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Items: 1 to 20 of 228

1.

Enhanced ubiquitin-dependent degradation by Nedd4 protects against α-synuclein accumulation and toxicity in animal models of Parkinson's disease.

Davies SE, Hallett PJ, Moens T, Smith G, Mangano E, Kim HT, Goldberg AL, Liu JL, Isacson O, Tofaris GK.

Neurobiol Dis. 2014 Apr;64:79-87. doi: 10.1016/j.nbd.2013.12.011. Epub 2013 Dec 31.

2.

Ubiquitin ligase Nedd4 promotes alpha-synuclein degradation by the endosomal-lysosomal pathway.

Tofaris GK, Kim HT, Hourez R, Jung JW, Kim KP, Goldberg AL.

Proc Natl Acad Sci U S A. 2011 Oct 11;108(41):17004-9. doi: 10.1073/pnas.1109356108. Epub 2011 Sep 27.

3.

Lys-63-linked ubiquitination by E3 ubiquitin ligase Nedd4-1 facilitates endosomal sequestration of internalized α-synuclein.

Sugeno N, Hasegawa T, Tanaka N, Fukuda M, Wakabayashi K, Oshima R, Konno M, Miura E, Kikuchi A, Baba T, Anan T, Nakao M, Geisler S, Aoki M, Takeda A.

J Biol Chem. 2014 Jun 27;289(26):18137-51. doi: 10.1074/jbc.M113.529461. Epub 2014 May 15.

4.

Heat shock protein 70 reduces α-synuclein-induced predegenerative neuronal dystrophy in the α-synuclein viral gene transfer rat model of Parkinson's disease.

Moloney TC, Hyland R, O'Toole D, Paucard A, Kirik D, O'Doherty A, Gorman AM, Dowd E.

CNS Neurosci Ther. 2014 Jan;20(1):50-8. doi: 10.1111/cns.12200. Epub 2013 Nov 27.

PMID:
24279716
5.

Septin 4, the drosophila ortholog of human CDCrel-1, accumulates in parkin mutant brains and is functionally related to the Nedd4 E3 ubiquitin ligase.

Muñoz-Soriano V, Nieto-Arellano R, Paricio N.

J Mol Neurosci. 2012 Sep;48(1):136-43. doi: 10.1007/s12031-012-9788-3. Epub 2012 May 6.

PMID:
22562816
6.

Aldehyde dehydrogenase 1 defines and protects a nigrostriatal dopaminergic neuron subpopulation.

Liu G, Yu J, Ding J, Xie C, Sun L, Rudenko I, Zheng W, Sastry N, Luo J, Rudow G, Troncoso JC, Cai H.

J Clin Invest. 2014 Jul;124(7):3032-46. doi: 10.1172/JCI72176. Epub 2014 May 27.

7.

Rab1A over-expression prevents Golgi apparatus fragmentation and partially corrects motor deficits in an alpha-synuclein based rat model of Parkinson's disease.

Coune PG, Bensadoun JC, Aebischer P, Schneider BL.

J Parkinsons Dis. 2011;1(4):373-87. doi: 10.3233/JPD-2011-11058.

PMID:
23939344
8.

shRNA targeting α-synuclein prevents neurodegeneration in a Parkinson's disease model.

Zharikov AD, Cannon JR, Tapias V, Bai Q, Horowitz MP, Shah V, El Ayadi A, Hastings TG, Greenamyre JT, Burton EA.

J Clin Invest. 2015 Jul 1;125(7):2721-35. doi: 10.1172/JCI64502. Epub 2015 Jun 15.

9.

α-Synuclein-induced dopaminergic neurodegeneration in a rat model of Parkinson's disease occurs independent of ATP13A2 (PARK9).

Daniel G, Musso A, Tsika E, Fiser A, Glauser L, Pletnikova O, Schneider BL, Moore DJ.

Neurobiol Dis. 2015 Jan;73:229-43. doi: 10.1016/j.nbd.2014.10.007. Epub 2014 Oct 18.

PMID:
25461191
10.
11.

