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Saikosaponin-D enhances radiosensitivity of hepatoma cells under hypoxic conditions by inhibiting hypoxia-inducible factor-1α.

Wang BF, Wang XJ, Kang HF, Bai MH, Guan HT, Wang ZW, Zan Y, Song LQ, Min WL, Lin S, Cheng YA.

Cell Physiol Biochem. 2014;33(1):37-51. doi: 10.1159/000356648. Epub 2014 Jan 2.


Saikosaponin-d increases the radiosensitivity of smmc-7721 hepatocellular carcinoma cells by adjusting the g0/g1 and g2/m checkpoints of the cell cycle.

Wang BF, Dai ZJ, Wang XJ, Bai MH, Lin S, Ma HB, Wang YL, Song LQ, Ma XL, Zan Y, Min WL, Cheng YA.

BMC Complement Altern Med. 2013 Oct 12;13:263. doi: 10.1186/1472-6882-13-263.


Effects of SSd combined with radiation on inhibiting SMMC-7721 hepatoma cell growth.

Wang BF, Lin S, Bai MH, Song LQ, Min WL, Wang M, Yang P, Ma HB, Wang XJ.

Med Sci Monit. 2014 Jul 31;20:1340-4. doi: 10.12659/MSM.891355.


Downregulation of miR-210 expression inhibits proliferation, induces apoptosis and enhances radiosensitivity in hypoxic human hepatoma cells in vitro.

Yang W, Sun T, Cao J, Liu F, Tian Y, Zhu W.

Exp Cell Res. 2012 May 1;318(8):944-54. doi: 10.1016/j.yexcr.2012.02.010. Epub 2012 Feb 24.


Effects of hypoxia-inducible factor-1α silencing on the proliferation of CBRH-7919 hepatoma cells.

Xu LF, Ni JY, Sun HL, Chen YT, Wu YD.

World J Gastroenterol. 2013 Mar 21;19(11):1749-59. doi: 10.3748/wjg.v19.i11.1749.


Hypoxia accelerates cancer invasion of hepatoma cells by upregulating MMP expression in an HIF-1alpha-independent manner.

Miyoshi A, Kitajima Y, Ide T, Ohtaka K, Nagasawa H, Uto Y, Hori H, Miyazaki K.

Int J Oncol. 2006 Dec;29(6):1533-9.


An Akt/hypoxia-inducible factor-1alpha/platelet-derived growth factor-BB autocrine loop mediates hypoxia-induced chemoresistance in liver cancer cells and tumorigenic hepatic progenitor cells.

Lau CK, Yang ZF, Ho DW, Ng MN, Yeoh GC, Poon RT, Fan ST.

Clin Cancer Res. 2009 May 15;15(10):3462-71. doi: 10.1158/1078-0432.CCR-08-2127. Epub 2009 May 15.


Radiosensitization and stromal imaging response correlates for the HIF-1 inhibitor PX-478 given with or without chemotherapy in pancreatic cancer.

Schwartz DL, Bankson JA, Lemos R Jr, Lai SY, Thittai AK, He Y, Hostetter G, Demeure MJ, Von Hoff DD, Powis G.

Mol Cancer Ther. 2010 Jul;9(7):2057-67. doi: 10.1158/1535-7163.MCT-09-0768. Epub 2010 Jun 29.


Effects of knockdown of miR-210 in combination with ionizing radiation on human hepatoma xenograft in nude mice.

Yang W, Wei J, Sun T, Liu F.

Radiat Oncol. 2013 Apr 25;8:102. doi: 10.1186/1748-717X-8-102.


Melittin enhances radiosensitivity of hypoxic head and neck squamous cell carcinoma by suppressing HIF-1α.

Yang X, Zhu H, Ge Y, Liu J, Cai J, Qin Q, Zhan L, Zhang C, Xu L, Liu Z, Yang Y, Yang Y, Ma J, Cheng H, Sun X.

Tumour Biol. 2014 Oct;35(10):10443-8. doi: 10.1007/s13277-014-2218-0. Epub 2014 Jul 23.


Inhibition of hypoxia inducible factor 1alpha causes oxygen-independent cytotoxicity and induces p53 independent apoptosis in glioblastoma cells.

Dai S, Huang ML, Hsu CY, Chao KS.

Int J Radiat Oncol Biol Phys. 2003 Mar 15;55(4):1027-36. Erratum in: Int J Radiat Oncol Biol Phys. 2003 Jun 1;56(2):604.


Expression of hypoxic-inducible factor 1alpha predicts metastasis-free survival after radiation therapy alone in stage IIIB cervical squamous cell carcinoma.

Ishikawa H, Sakurai H, Hasegawa M, Mitsuhashi N, Takahashi M, Masuda N, Nakajima M, Kitamoto Y, Saitoh J, Nakano T.

Int J Radiat Oncol Biol Phys. 2004 Oct 1;60(2):513-21.


Disulfiram deregulates HIF-α subunits and blunts tumor adaptation to hypoxia in hepatoma cells.

Park HJ, Kim MS, Cho K, Yun JH, Choi YJ, Cho CH.

Acta Pharmacol Sin. 2013 Sep;34(9):1208-16. doi: 10.1038/aps.2013.52. Epub 2013 Jul 15.


Effects of YC-1 on hypoxia-inducible factor 1 alpha in hypoxic human bladder transitional carcinoma cell line T24 cells.

Li Y, Zhao X, Tang H, Zhong Z, Zhang L, Xu R, Li S, Wang Y.

Urol Int. 2012;88(1):95-101. doi: 10.1159/000331881. Epub 2011 Oct 25.


[Impact of RNA interference targeting hypoxia-inducible factor-1alpha on chemosensitivity in esophageal squamous cell carcinoma cells under hypoxia].

Wu XA, Sun Y, Fan QX, Wang LX, Wang RL, Zhang L.

Zhonghua Yi Xue Za Zhi. 2007 Oct 9;87(37):2640-4. Chinese.


HIF-1α knockdown by miRNA decreases survivin expression and inhibits A549 cell growth in vitro and in vivo.

Li W, Chen YQ, Shen YB, Shu HM, Wang XJ, Zhao CL, Chen CJ.

Int J Mol Med. 2013 Aug;32(2):271-80. doi: 10.3892/ijmm.2013.1405. Epub 2013 Jun 4.

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