 10.1111/1759-7714.12219. Epub 2015 Jan 14.


Carbon monoxide induced PPARγ SUMOylation and UCP2 block inflammatory gene expression in macrophages.

Haschemi A, Chin BY, Jeitler M, Esterbauer H, Wagner O, Bilban M, Otterbein LE.

PLoS One. 2011;6(10):e26376. doi: 10.1371/journal.pone.0026376. Epub 2011 Oct 25.


Role of alpha7-nicotinic acetylcholine receptor in human non-small cell lung cancer proliferation.

Paleari L, Catassi A, Ciarlo M, Cavalieri Z, Bruzzo C, Servent D, Cesario A, Chessa L, Cilli M, Piccardi F, Granone P, Russo P.

Cell Prolif. 2008 Dec;41(6):936-59. doi: 10.1111/j.1365-2184.2008.00566.x. Erratum in: Cell Prolif. 2009 Feb;42(1):122. Cell Prolif. 2009 Aug;42(4):568.


MG624, an α7-nAChR antagonist, inhibits angiogenesis via the Egr-1/FGF2 pathway.

Brown KC, Lau JK, Dom AM, Witte TR, Luo H, Crabtree CM, Shah YH, Shiflett BS, Marcelo AJ, Proper NA, Hardman WE, Egleton RD, Chen YC, Mangiarua EI, Dasgupta P.

Angiogenesis. 2012 Mar;15(1):99-114. doi: 10.1007/s10456-011-9246-9. Epub 2011 Dec 25. Erratum in: Angiogenesis. 2012 Jun;15(2):331. Dosage error in article text.


Mycobacterium tuberculosis activates human macrophage peroxisome proliferator-activated receptor gamma linking mannose receptor recognition to regulation of immune responses.

Rajaram MV, Brooks MN, Morris JD, Torrelles JB, Azad AK, Schlesinger LS.

J Immunol. 2010 Jul 15;185(2):929-42. doi: 10.4049/jimmunol.1000866. Epub 2010 Jun 16.


A molecular mechanism for ibuprofen-mediated RhoA inhibition in neurons.

Dill J, Patel AR, Yang XL, Bachoo R, Powell CM, Li S.

J Neurosci. 2010 Jan 20;30(3):963-72. doi: 10.1523/JNEUROSCI.5045-09.2010.

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