Direct detection of alpha synuclein oligomers in vivo.

Dimant H, Kalia SK, Kalia LV, Zhu LN, Kibuuka L, Ebrahimi-Fakhari D, McFarland NR, Fan Z, Hyman BT, McLean PJ.

Acta Neuropathol Commun. 2013 May 9;1:6. doi: 10.1186/2051-5960-1-6.

12.

Nigral overexpression of alpha-synuclein in the absence of parkin enhances alpha-synuclein phosphorylation but does not modulate dopaminergic neurodegeneration.

Van Rompuy AS, Oliveras-Salvá M, Van der Perren A, Corti O, Van den Haute C, Baekelandt V.

Mol Neurodegener. 2015 Jun 23;10:23. doi: 10.1186/s13024-015-0017-8.

13.

Bacterial artificial chromosome transgenic mice expressing a truncated mutant parkin exhibit age-dependent hypokinetic motor deficits, dopaminergic neuron degeneration, and accumulation of proteinase K-resistant alpha-synuclein.

Lu XH, Fleming SM, Meurers B, Ackerson LC, Mortazavi F, Lo V, Hernandez D, Sulzer D, Jackson GR, Maidment NT, Chesselet MF, Yang XW.

J Neurosci. 2009 Feb 18;29(7):1962-76. doi: 10.1523/JNEUROSCI.5351-08.2009.

14.

Alpha-synuclein expression in the substantia nigra of MPTP-lesioned non-human primates.

Purisai MG, McCormack AL, Langston WJ, Johnston LC, Di Monte DA.

Neurobiol Dis. 2005 Dec;20(3):898-906. Epub 2005 Jul 11.

PMID:
16006134
15.

Chronic administration of cholesterol oximes in mice increases transcription of cytoprotective genes and improves transcriptome alterations induced by alpha-synuclein overexpression in nigrostriatal dopaminergic neurons.

Richter F, Gao F, Medvedeva V, Lee P, Bove N, Fleming SM, Michaud M, Lemesre V, Patassini S, De La Rosa K, Mulligan CK, Sioshansi PC, Zhu C, Coppola G, Bordet T, Pruss RM, Chesselet MF.

Neurobiol Dis. 2014 Sep;69:263-75. doi: 10.1016/j.nbd.2014.05.012. Epub 2014 May 18.

16.

The role of ubiquitin linkages on alpha-synuclein induced-toxicity in a Drosophila model of Parkinson's disease.

Lee FK, Wong AK, Lee YW, Wan OW, Chan HY, Chung KK.

J Neurochem. 2009 Jul;110(1):208-19. doi: 10.1111/j.1471-4159.2009.06124.x. Epub 2009 Apr 27.

17.

Conditional expression of Parkinson's disease-related mutant α-synuclein in the midbrain dopaminergic neurons causes progressive neurodegeneration and degradation of transcription factor nuclear receptor related 1.

Lin X, Parisiadou L, Sgobio C, Liu G, Yu J, Sun L, Shim H, Gu XL, Luo J, Long CX, Ding J, Mateo Y, Sullivan PH, Wu LG, Goldstein DS, Lovinger D, Cai H.

J Neurosci. 2012 Jul 4;32(27):9248-64. doi: 10.1523/JNEUROSCI.1731-12.2012.

18.
19.

Comparison between α-synuclein wild-type and A53T mutation in a progressive Parkinson's disease model.

Lu J, Sun F, Ma H, Qing H, Deng Y.

Biochem Biophys Res Commun. 2015 Sep 4;464(4):988-93. doi: 10.1016/j.bbrc.2015.07.007. Epub 2015 Jul 17.

PMID:
26192120
20.

Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons.

Tardiff DF, Jui NT, Khurana V, Tambe MA, Thompson ML, Chung CY, Kamadurai HB, Kim HT, Lancaster AK, Caldwell KA, Caldwell GA, Rochet JC, Buchwald SL, Lindquist S.

Science. 2013 Nov 22;342(6161):979-83. doi: 10.1126/science.1245321. Epub 2013 Oct 24.

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